Results 101 to 110 of about 2,364,275 (293)

Cholinergic neurons in the dorsomedial hypothalamus regulate food intake

Molecular Metabolism, 2017
Objective: Central cholinergic neural circuits play a role in the regulation of feeding behavior. The dorsomedial hypothalamus (DMH) is considered the appetite-stimulating center and contains cholinergic neurons.
Jae Hoon Jeong, Dong Kun Lee, Young-Hwan Jo   +2 more
doaj  

Pathophysiological Role of Primary Motor Cortex in Essential Tremor

Movement Disorders, EarlyView.
Abstract Background Essential tremor (ET) is one of the most prevalent movement disorders. However, the complete understanding of ET pathophysiology remains elusive. Objective To explore the pathophysiological role of primary motor cortex (M1) in ET, specifically exploring its neurophysiological changes and their correlation with voluntary motor ...
Daniele Birreci, Luca Angelini, Giulia Paparella, Davide Costa, Antonio Cannavacciuolo, Massimiliano Passaretti, Martina De Riggi, Simone Aloisio, Donato Colella, Andrea Guerra, Matteo Bologna   +10 more
wiley   +1 more source

Distinct Longitudinal Clinical‐Neuroanatomical Trajectories in Parkinson's Disease Clinical Subtypes: Insight toward Precision Medicine

Movement Disorders, EarlyView.
ABSTRACT Background Parkinson's disease (PD) varies widely across individuals in clinical manifestations and course of progression. Identification of distinct biological subtypes could explain this heterogeneity, identify its pathophysiology, and predict disease progression. Objectives Our aim was to compare longitudinal clinical trajectories and brain
Seyed‐Mohammad Fereshtehnejad, Roqaie Moqadam, Houman Azizi, Ronald B. Postuma, Mahsa Dadar, Anthony E. Lang, Connie Marras, Yashar Zeighami   +7 more
wiley   +1 more source

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light

Medicinal Research Reviews, EarlyView.
ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva, Carlo Matera, Silvia Roda, Alessio Colleoni, Marco De Amici, Pau Gorostiza   +5 more
wiley   +1 more source

Acetylcholine in irritable bowel syndrome pathogenesis and the role of cholineblockers

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2011
The aim of review. To demonstrate value of disorders of cholinergic innervation in pathogenesis of irritable bowel syndrome (IBS).Original positions. The important place in regulation of gastro-intestinal tract functions belongs not only to M-, but also ...
Yu. O. Shulpekova
doaj  

Subtle changes in striatal muscarinic M1 and M4 receptor expression in the DYT1 knock-in mouse model of dystonia.

PLoS ONE, 2019
In early-onset generalized torsion dystonia, caused by a GAG deletion in TOR1A (DYT1), enhanced striatal cholinergic activity has been suggested to be critically involved. Previous studies have shown increased acetylcholine levels in the striatum of DYT1
Franziska Richter, Laura Klein, Christin Helmschrodt, Angelika Richter   +3 more
doaj   +1 more source

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

Inflammation in stroke: the role of cholinergic, purinergic and glutamatergic signaling

Therapeutic Advances in Neurological Disorders, 2018
The inflammatory response is a major factor in stroke pathophysiology and contributes to secondary neuronal damage in both acute and chronic stages of the ischemic injury.
Abraham Martín, María Domercq, Carlos Matute   +2 more
doaj   +1 more source

Synthesis and Characterization of Co(II), Cu(II), and Ni(II) Complexes of 2,2′‐Bipyridine‐4,4′‐Dicarboxamide Ligands: Antibacterial Evaluation Against Resistant Bacteria and Enzyme Inhibition

ChemistryOpen, EarlyView.
Two new 2,2′‐bipyridine‐4,4′‐dicarboxamide ligands and their Co(II), Cu(II), and Ni(II) complexes are synthesized and characterized. The L2‐Co complex shows strong antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
Hussein Alchurak, Aseel Almadhoun, İsmail Yılmaz, Raneem Mamoun Ali Nour, Müslüm Kuzu, Hasan Solmaz   +5 more
wiley   +1 more source

Proteolytic stabilization of a spider venom peptide results in an orally active bioinsecticide

Pest Management Science, EarlyView.
Selective editing out of an insect gut protease cleavage site renders a spider‐derived insecticidal peptide active by ingestion by insect pests. Abstract BACKGROUND The toxin peptide U1‐AGTX‐Ta1b from the Hobo spider, Eratigena agrestis (Walckenaer, 1802), was studied to determine its potential to serve as a bioinsecticide.
Breck R. Davis, Alexandra M. Haase, Joseph S. Tourtois, Daniel L. Hulbert, Rachel E. Cornell, Brian T. DeVree, Cadence J. Flohrschutz, Lucille M. Bell, Daniel C. Peck, Trang T. Nguyen, Lin Bao, Robert M. Kennedy, Kyle D. Schneider   +12 more
wiley   +1 more source