Results 161 to 170 of about 2,510,699 (306)

Soluble forms of herpes simplex virus glycoprotein D bind to a limited number of cell surface receptors and inhibit virus entry into cells

Journal of Virology, 1990
David A. Johnson, Rae Lyn Burke, T. J. Gregory   +2 more
semanticscholar   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Optimization of Immune Checkpoint Blockade via a Multiscale Model System. [PDF]

Comput Syst Oncol
Talkington AM, Kearsley AJ.
europepmc   +1 more source

Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors.

Proceedings of the National Academy of Sciences of the United States of America, 1989
T. Fleming, T. Matsui, C. Molloy, K. Robbins, S. Aaronson   +4 more
semanticscholar   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Albumin Nanoparticles as Multifunctional Carriers for Advanced Therapeutics. [PDF]

Pharmaceutics
Konopska B, Sokołowski J, Woźniak A, Kondracki M, Federowicz J, Grodzki W, Bronowicka-Szydełko A, Madziarska K.   +7 more
europepmc   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Improving Proteostasis of Trafficking-Deficient GABA_A Receptor Variants by Activating IRE1. [PDF]

ACS Chem Neurosci
Fu X, Wang YJ, Lee K, Ahn LY, Chen X, Harvey BT, Wang M, Seibert H, Zhang PP, Guerrero A, Schaffer AE, Richards CI, Wiseman RL, Kelly JW, Mu TW.   +14 more
europepmc   +1 more source

Soluble forms of tumor necrosis factor receptors (TNF‐Rs). The cDNA for the type I TNF‐R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor.

EMBO Journal, 1990
Y. Nophar, O. Kemper, C. Brakebusch, H. Engelmann, Raya Zwang, D. Aderka, H. Holtmann, D. Wallach   +7 more
semanticscholar   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source