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GRP78: A Multifunctional Receptor on the Cell Surface
Antioxidants & Redox Signaling, 2009The 78 kDa glucose-regulated protein (GRP78) is an endoplasmic reticulum chaperone, whose function is generally thought to be restricted to controlling the structural maturation of nascent glycoproteins. However, GRP78 also is expressed on the cell surface where it functions as a receptor for a wide variety of ligands, behaving as an autoantigen for ...
Maria Angelica Selim +3 more
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Surfaces for Study of Receptor Dynamics on T Cells
2023Microscopy developments since the turn of the decade have seen an abundance of imaging modalities emerge that are revolutionizing the way we image the immune system. We are now able to image faster and utilize techniques that can image individual receptors, in real time, on live T cells.
James, McColl, David, Klenerman
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Keeping track of cell surface receptor
Trends in Cell Biology, 1992Richard Cherry is at the Department of Chemistry and Biological Chemistry, University of Essex, Wivenhoe Park, Colchester, UK C04 3SQ. Ceil membranes are generally fluid structures in which receptors and other integral membrane proteins are potentially able to diffuse.
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Cell surface receptors for molecular chaperones
Methods, 2007Heat shock proteins are intracellular molecular chaperones. However, extracellular heat shock proteins have recently been shown to mediate a range of powerful effects in inflammatory cells, neuronal cells and immune cells. These effects are transmitted by a number of cell surface receptors including LRP/CD91, CD40, Toll-like receptors, Scavenger ...
Stuart K. Calderwood +3 more
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Cell Surface Receptors in Malignant Glioma
Neurosurgery, 2011Despite advances in surgery, radiation, and chemotherapy, malignant gliomas are still highly lethal tumors. Traditional treatments that rely on nonspecific, cytotoxic approaches have a marginal impact on patient survival. However, recent advances in the molecular cancer biology underlying glioma pathogenesis have revealed that abnormalities in common ...
Yan Michael Li, Walter A. Hall
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Cell Surface Receptors and Lymphocyte Migration
Immunological Communications, 1976Lymphocyte subpopulations show a marked specificity in their distribution in various parts of the lymphoid system. It has been suggested that specific localization of lymphocytes depends on the presence of homing" receptors on their cell surface. The present paper summarizes some of the approaches used in the study of cell surface receptors involved in
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1976
The genetic code embodies structural and functional potentialities and in differentiated cells the DNA is analogous to a punch tape that has become programmed, by largely unresolved mechanisms, to delineate the cells’ specialised activity. However, in order for this specific potential to be expressed in tune with the dynamic demands of the environment,
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The genetic code embodies structural and functional potentialities and in differentiated cells the DNA is analogous to a punch tape that has become programmed, by largely unresolved mechanisms, to delineate the cells’ specialised activity. However, in order for this specific potential to be expressed in tune with the dynamic demands of the environment,
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Cell‐surface receptors: Puzzles and paradigms
BioEssays, 1986AbstractThe determination of amino acid sequences representing the cell‐surface receptors for transferrin,1 asialoglycoprotein,2 polymeric immunoglobulin (IgA/IgM),3 epidermal growth factor (EGF),4 lowdensity lipoprotein (LDL)5 and insulin6 has produced new paradingms for receptor architecture.
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Cell Surface Receptor Labeling
2016Genetic fusion of a reporter such as a fluorescent protein or an enzyme stamps a permanent mark on a protein of interest (POI) that imaging techniques can trace and visualize.
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Aggregation of cell surface receptors by multivalent ligands
Journal of Mathematical Biology, 1982Using a combination of branching processes and kinetic equations a solution is provided to the problem of describing the size of aggregates formed on cell surfaces when multivalent ligands bind and cross-link multivalent receptors. A criterion is given for the onset of gelation in infinite 2-dimensional systems, which may be relevant to the phenomenon ...
Alan S. Perelson, Catherine A. Macken
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