Results 171 to 180 of about 30,055 (235)
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Cellular and Molecular Neurobiology, 1995
The cholecystokinin (CCK) and gastrin families of peptides act as hormones and neuropeptides on central and peripheral CCK receptors to mediate secretion and motility in the gastrointestinal (GI) tract in the physiological response to a normal meal. CCK and its receptors are also widely distributed in the central nervous system (CNS) and contribute to
P, Boden, M D, Hall, J, Hughes
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The cholecystokinin (CCK) and gastrin families of peptides act as hormones and neuropeptides on central and peripheral CCK receptors to mediate secretion and motility in the gastrointestinal (GI) tract in the physiological response to a normal meal. CCK and its receptors are also widely distributed in the central nervous system (CNS) and contribute to
P, Boden, M D, Hall, J, Hughes
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Cholecystokinin receptor antagonists
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1984Since 1979 three classes of cholecystokinin receptor antagonists have been described: 1) derivatives of cyclic nucleotides, 2) derivatives of amino acids, and 3) C-terminal fragments or partial sequences of cholecystokinin. These various antagonists share a number of common features, such as their specific, reversible, and competitive actions, but ...
J D, Gardner, R T, Jensen
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Pharmacogenetics, 2003
Cholecystokinin modulates the release of dopamine and dopamine-related behaviours in the mesolimbic pathway, where cholecystokinin and dopamine coexist in dopaminergic neurones. Because cholecystokinin and its receptors (A and B) have a functional interaction with dopaminergic neurotransmission, alterations in them may constitute a predisposition for ...
Jian, Wang +3 more
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Cholecystokinin modulates the release of dopamine and dopamine-related behaviours in the mesolimbic pathway, where cholecystokinin and dopamine coexist in dopaminergic neurones. Because cholecystokinin and its receptors (A and B) have a functional interaction with dopaminergic neurotransmission, alterations in them may constitute a predisposition for ...
Jian, Wang +3 more
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Cholecystokinin and Gastrin Receptors
Physiological Reviews, 2006Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled receptors that have been the subject of intensive research in the last 10 years with corresponding advances in the understanding of their functioning and physiology. In this review, we first describe general properties of the receptors, such as the different signaling ...
Marlène, Dufresne +2 more
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Cholecystokinin 1(A) Receptor Polymorphisms
Current Topics in Medicinal Chemistry, 2007Since the isolation and sequencing of cholecystokinin (CCK), considerable advances have been made in understanding the roles played by this peptide as a hormone and as a neuropeptide. CCK-1(A) and 2(B) receptor (R) cDNAs have been cloned; shortly thereafter, the naturally occurring CCK-1R gene-deficient rat (the Otsuka Long-Evans Tokushima Fatty (OLETF)
Kyoko, Miyasaka +2 more
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Cholecystokinin-octapeptide fragments: Binding to brain cholecystokinin receptors
European Journal of Pharmacology, 1984Structural determinants of cholecystokinin octapeptide (CCK-8) binding to central nervous system receptors have been studied to assess the relative importance of the amino and the carboxyl end of the active peptide sequence, CCK-(26-33). The relative ability to inhibit equilibrium binding of [125I]CCK-33 to guinea pig cortical membranes was determined ...
M. Knight +5 more
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2002
Abstract Cholecystokinin (CCK) is a peptide originally discovered in the gastrointestinal tract (Ivy and Oldberg 1928), but also found in high density in the mammalian CNS (Vanderhaeghen et al . 1975). This peptide, initially characterized as a 33 amino acid sequence, is present in a variety of biologically active molecular forms ...
Florence Noble, Bernard P Roques
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Abstract Cholecystokinin (CCK) is a peptide originally discovered in the gastrointestinal tract (Ivy and Oldberg 1928), but also found in high density in the mammalian CNS (Vanderhaeghen et al . 1975). This peptide, initially characterized as a 33 amino acid sequence, is present in a variety of biologically active molecular forms ...
Florence Noble, Bernard P Roques
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Nonpeptide Cholecystokinin-2 Receptor Agonists
Journal of Medicinal Chemistry, 2001In the course of structural explorations around a series of potent CCK2 receptor antagonists, it was noted that simple N-methylation of the indolic N-H in the parent molecule gave rise to behavior in vivo that was consistent with the compound acting as an agonist.
S B, Kalindjian +7 more
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Dopamine receptor elevation by cholecystokinin
Peptides, 1984High concentrations of cholecystokinin (CCK) in the striatum and limbic areas of the brain suggest that this peptide may influence dopaminergic transmission. Thus, the effect of CCK on dopamine D2 receptors in the striatum and nucleus accumbens of the rat brain both in vitro and in vivo (central and peripheral administration) was studied by determining
A, Dumbrille-Ross, P, Seeman
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