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The B-cell antigen receptor of the five immunoglobulin classes
Nature, 1991Several proteins associate with surface IgM to form the antigen receptor. We show that just two, the alpha and beta associated chains, are sufficient to reconstitute an IgM surface receptor in fibroblasts. Contrary to expectation, a common alpha chain associates with all five immunoglobulin classes. We propose that B-cell antigen receptors consist of a
A R, Venkitaraman +3 more
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Is expression of the b-cell antigen receptor repertoire chaotic?
Research in Immunology, 1992terization of uncommited B cell precursors from fetal liver at 12 days of gestation. EMBO J., 11, 593-601. Cumano, A., Paige, C.J., Iscove, N.N. & Brady, G. (1982), Bipotential precursors of B cells and macrophages identified in murine fetal liver at day 12 of gestation. Nature (Lond.), 356, 612-615. Kalled, S.L. & Broder, P.H.
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Molecular mechanisms in B cell antigen receptor signaling
Current Opinion in Immunology, 1997Recent gene-targeting experiments have highlighted the importance of the intracellular protein tyrosine kinases Lyn, Syk, and Btk in BCR signal transduction and B cell development. In addition, the interactions of these kinases and their regulatory mechanisms have been reported.
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Signal transduction from the B cell antigen-receptor
Current Opinion in Immunology, 1999Ligation of the B cell antigen-receptor triggers an intricate maze of intercalated biochemical events that ultimately affect B cell biological responses. Recent advances have helped to connect many loose ends by identifying key adaptor proteins, such as BLNK/SLP-65, defining crucial roles for phosphatidylinositol-3-kinase and mapping pathways ...
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GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING
Annual Review of Immunology, 1999▪ Abstract In B lymphocytes, a signaling complex that contributes to cell fate decisions is the B cell antigen receptor (BCR). Data from knockout experiments in cell lines and mice have revealed distinct functions for the intracellular protein tyrosine kinases (Lyn, Syk, Btk) in BCR signaling and B cell development.
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Signalling Function of the B‐Cell Antigen Receptors
Immunological Reviews, 1993K M, Kim, G, Alber, P, Weiser, M, Reth
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-Vornhagen +2 more
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