Results 161 to 170 of about 774,459 (219)

Enhancing cancer vaccine efficacy via electrostatic engineering of an FcγR-targeted protein. [PDF]

Front Immunol
Wu CC, Chen CL, Chiang CY, Tu LL, Liu SJ, Leng CH, Chen HW.   +6 more
europepmc   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Immunomodulation by glycosylation: bridging glycobiology to adaptive immunity and therapeutic innovation. [PDF]

Front Immunol
Ding S, Wang H, Han Z, Hong S.
europepmc   +1 more source

Different Immune Cells Modified With Chimeric Antigen Receptors Are Being Applied to Ovarian Cancer: Which Is the Most Effective? [PDF]

Cancer Med
Wang L, Cao Y, Ren Y, Zhang Y, Wang L.
europepmc   +1 more source

A clinical-grade automated platform for the manufacturing of CAR-γδ T cells for immunotherapy. [PDF]

Front Immunol
Kuska J, Kostyra J, Pinot L, Egorov E, Jelveh N, Martinez Carrera LA, Zhang C, Khorkova S, Assenmacher M, Orentas R, Mueller S, Hidalgo JV.   +11 more
europepmc   +1 more source

B Cell Subsets and Atherosclerosis: Updates and Emerging Concepts. [PDF]

Immunol Rev
Lems S, Mazzei MG, Foks AC, McNamara CA.
europepmc   +1 more source

CAR-engineering of innate and innate-like immune cells: a new horizon in adoptive cell therapy for solid tumors. [PDF]

J Immunother Cancer
Nardo G, Putti F, Indini A, Del Vecchio M, De Braud F, Di Nicola M, De Santis F.   +6 more
europepmc   +1 more source

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Signal Transduction by the B‐Cell Antigen Receptor

Annals of the New York Academy of Sciences, 1995
The antigen receptor of B lymphocytes (BCR) plays important roles in recognition of foreign antigens and self-components to allow the immune system to make appropriate antibody responses. The BCR is a complex between membrane immunoglobulin and the Ig-alpha and Ig-beta heterodimer.
ANTHONY L. DEFRANCO, JAMES D. RICHARDS, JONATHAN H. BLUM, TRACY L. STEVENS, DEBBIE A. LAW, VIVIEN W.‐F. CHAN, SANDIP K. DATTA, SHAUN P. FOY, SHARON L. HOURIHANE, MICHAEL R. GOLD, LINDA MATSUUCHI   +10 more
openaire   +2 more sources