Results 11 to 20 of about 78,685 (264)

Engineering and Design of Chimeric Antigen Receptors [PDF]

Molecular Therapy: Methods & Clinical Development, 2019
T cells engineered with chimeric antigen receptors (CARs) have emerged as a potent new class of therapeutics for cancer, based on their remarkable potency in blood cancers.
Sonia Guedan, Hugo Calderon, Avery D. Posey, Jr., Marcela V. Maus   +3 more
doaj   +5 more sources

Chimeric antigen receptors that trigger phagocytosis [PDF]

eLife, 2018
Chimeric antigen receptors (CARs) are synthetic receptors that reprogram T cells to kill cancer. The success of CAR-T cell therapies highlights the promise of programmed immunity and suggests that applying CAR strategies to other immune cell lineages may
Meghan A Morrissey, Adam P Williamson, Adriana M Steinbach, Edward W Roberts, Nadja Kern, Mark B Headley, Ronald D Vale   +6 more
doaj   +5 more sources

Chimeric Antigen Receptors for T-Cell Malignancies [PDF]

Frontiers in Oncology, 2019
Development of chimeric antigen receptor (CAR)-modified T cells for the treatment of T-lineage leukemia and lymphoma has encountered several unique challenges. The most widely expressed tumor antigen targets for malignant T cells are often also expressed
Lauren D. Scherer, Lauren D. Scherer, Malcolm K. Brenner, Malcolm K. Brenner, Malcolm K. Brenner, Maksim Mamonkin, Maksim Mamonkin, Maksim Mamonkin, Maksim Mamonkin   +8 more
doaj   +3 more sources

Chimeric switch and inverted cytokine receptors in T cell therapy: reprogramming T cells to overcome immune suppression in the solid tumor microenvironment [PDF]

Frontiers in Immunology
Adoptive T cell therapy has transformed cancer treatment, with chimeric antigen receptor (CAR) T cell therapy demonstrating remarkable clinical success in hematological malignancies.
Riley Rane, Riley Rane, Fengqiao Li, Fengqiao Li, Alexis Williams, Alexis Williams, Avaneesh Jayadev, Avaneesh Jayadev, Nhan L. Tran, Nhan L. Tran, Jeffrey A. Winkles, Jeffrey A. Winkles, Gloria B. Kim, Gloria B. Kim   +13 more
doaj   +2 more sources

Toward high-throughput engineering techniques for improving CAR intracellular signaling domains

Frontiers in Bioengineering and Biotechnology, 2023
Chimeric antigen receptors (CAR) are generated by linking extracellular antigen recognition domains with one or more intracellular signaling domains derived from the T-cell receptor complex or various co-stimulatory receptors.
Savannah E. Butler, Savannah E. Butler, Colin J. Hartman, Colin J. Hartman, Yina H. Huang, Yina H. Huang, Margaret E. Ackerman, Margaret E. Ackerman   +7 more
doaj   +1 more source

Unlocking the potential of Tregs: innovations in CAR technology

Frontiers in Molecular Biosciences, 2023
Regulatory T cells (Tregs) adoptive immunotherapy is emerging as a viable treatment option for both autoimmune and alloimmune diseases. However, numerous challenges remain, including limitations related to cell number, availability of target-specific ...
Christopher J. Requejo Cier, Nicolas Valentini, Caroline Lamarche   +2 more
doaj   +1 more source

Chimeric non-antigen receptors in T cell-based cancer therapy

Journal for ImmunoTherapy of Cancer, 2021
Adoptively transferred T cell-based cancer therapies have shown incredible promise in treatment of various cancers. So far therapeutic strategies using T cells have focused on manipulation of the antigen-recognition machinery itself, such as through ...
Andrew Kent, Eduardo Davila, Jitao Guo
doaj   +1 more source

Therapeutic applications of engineered chimeric antigen receptors-T cell for cancer therapy

Beni-Suef University Journal of Basic and Applied Sciences, 2022
Background Findings of new targeted treatments with adequate safety evaluations are essential for better cancer cures and mortality rates. Immunotherapy holds promise for patients with relapsed disease, with the ability to elicit long-term remissions ...
Amina Hussain
doaj   +1 more source

CAR T Cells: Cancer Cell Surface Receptors Are the Target for Cancer Therapy [PDF]

Advanced Pharmaceutical Bulletin, 2022
Immunotherapy has become a prominent strategy for the treatment of cancer. A method thatimproves the immune system’s ability to attack a tumor (Enhances antigen binding).
Behrouz Shademan, Vahidreza Karamad, Alireza Nourazarian, Cigir Biray Avcı   +3 more
doaj   +1 more source

Engineering Chimeric Antigen Receptors [PDF]

Acta Naturae, 2017
Chimeric antigen receptors (CARs) are recombinant protein molecules that redirect cytotoxic lymphocytes toward malignant and other target cells. The high feasibility of manufacturing CAR-modified lymphocytes for the therapy of cancer has spurred the development and optimization of new CAR T cells directed against a broad range of target antigens.
S V, Kulemzin, V V, Kuznetsova, M, Mamonkin, A V, Taranin, A A, Gorchakov   +4 more
openaire   +2 more sources