Results 251 to 260 of about 56,351 (295)
Some of the next articles are maybe not open access.
Cannabinoid Receptor Signaling
2005The cannabinoid receptor family currently includes two types: CB1, characterized in neuronal cells and brain, and CB2, characterized in immune cells and tissues. CB1 and CB2 receptors are members of the superfamily of seven-transmembrane-spanning (7-TM) receptors, having a protein structure defined by an array of seven membrane-spanning helices with ...
openaire +2 more sources
Cannabis and cannabinoid receptors
Fitoterapia, 2000Cannabis and cannabinoids exert many of their biological functions through receptor-mediated mechanisms. Two types of cannabinoid receptors have been identified, namely CB(1) and CB(2), both coupled to a G protein. CB(1) receptors have been detected in the central nervous system (where they are responsible for the characteristic effects of Cannabis ...
E. Nocerino +2 more
openaire +3 more sources
Cannabinoid receptors in atherosclerosis
Current Opinion in Lipidology, 2006Recent findings suggesting that cannabinoid receptors are potential targets for the treatment of atherosclerosis are reviewed.Cannabinoids, such as Delta9-tetrahydrocannabinol, the major psychoactive compound of marijuana, their synthetic analogs and endogenous cannabinoid ligands, produce their biological effects by interacting with specific receptors.
Sabine, Steffens, Francois, Mach
openaire +2 more sources
Cannabinoid pharmacology: implications for additional cannabinoid receptor subtypes
Chemistry and Physics of Lipids, 2002Delta(9)-Tetrahydrocannabinol (delta(9)-THC), the primary psychoactive constituent of marijuana (Cannabis sativa), is known to bind to two cannabinoid receptors: CB(1) receptors, located primarily in the brain, and CB(2) receptors, located primarily in the periphery.
Jenny L, Wiley, Billy R, Martin
openaire +2 more sources
Insights into biased signaling at cannabinoid receptors: synthetic cannabinoid receptor agonists
Biochemical Pharmacology, 2019Cannabinoid receptors type 1 (CB1) and type 2 (CB2) are promising targets for a number of diseases, including obesity, neuropathic pain, and multiple sclerosis, among others. Upon ligand-mediated activation of these receptors, multiple receptor conformations could be stabilized, resulting in a complex pattern of possible intracellular effects. Although
Elise Wouters +3 more
openaire +2 more sources
Canonical Cannabinoid Receptors
This chapter will review the basic pharmacology of the canonical cannabinoid receptors. The endocannabinoid system is a complex signalling network involved in a wide range of physiological processes, including pain modulation, appetite regulation, and synaptic plasticity.Beth, Ehrlich +3 more
openaire +2 more sources
Pharmacology of Cannabinoid Receptors
Annual Review of Pharmacology and Toxicology, 1995Two subtypes of cannabinoid receptors, CB1 and CB2, have been described to date, although future investigations may elucidate other receptors. The actions of cannabimimetic agents via CB1 receptors in brain are mediated by GI/O to inhibit adenylate cyclase and Ca2+ channels. Little is known about signal transduction mechanisms utilized by CB2 receptors.
openaire +2 more sources
Cannabinoid receptors and pain
Progress in Neurobiology, 2001Mammalian tissues contain at least two types of cannabinoid receptor, CB(1) and CB(2), both coupled to G proteins. CB(1) receptors are expressed mainly by neurones of the central and peripheral nervous system whereas CB(2) receptors occur centrally and peripherally in certain non-neuronal tissues, particularly in immune cells.
openaire +2 more sources
C&EN Global Enterprise, 2016
Two research groups have independently elucidated the first crystal structures of the cannabinoid receptor CB1, a cell-membrane protein involved in a host of appetite, pain-sensation, memory, and o...
openaire +1 more source
Two research groups have independently elucidated the first crystal structures of the cannabinoid receptor CB1, a cell-membrane protein involved in a host of appetite, pain-sensation, memory, and o...
openaire +1 more source