Results 131 to 140 of about 141,255 (305)
Frontiers in Behavioral NeuroscienceIn the retrosplenial cortex (RSC), the role of cholinergic modulation via α7 nicotinic receptors and their involvement in memory is unknown. In recent years, the RSC has been shown to deteriorate in the early stages of Alzheimer’s disease (AD). Likewise,
Verónica Pastor +3 more
doaj +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at ...
Fábio Campos +3 more
wiley +1 more source
Biological Functions of Keratinocyte Cholinergic Receptors
Journal of Investigative Dermatology Symposium Proceedings, 1997 Human epidermal keratinocytes possess cholinergic enzymes, which synthesize and degrade acetylcholine, and express both nicotinic and muscarinic classes of cholinergic receptors on their cell surfaces. These receptors bind acetylcholine and initiate cellular response.
openaire +2 more sources
Environmental Toxicology, EarlyView.ABSTRACT Bisphenol A (BPA), a common industrial chemical used in plastics and consumer products, is increasingly detected in aquatic environments, raising serious concerns about its potential ecological impacts. This study evaluated the sublethal and acute toxic effects of BPA on the freshwater planarian Girardia tigrina, a recognized model for ...
Raquel de Jesus Selestrino +2 more
wiley +1 more source
Environmental Toxicology, EarlyView.ABSTRACT This study assessed the ecotoxicological effects of treated sewage on the freshwater planarian Girardia tigrina, integrating biochemical, energetic, and behavioral biomarkers. Planarians were exposed for 48 h to different concentrations of treated sewage (12.5%, 25%, 50%, and 100%) and compared to controls using commercial water and water from
Renata M. P. Freitas +3 more
wiley +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Endocrine‐disrupting chemicals (EDCs), such as 17α‐ethinylestradiol (EE2), have raised concerns about their potential effects on aquatic organisms, particularly during early developmental stages. In this context, the study of behavioral disruption has gained considerable attention, as it may have consequences on individual fitness and ...
Soloperto Sofia +6 more
wiley +1 more source
The contribution of drugs and toxins to understanding of cholinergic function. [PDF]
, 1990 Whittaker, V.
core +1 more source
Zoo Biology, EarlyView.ABSTRACT The emergence of anthelminthic resistance is a well‐documented phenomenon in livestock and companion animals. Given the scarcity of new antiparasitic drugs, the implementation of effective, holistic anthelminthic control strategies is critical to preserving the efficacy of existing treatments.
Stalder Sandro, Hatt Jean‐Michel
wiley +1 more source
Structural insights into the binding mode of the hypnotic drug vornorexant to orexin receptors
Acta Crystallographica Section F, EarlyView.The crystal structure of the human orexin type 2 receptor–vornorexant complex (3.29 Å resolution) and orexin type 1 receptor docking revealed a conserved U‐shaped binding conformation, explaining the high affinity and balanced dual antagonism of this dual orexin receptor antagonist. The structural data validate the rational design that incorporated a 1,
Masashi Mima +4 more
wiley +1 more source
Addiction, EarlyView.Abstract Background and aims Evidence on the causal impact and corresponding risk relationships between dimensions of alcohol consumption and health outcomes continues to evolve, with some contradictory findings across study designs. This review aimed to update current knowledge on causality and risk relationships to inform global and national ...
Sinclair Carr +5 more
wiley +1 more source