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GRP78: A Multifunctional Receptor on the Cell Surface
Antioxidants & Redox Signaling, 2009The 78 kDa glucose-regulated protein (GRP78) is an endoplasmic reticulum chaperone, whose function is generally thought to be restricted to controlling the structural maturation of nascent glycoproteins. However, GRP78 also is expressed on the cell surface where it functions as a receptor for a wide variety of ligands, behaving as an autoantigen for ...
Mario, Gonzalez-Gronow +3 more
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Cell surface receptors for molecular chaperones
Methods, 2007Heat shock proteins are intracellular molecular chaperones. However, extracellular heat shock proteins have recently been shown to mediate a range of powerful effects in inflammatory cells, neuronal cells and immune cells. These effects are transmitted by a number of cell surface receptors including LRP/CD91, CD40, Toll-like receptors, Scavenger ...
Stuart K, Calderwood +3 more
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Keeping track of cell surface receptor
Trends in Cell Biology, 1992Richard Cherry is at the Department of Chemistry and Biological Chemistry, University of Essex, Wivenhoe Park, Colchester, UK C04 3SQ. Ceil membranes are generally fluid structures in which receptors and other integral membrane proteins are potentially able to diffuse.
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A model of cell surface receptor aggregation
Journal of Mathematical Biology, 2017In this paper we construct and analyze a model of cell receptor aggregation. Experiments have shown that receptors in an aggregated state have greatly reduced mobility. We model the effects of this reduced mobility with a density dependent diffusion and study the impact of density dependent diffusion on aggregate formation in a one-dimensional domain ...
D. Iron, J. Rumsey
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Cell Surface Receptors in Malignant Glioma
Neurosurgery, 2011Despite advances in surgery, radiation, and chemotherapy, malignant gliomas are still highly lethal tumors. Traditional treatments that rely on nonspecific, cytotoxic approaches have a marginal impact on patient survival. However, recent advances in the molecular cancer biology underlying glioma pathogenesis have revealed that abnormalities in common ...
Yan Michael, Li, Walter A, Hall
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Targeting of Drugs to Cell Surface Receptors
Critical Reviews in Biotechnology, 1997The new approach to the treatment of cancer or to immunomodulation is drug targeting. The effort to achieve either an absolute or a relative amplification of the tumoricidal effect of anticancer drugs through increased generation or acquisition of reactive molecules at the tumor site or a reduction of the toxic molecules available to the periphery has ...
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1976
The genetic code embodies structural and functional potentialities and in differentiated cells the DNA is analogous to a punch tape that has become programmed, by largely unresolved mechanisms, to delineate the cells’ specialised activity. However, in order for this specific potential to be expressed in tune with the dynamic demands of the environment,
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The genetic code embodies structural and functional potentialities and in differentiated cells the DNA is analogous to a punch tape that has become programmed, by largely unresolved mechanisms, to delineate the cells’ specialised activity. However, in order for this specific potential to be expressed in tune with the dynamic demands of the environment,
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Cell‐surface receptors: Puzzles and paradigms
BioEssays, 1986AbstractThe determination of amino acid sequences representing the cell‐surface receptors for transferrin,1 asialoglycoprotein,2 polymeric immunoglobulin (IgA/IgM),3 epidermal growth factor (EGF),4 lowdensity lipoprotein (LDL)5 and insulin6 has produced new paradingms for receptor architecture.
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Surface NK receptors and their ligands on tumor cells
Seminars in Immunology, 2006The identification of MHC-class I-specific inhibitory receptors in humans and mice provided a first explanation of why NK cells can kill target cells that have lost or underexpress MHC-class I molecules but spare normal cells. However, the molecular basis of NK-mediated recognition and tumor cell killing revealed a higher degree of complexity.
MORETTA, ALESSANDRO +5 more
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Cell Surface Receptors and Lymphocyte Migration
Immunological Communications, 1976Lymphocyte subpopulations show a marked specificity in their distribution in various parts of the lymphoid system. It has been suggested that specific localization of lymphocytes depends on the presence of homing" receptors on their cell surface. The present paper summarizes some of the approaches used in the study of cell surface receptors involved in
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