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B cell antigen receptor signaling 101
Molecular Immunology, 2004All cells continually survey their environment and make decisions based on cues encountered. This requires specific receptors that detect such cues, then transduce signals that initiate the appropriate responses. B lymphocytes provide an archetypal model for such 'adaptive' cellular responses, where signals transmitted by the B cell Ag-receptor (BCR ...
Joseph M, Dal Porto +5 more
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Structure and Function of the B Cell Antigen Receptor
Annual Review of Cell Biology, 1993INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 377 STRUCTURE OF THE B CELL ANTIGEN RECEPTOR . . . . . . . . . . . . . . . . . 378 SIGNAL TRANSDUCTION FUNCTION OF THE ANTIGEN RECEPTOR . . . . . 382 TARGETS OF ANTIGEN RECEPTOR-STIMULATED TYROSINE PHOSPHORYLATION . . . . . . . . . . . . . . . . . . . . . .
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Journal of Allergy and Clinical Immunology, 1999
Functional differentiation of B lymphocytes can be regulated at different levels. Such B-cell responses, to a large extent, are under the control of T cells and the release of soluble factors from these cells. Crosslinking of B-cell antigen receptors also can direct B-cell differentiation, although the mechanisms are not well defined and the effects on
A, Oshiba, E W, Gelfand
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Functional differentiation of B lymphocytes can be regulated at different levels. Such B-cell responses, to a large extent, are under the control of T cells and the release of soluble factors from these cells. Crosslinking of B-cell antigen receptors also can direct B-cell differentiation, although the mechanisms are not well defined and the effects on
A, Oshiba, E W, Gelfand
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Regulation of B-cell fate by antigen-receptor signals
Nature Reviews Immunology, 2002Recent evidence indicates that B cells are instructed continuously by B-cell receptor (BCR) signals to make crucial cell-fate decisions at several checkpoints during their development. Targeted disruption of BCR signalling components leads to distinct blocks in B-cell maturation, which indicates that key kinases and adaptors fine-tune BCR signalling to
Hiroaki, Niiro, Edward A, Clark
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2010
1 Structure and Synthesis of the BCR 2 BCR Signaling 3 BCR Antigen Uptake Function 4 Functions of the BCR in B-Cell Maturation and Activation 5 Conclusion Keywords: B-cell antigen receptor (BCR); BCR signaling; B lymphocytes and making antibodies; pre-BCR and B-cell development; protein tyrosine kinase activation by BCR;
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1 Structure and Synthesis of the BCR 2 BCR Signaling 3 BCR Antigen Uptake Function 4 Functions of the BCR in B-Cell Maturation and Activation 5 Conclusion Keywords: B-cell antigen receptor (BCR); BCR signaling; B lymphocytes and making antibodies; pre-BCR and B-cell development; protein tyrosine kinase activation by BCR;
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B-cell development and antigen receptor signalling
Biochemical Society Transactions, 2002B-cell development and function requires the products of the Vav family of genes. Vav proteins act as key components of the antigen receptor signal transduction machinery by integration of signals that control the cell cycle, differentiation and apoptosis.
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Transmembrane signalling by the B-cell antigen receptor
Current Opinion in Immunology, 1994Crosslinking the B-cell antigen receptor is sufficient to generate intracellular signals. Recent work has shown that this signalling capability can be ascribed to the presence of the alpha and beta sheath proteins within the antigen receptor that couple it to signal transduction pathways.
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Molecular Mechanisms of B Cell Antigen Receptor Trafficking
Annals of the New York Academy of Sciences, 2003Abstract: B lymphocytes are among the most efficient cells of the immune system in capturing, processing, and presenting MHC class II restricted peptides to T cells. Antigen capture is essentially restricted by the specificity of the clonotypic antigen receptor expressed on each B lymphocyte.
Marcus R, Clark +3 more
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Identification of Components of the B Cell Antigen Receptor Complex
1991Immunoglobulins (Ig) are well-known as antibody molecules which are present in the serum of all vertebrate species. The mouse has five classes of Ig (IgM, IgD, IgG, IgA and IgE) and most of these antibody classes have different effector function during an immune response.1 Heavy chains of each Ig class exist also in a membrane-bound form23 which is ...
M, Reth +3 more
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Malignant B Cells and Antigenic Receptor: Necessity or Habit?
Leukemia & Lymphoma, 2002B-cell malignancies account for the majority of lymphoid tissue neoplasia. Similar to normal B cells, malignant B cells in most Hodgkin's and non-Hodgkin's types of lymphomas express B-cell receptor (BCR) on their membrane. Since neoplastic B cells retain the capacity to respond to microenvironmental signals, and in many respects still behave as normal
Bocoljub, Ciric, Larry R, Pease
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