Results 81 to 90 of about 33,714 (244)

Partial agonist and biased signalling properties of the synthetic enantiomers J113863/UCB35625 at chemokine receptors CCR2 and CCR5 [PDF]

, 2017
Biased agonism at G protein-coupled receptors constitutes a promising area of research for the identification of new therapeutic molecules. In this study we identified two novel biased ligands for the chemokine receptors CCR2 and CCR5 and characterized ...
Corbisier, Jenny, Gales, Céline, Parmentier, Marc, Huszagh, Alexandre, Springael, Jean-Yves   +4 more
core   +1 more source

CCL5-armed oncolytic virus augments CCR5-engineered NK cell infiltration and antitumor efficiency

Journal for ImmunoTherapy of Cancer, 2020
Background Natural killer (NK) cells have potent antitumor activities. Nevertheless, adoptive transfer therapy of NK cells has gained very limited success in patients with solid tumors as most infused NK cells remain circulating in the peripheral blood ...
Yi Zhang, Feng Li, Yuqiao Sheng, Weizhou Hou, Padma Sampath, Daniel Byrd, Stephen Thorne   +6 more
doaj   +1 more source

CCR5 activation and endocytosis in circulating tumor-derived cells isolated from the blood of breast cancer patients provide information about clinical outcome

Breast Cancer Research, 2022
Background CCR5 is a motility chemokine receptor implicated in tumor progression, whose activation and subsequent endocytosis may identify highly aggressive breast cancer cell subtypes likely to spread into the circulatory system.
Ashvathi Raghavakaimal, Massimo Cristofanilli, Cha-Mei Tang, R. K. Alpaugh, Kirby P. Gardner, Saranya Chumsri, Daniel L. Adams   +6 more
doaj   +1 more source

Single‐Cell Profiling Reveals Distinct Immune Hallmarks in Untreated Primary Colorectal and Liver Metastasis Cancers

Chronic Diseases and Translational Medicine, EarlyView.
Features the major cell type compositions among colon and liver metastasis. (A) The study design for single‐cell data analysis. (B) The annotated major cell types. Each type was labeled with a special color. (C) Dot plot of canonical marker genes for major cell types. (D) Bar plot of the percentage for each cell type in individuals. (E) Bar plot of the
Zhixun Zhao, Haipeng Chen, Xu Guan, Zheng Jiang, Zheng Liu, Ming Yang, Hengchang Liu, Tianli Chen, Shuangmei Zou, Yibo Gao, Xishan Wang   +10 more
wiley   +1 more source

Nanoparticles containing siRNA to silence CD4 and CCR5 reduce expression of these receptors and inhibit HIV-1 infection in human female reproductive tract tissue explants

Infectious Disease Reports, 2011
Human Immunodeficiency Virus-type 1 (HIV- 1) binds to CD4 and CCR5 receptors on target cells in the human female reproductive tract. We sought to determine whether reducing levels of messenger RNA (mRNA) transcripts that encode these receptors in female ...
Susan K. Eszterhas, Nicole O. Ilonzo, Jennifer E. Crozier, Stela Celaj, Alexandra L. Howell   +4 more
doaj   +1 more source

Novel Noninvasive Broad‐Spectrum Infrared Treatment of Ulcerative Colitis by Modulating T‐Cell Relocation

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A novel graphene‐based broad‐spectrum infrared (BSIR) device is developed for the noninvasive treatment of ulcerative colitis (UC). BSIR irradiation effectively alleviates colonic inflammation and accelerates mucosal recovery by inducing the systemic relocation of T lymphocytes to the spleen.
Siyu Chen, Jiangtao Zhao, Bohan Jia, Zhigang Ren, Ranran Sun, Liwen Liu, Ding Zhang, Yanqiu Fu, Jia Yu, Shen Shen, Fujun Miao, Zaimei Huang, Ruixia Guo, Peng Zhang, Zujiang Yu, Guosheng Shao   +15 more
wiley   +1 more source

Sequence evolution of the CCR5 chemokine receptor gene in primates [PDF]

Molecular Biology and Evolution, 1999
The chemokine receptor CCR5 can serve as a coreceptor for M-tropic HIV-1 infection and both M-tropic and T-tropic SIV infection. We sequenced the entire CCR5 gene from 10 nonhuman primates: Pongo pygmaeus, Hylobates leucogenys, Trachypithecus francoisi, Trachypithecus phayrei, Pygathrix nemaeus, Rhinopithecus roxellanae, Rhinopithecus bieti ...
Zhang, Y. W., Ryder, O. A., Zhang, Y. P.
openaire   +2 more sources

Analyse par suivi de particule unique à la surface de lymphocytes vivants de l'organisation dynamique des récepteurs CD4 et CCR5 impliqués dans l'infection par le VIH [PDF]

, 2012
L'infection de lymphocytes T CD4+ par le virus de l'immunodéficience humaine (VIH) débute par l'interaction séquentielle de la protéine d'enveloppe du virus gp120 avec le récepteur primaire CD4 puis avec un corécepteur, CCR5 dans la majorité des cas de ...
Mascalchi, Patrice
core  

Non-full-length Water-Soluble CXCR4QTY and CCR5QTY Chemokine Receptors: Implication for Overlooked Truncated but Functional Membrane Receptors

iScience, 2020
Summary: It was posited that functionalities of GPCRs require full-length sequences that are negated by residue deletions. Here we report that significantly truncated nfCCR5QTY and nfCXCR4QTY still bind native ligands.
Rui Qing, Fei Tao, Pranam Chatterjee, Gaojie Yang, Qiuyi Han, Haeyoon Chung, Jun Ni, Bernhard P. Suter, Jan Kubicek, Barbara Maertens, Thomas Schubert, Camron Blackburn, Shuguang Zhang   +12 more
doaj   +1 more source

CCR5 and CXCR3 are dispensable for liver infiltration, but CCR5 protects against virus-induced T-cell-mediated hepatic steatosis [PDF]

, 2007
Udgivelsesdato: 2007-SepCCR5 and CXCR3 are important molecules in regulating the migration of activated lymphocytes. Thus, the majority of tissue-infiltrating T cells found in the context of autoimmune conditions and viral infections express CCR5 and ...
Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Orskov, C, Holst, P J, Qvortrup, K   +4 more
core   +1 more source