Results 141 to 150 of about 2,880,433 (308)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Noncanonical sustained actions of propofol reverse surgery-induced microglial activation and cognitive impairment in aged mice. [PDF]

PNAS Nexus
Nagarajan R, Lyu J, Kambali M, Wang M, Pearce RA, Rudolph U.   +5 more
europepmc   +1 more source

Tomato Ve disease resistance genes encode cell surface-like receptors

Proceedings of the National Academy of Sciences of the United States of America, 2001
L. Kawchuk, J. Hachey, D. Lynch, F. Kulcsar, Gijs van Rooijen, D. Waterer, A. Robertson, E. Kokko, R. Byers, R. Howard, R. Fischer, D. Prüfer   +11 more
semanticscholar   +1 more source

Osmotic pressure‐induced calcium response states

FEBS Open Bio, EarlyView.
Acute hypotonic stress triggers distinct calcium response patterns in HEK293T cells. These signals originate from the endoplasmic reticulum via RyR2 and propagate to neighboring cells through gap junctions. This result highlights a novel calcium‐dependent mechanism underlying the intracellular and intercellular response to osmotic pressure.
Zidan Gao, Keiji Naruse, Masatoshi Morimatsu   +2 more
wiley   +1 more source

Virion motility of sialoglycan-cleaving respiratory viruses. [PDF]

Npj Viruses
Liu M, de Vries E, de Haan CAM.
europepmc   +1 more source

Three classes of cell surface receptors for alphaherpesvirus entry.

Virology, 2000
P. Spear, R. Eisenberg, G. Cohen
semanticscholar   +1 more source

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

FEBS Open Bio, EarlyView.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley   +1 more source

Insights into the Landscape of Alphavirus Receptor and Antibody Interactions. [PDF]

Viruses
Poudyal S, Bandyopadhyay A, Kuhn RJ.
europepmc   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

NK Cells: A Powerful Squad Versus SARS-CoV-2. [PDF]

Int J Mol Sci
Alvarado-Hernández DL, Noyola MV, Martínez-Rider R, Bernal-Silva S, Comas-Garcia A.   +4 more
europepmc   +1 more source