Results 71 to 80 of about 1,004,480 (189)

Immunization and Aging: a Learning Process in the Immune Network

, 1998
The immune system can be thought as a complex network of different interacting elements. A cellular automaton, defined in shape-space, was recently shown to exhibit self-regulation and complex behavior and is, therefore, a good candidate to model the ...
A. Coutinho, A. S. Perelson, A. T. Bernardes, Américo T. Bernardes, D. Holmberg, D. Stauffer, N. Jan, N. K. Jerne, R. J. De Boer, R. M. Zorzenon dos Santos, R. M. Zorzenon dos Santos, Rita Maria Zorzenon dos Santos, W. M. Lahmann   +12 more
core   +1 more source

Human Tregs Made Antigen Specific by Gene Modification: The Power to Treat Autoimmunity and Antidrug Antibodies with Precision

Frontiers in Immunology, 2017
Human regulatory CD4+ T cells (Tregs) are potent immunosuppressive lymphocytes responsible for immune tolerance and homeostasis. Since the seminal reports identifying Tregs, vast research has been channeled into understanding their genesis, signature ...
Patrick R. Adair, Yong Chan Kim, Ai-Hong Zhang, Jeongheon Yoon, David W. Scott   +4 more
doaj   +1 more source

Multiple regulatory mechanisms control B-1 B cell activation

Frontiers in Immunology, 2012
B-1 cells constitute a unique subset of B cells identified in several species including mice and humans. B-1 cells are further subdivided into B-1a and B-1b subsets as the former but not the later express CD5.
Vishal eSindhava, Subbarao eBondada
doaj   +1 more source

Production of Living Nanoparticles for Blood Cancer Therapy [PDF]

, 2018
Current cancer therapies leave much to be desired because they are very harmful to the patient and cause a significant decrease in quality of life. Chimeric Antigen Receptors (CAR) are a promising novel approach for treating specific types of leukemia ...
Mitchell, Peter, Pierotti, Michael, Piro, Matthew   +2 more
core   +1 more source

Regulation of B cell fate by chronic activity of the IgE B cell receptor. [PDF]

, 2016
IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR).
Allen, Christopher DC, Chen, Xiangjun, Liu, Wanli, Robinson, Marcus J, Smith, Geoffrey A, Taunton, Jack, Yang, Zhiyong   +6 more
core   +1 more source

Autocrine/paracrine lysophosphatidylserine signaling suppresses B cell aggregation and tertiary lymphoid structure formation

iScience
Summary: Accumulating evidence suggests that Gα13 signaling by G protein-coupled receptors negatively regulate B cell function. We report here that lysophosphatidylserine (LysoPS), an emerging immunoregulatory lysophospholipid, is produced upon B cell ...
Akiharu Uwamizu, Yuji Shinjo, Jumpei Omi, Manae Tatstumi, Kuniyuki Kano, Kumiko Makide, Hajime Kitamura, Michiyo Okudaira, Keita Satoh, Fumiya Fukami, Tasuku Kawano, Tomomitsu Miyasaka, Tomoko Takahashi, Osamu Nakajima, Tomohiko Ohwada, Asuka Inoue, Junken Aoki   +16 more
doaj   +1 more source

Selective inhibitors of phosphoinositide 3-kinase delta: Modulators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignancies

Frontiers in Immunology, 2012
The delta isoform of the p110 catalytic subunit (p110δ) of phosphoinositide 3-kinase is expressed primarily in hematopoietic cells and plays an essential role in B-cell development and function.
Michael R Gold, Kamal D. Puri
doaj   +1 more source

Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease [PDF]

, 1996
To date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic ...
Heufelder, Armin E., Scriba, Peter C., Wenzel, Björn E.   +2 more
core   +1 more source

Tuning B cell responsiveness by antigen receptor isotype

Oncotarget, 2015
The expression of functional B cell antigen receptors (BCRs) is essential for development, survival and activation of B cells. During early developmental stages, immature B cells exclusively express IgM. Cells that pass the immature B cell stage and leave the bone marrow coexpress BCRs of IgM and IgD isotypes, which differ in the usage of the heavy ...
openaire   +2 more sources

Therapeutic effect of CAR-γδT cells targeting at BCMA in multiple myeloma [PDF]

Jichu yixue yu linchuang
Objective To construct chimeric antigen receptors modified γδT cells targeting at BCMA (BCMA CAR-γδT) and to evaluate its efficacy of anti-multiple myeloma in vitro.
LI Yinghui, XU Yi, ZHANG Jianmin, CHEN Hui, HE Wei
doaj   +1 more source