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Emerging Applications of Nanotechnology for Controlling Cell-Surface Receptor Clustering.
Angewandte Chemie, 2019The spatial organization of cell-surface receptors plays an important role in defining cell fate. Recently, the development of strategies for the direct regulation of receptor clustering using nanomaterials has aroused enormous interest.
Kaixiang Zhang +3 more
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Cytokine receptor activation at the cell surface
Current Opinion in Structural Biology, 2012Cytokines are well recognized for the pleiotropic nature of their signaling and biological activities on many cell types and their role in health and disease. Recent years have seen a steady stream of new cytokine receptor crystal structures including those that are activated by GM-CSF, type I interferon, and a variety of interleukins.
Sophie E. Broughton +4 more
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Cell surface receptors in lysophospholipid signaling [PDF]
Seminars in Cell & Developmental Biology, 2004 The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), regulate various signaling pathways within cells by binding to multiple G protein-coupled receptors. Receptor-mediated LPA and S1P signaling induces diverse cellular responses including proliferation, adhesion, migration, morphogenesis, differentiation and survival ...
Jerold Chun, Brigitte Anliker
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A model of cell surface receptor aggregation
Journal of Mathematical Biology, 2017In this paper we construct and analyze a model of cell receptor aggregation. Experiments have shown that receptors in an aggregated state have greatly reduced mobility. We model the effects of this reduced mobility with a density dependent diffusion and study the impact of density dependent diffusion on aggregate formation in a one-dimensional domain ...
D. Iron, J. Rumsey
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Cell surface receptors for picornaviruses
BioEssays, 1986AbstractPicornaviruses can be divided into at least six receptor families based on results of competition binding and receptor antibody studies. It has been proposed that a canyon present within the virion capsid harbors the viral attachment site for this group of viruses. Cell surface proteins involved in viral attachment have been identified for both
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GRP78: A Multifunctional Receptor on the Cell Surface
Antioxidants & Redox Signaling, 2009The 78 kDa glucose-regulated protein (GRP78) is an endoplasmic reticulum chaperone, whose function is generally thought to be restricted to controlling the structural maturation of nascent glycoproteins. However, GRP78 also is expressed on the cell surface where it functions as a receptor for a wide variety of ligands, behaving as an autoantigen for ...
Maria Angelica Selim +3 more
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Surfaces for Study of Receptor Dynamics on T Cells
2023Microscopy developments since the turn of the decade have seen an abundance of imaging modalities emerge that are revolutionizing the way we image the immune system. We are now able to image faster and utilize techniques that can image individual receptors, in real time, on live T cells.
James, McColl, David, Klenerman
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Keeping track of cell surface receptor
Trends in Cell Biology, 1992Richard Cherry is at the Department of Chemistry and Biological Chemistry, University of Essex, Wivenhoe Park, Colchester, UK C04 3SQ. Ceil membranes are generally fluid structures in which receptors and other integral membrane proteins are potentially able to diffuse.
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Cell Surface Receptors in Malignant Glioma
Neurosurgery, 2011Despite advances in surgery, radiation, and chemotherapy, malignant gliomas are still highly lethal tumors. Traditional treatments that rely on nonspecific, cytotoxic approaches have a marginal impact on patient survival. However, recent advances in the molecular cancer biology underlying glioma pathogenesis have revealed that abnormalities in common ...
Yan Michael Li, Walter A. Hall
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Cell surface receptors for molecular chaperones
Methods, 2007Heat shock proteins are intracellular molecular chaperones. However, extracellular heat shock proteins have recently been shown to mediate a range of powerful effects in inflammatory cells, neuronal cells and immune cells. These effects are transmitted by a number of cell surface receptors including LRP/CD91, CD40, Toll-like receptors, Scavenger ...
Stuart K. Calderwood +3 more
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