Results 21 to 30 of about 743,802 (291)
Cancer Cell International, 2022 Background Immunotherapy with immune checkpoint inhibitors (ICI) has revolutionized cancer therapy. However, therapeutic targeting of inhibitory T cell receptors such as PD-1 not only initiates a broad immune response against tumors, but also causes ...
Simon Heumos +7 more
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Topological and Structural Plasticity of the Single Ig Fold and the Double Ig Fold Present in CD19
Biomolecules, 2021 The Ig fold has had a remarkable success in vertebrate evolution, with a presence in over 2% of human genes. The Ig fold is not just the elementary structural domain of antibodies and TCRs, it is also at the heart of a staggering 30% of immunologic cell ...
Philippe Youkharibache
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Division of labor between dendritic cell subsets of the lung [PDF]
, 2008 Dendritic cells (DCs) are a heterogenous population of antigen-presenting cells, of which conventional DCs and plasmacytoid DCs are the main subsets. Like DC subsets in the central lymphoid organs, DC subsets in the lungs exert specific functions that ...
Lambrecht, Bart +2 more
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Cell-surface translational dynamics of nicotinic acetylcholine receptors
Frontiers in Synaptic Neuroscience, 2014 Synapse efficacy heavily relies on the number of neurotransmitter receptors available at a given time. In addition to the equilibrium between the biosynthetic production, exocytic delivery and recycling of receptors on the one hand, and the endocytic ...
Francisco J Barrantes
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GPCR and G proteins: drug efficacy and activation in live cells. [PDF]
, 2009 Many biochemical pathways are driven by G protein-coupled receptors, cell surface proteins that convert the binding of extracellular chemical, sensory, and mechanical stimuli into cellular signals. Their interaction with various ligands triggers receptor
Vilardaga, JP;Bünemann, M;Feinstein, TN;Lambert, N;Nikolaev, VO;Engelhardt, S;Lohse, MJ;Hoffmann, C
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Biomarkers Indicative of Blood-Brain Barrier Disruption in Multiple Sclerosis [PDF]
, 2006 Blood-brain barrier (BBB) disruption is one of the hallmarks of multiple sclerosis (MS). It is incompletely understood whether BBB disruption is the initial MS event leading to MS lesion formation or whether it is merely a consequence of cellular ...
Waubant, Emmanuelle
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The Proteomic Landscape of the Coronary Accessible Heart Cell Surfaceome [PDF]
Cell surface proteins (surfaceome) represent key signalling and interaction molecules for therapeutic targeting, biomarker profiling and cellular phenotyping in physiological and pathological states.
Inocencio, I +3 more
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Anterograde Trafficking of CXCR4 and CCR2 Receptors in a Prostate Cancer Cell Line
Cellular Physiology and Biochemistry, 2013 Background: Most prostate cancer-related deaths result from metastasis. CXCR4 and CCR2 are known to govern cellular processes resulting in cell migration, proliferation and survival.
Kelsie Gillies +3 more
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Molecular recognition of paired receptors in the immune system
Frontiers in Microbiology, 2012 Cell surface receptors are responsible for regulating cellular function on the front line, the cell membrane. Interestingly, accumulating evidence clearly reveals that the members of cell surface receptor families have very similar extracellular ligand ...
Kimiko eKuroki +4 more
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Compartmentalisation of surface receptor signalling in T cells [PDF]
, 2021 The main goal of this thesis is to introduce the topic of compartmentalisation of signalling on the surface of T lymphocytes before and during the T-lymphocyte activation by the contact with an antigen-presenting cell (APC) or a target cell.
Paldusová, Kateřina
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