Results 201 to 210 of about 2,926,869 (253)
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Cell‐surface receptors: Puzzles and paradigms
BioEssays, 1986AbstractThe determination of amino acid sequences representing the cell‐surface receptors for transferrin,1 asialoglycoprotein,2 polymeric immunoglobulin (IgA/IgM),3 epidermal growth factor (EGF),4 lowdensity lipoprotein (LDL)5 and insulin6 has produced new paradingms for receptor architecture.
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Cell Surface Receptors and Lymphocyte Migration
Immunological Communications, 1976Lymphocyte subpopulations show a marked specificity in their distribution in various parts of the lymphoid system. It has been suggested that specific localization of lymphocytes depends on the presence of homing" receptors on their cell surface. The present paper summarizes some of the approaches used in the study of cell surface receptors involved in
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1976
The genetic code embodies structural and functional potentialities and in differentiated cells the DNA is analogous to a punch tape that has become programmed, by largely unresolved mechanisms, to delineate the cells’ specialised activity. However, in order for this specific potential to be expressed in tune with the dynamic demands of the environment,
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The genetic code embodies structural and functional potentialities and in differentiated cells the DNA is analogous to a punch tape that has become programmed, by largely unresolved mechanisms, to delineate the cells’ specialised activity. However, in order for this specific potential to be expressed in tune with the dynamic demands of the environment,
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Cell Surface Receptor Labeling
2016Genetic fusion of a reporter such as a fluorescent protein or an enzyme stamps a permanent mark on a protein of interest (POI) that imaging techniques can trace and visualize.
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Aggregation of cell surface receptors by multivalent ligands
Journal of Mathematical Biology, 1982Using a combination of branching processes and kinetic equations a solution is provided to the problem of describing the size of aggregates formed on cell surfaces when multivalent ligands bind and cross-link multivalent receptors. A criterion is given for the onset of gelation in infinite 2-dimensional systems, which may be relevant to the phenomenon ...
Alan S. Perelson, Catherine A. Macken
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Targeting of Drugs to Cell Surface Receptors
Critical Reviews in Biotechnology, 1997The new approach to the treatment of cancer or to immunomodulation is drug targeting. The effort to achieve either an absolute or a relative amplification of the tumoricidal effect of anticancer drugs through increased generation or acquisition of reactive molecules at the tumor site or a reduction of the toxic molecules available to the periphery has ...
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Surface NK receptors and their ligands on tumor cells
Seminars in Immunology, 2006The identification of MHC-class I-specific inhibitory receptors in humans and mice provided a first explanation of why NK cells can kill target cells that have lost or underexpress MHC-class I molecules but spare normal cells. However, the molecular basis of NK-mediated recognition and tumor cell killing revealed a higher degree of complexity.
MORETTA, ALESSANDRO +5 more
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Mesenchymal Stem Cells and Their Cell Surface Receptors
Current Rheumatology Reviews, 2008Daily increasing evidence indicates that stem cells can be found in nearly every tissue. Mesenchymal stem cells (MSCs) are adult stem cells, which reside in the bone marrow and other mesenchymal tissues. MSCs can be expanded to large numbers and can be driven into diverse mesenchymal cell lineages, including chondrocytes. Therefore, MSCs have attracted
Matthias Schieker +2 more
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Cell surface immunoglobulin receptors in B cell development
Seminars in Immunology, 2002Expression of surface immunoglobulin (sIg) related receptors has been conserved in phylogenetically distinct species as a critical checkpoint in B cell development. The sIg receptor comprises extracellular IgM heavy and light chains, with the potential for ligand binding, complexed to the Igalpha/Igbeta heterodimer that is responsible for signal ...
Michael J.H. Ratcliffe +2 more
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The Anchorage of Cell Surface Receptors to the Cytoskeleton [PDF]
, 1981 It is now accepted that the cytoplasm of most cells is not a simple fluid but rather a complex gel, the structure of which is maintained by a variety of intracellular filaments, notably the microfilaments, microtubules and intermediate filaments, collectively referred to as the cytoskeleton.
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