Results 51 to 60 of about 21,215 (175)

Bradykinin Receptors in Metabolic Disorders: A Comprehensive Review

Drugs and Drug Candidates
The kallikrein–kinin system and its B1 and B2 receptors are key regulators in metabolic disorders such as obesity, diabetes, and insulin resistance. Obesity, a chronic and multifactorial condition often associated with comorbidities like type 2 diabetes ...
Jéssica Branquinho, Raquel Leão Neves, Michael Bader, João Bosco Pesquero   +3 more
doaj   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors

Nature Communications, 2018
Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-
Nicholas G. Jendzjowsky, Arijit Roy, Nicole O. Barioni, Margaret M. Kelly, Francis H. Y. Green, Christopher N. Wyatt, Richard L. Pye, Luana Tenorio-Lopes, Richard J. A. Wilson   +8 more
doaj   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice

Frontiers in Aging Neuroscience, 2019
Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system (KKS)
Mariana Toricelli, Mariana Toricelli, Sebastiana Ribeiro Evangelista, Sebastiana Ribeiro Evangelista, Larissa Rolim Oliveira, Tania Araujo Viel, Tania Araujo Viel, Hudson Sousa Buck, Hudson Sousa Buck   +8 more
doaj   +1 more source

The lung is more than an organ of gas exchange: immunocompetency, platelets and implications for drug discovery

British Journal of Pharmacology, EarlyView.
Abstract The lungs have for a long time been recognised as having pharmacological significance as a specific organ to modulate the pharmacokinetics of endogenous substances needed to maintain homeostasis. The lungs are therefore the site of action of certain drugs that act on these homeostatic processes, resulting in systemic effects on the ...
Simon C. Pitchford
wiley   +1 more source

Evaluation of Antioxidant Activity of Methanolic Extracts and some Fractions of Salvia verticillata L. Using Three Different Methods

Journal of Medicinal Plants, 2007
Background: Bradykinin has effects on histaminic response,vessels seepage,cellular reproduction,causing fever, pain and coughs caused by ACE controllers (3,4,6).
E Souri, H Farsam, S Ardestani, M Zolfagharifar   +3 more
doaj  

Potential association of cluster headache with certain COVID‐19 vaccines: An assessment from the pharmacovigilance databases

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background The main objective of our study was to assess the potential association between coronavirus disease 2019 (COVID‐19) vaccination and cluster headache (CH) using a pharmacovigilance approach. A secondary objective was to determine whether COVID‐19 vaccines predominantly triggered onset or worsening of the disease.
Elise K. Van Obberghen, Laura Parigny, Nouha Ben‐Othman, Elliot Ewig, Milou‐Daniel Drici, Alexandre O. Gérard, Sophie Gautier, Michel Lanteri‐Minet   +7 more
wiley   +1 more source

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

Excess of Aminopeptidase A in the Brain Elevates Blood Pressure via the Angiotensin II Type 1 and Bradykinin B2 Receptors without Dipsogenic Effect

International Journal of Hypertension, 2017
Aminopeptidase A (APA) cleaves angiotensin (Ang) II, kallidin, and other related peptides. In the brain, it activates the renin angiotensin system and causes hypertension.
Takuto Nakamura, Masanobu Yamazato, Akio Ishida, Yusuke Ohya   +3 more
doaj   +1 more source