Results 261 to 270 of about 141,255 (305)

Receptors in neurodegenerative diseases, muscarinic cholinergic receptors

Pharmaceutica Acta Helvetiae, 2000
Publisher Summary Muscarinic acetylcholine receptors are present in the mammalian central nervous system (CNS) and in the periphery. Their stimulation produces inhibitory responses, such as bradycardia and vascular smooth muscle dilatation, and excitatory responses, such as ganglionic depolarization and smooth muscle contraction. Muscarinic receptors
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Cholinergic muscarinic receptors in rat cochlea

Brain Research, 1988
Specific 3H-1-quinuclidinylbenzilate (3H-1-QNB) binding to rat cochlea homogenates occurs to a homogeneous class of binding sites with Kd = 0.13 +/- 0.01 nM and Bmax = 0.57 +/- 0.07 fmol per cochlea. Binding is stereoselectively inhibited by benzetimide enantiomers.
Y J, van Megen, A B, Klaassen, J F, Rodrigues de Miranda, W, Kuijpers   +3 more
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Muscarinic cholinergic receptors in goldfish retina

Life Sciences, 1979
Abstract Using 3 H-Quinuclinidyl Benzilate ( 3 H-QNB) as a high affinity ligand for quantitative studies of specific binding to muscarinic cholinergic receptors we have demonstrated the presence of such receptors in homogenates of goldfish retina. Only one set of binding sites could be detected with an apparent dissociation constant of 1.9 × 10 −10
J A, Moreno-Yanes, H R, Mahler
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Isopilocarpine Binding to Muscarinic Cholinergic Receptors

Journal of Pharmaceutical Sciences, 1986
Isopilocarpine coexists with pilocarpine in nature, and it is present in varying degrees in commercial pilocarpine preparations. Using muscarinic cholinergic receptors from bovine ciliary muscle tissue, we measured the relative binding affinity of isopilocarpine and pilocarpine. The binding affinity of isopilocarpine was approximately one-tenth that of
M V, Drake, J J, O'Donnell, J R, Polansky   +2 more
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Cholinergic Receptor Isolation

1981
The isolation of specific cholinergic bindin protein (acetylcholine receptor = AChR) has been achieved successfully by numerous research groups (1-4, 7-9, 11, 12). The ideal source for such preparations was the electric organ of several species of Torpedo.
W. H. Hopff, A. A. Hofmann, G. Riggio, P. G. Waser   +3 more
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The nicotinic cholinergic receptor: A theoretical model

Journal of Neuroscience Research, 1996
Based on published affinity-labeling and mutagenesis experiments describing the effect of changes in specific amino acids in molecular biological studies on the nicotinic acetylcholinergic receptor (nAChR), we have identified 12 amino acids which are important in functioning at the nicotinic cholinergic receptor.
M H, Aprison, E, Galvez-Ruano, K B, Lipkowitz   +2 more
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Cholinergic receptors in insects

Trends in Biochemical Sciences, 1979
Abstract It has been suggested that cholinergic receptors in insects are neither nicotinic nor muscarinic but of a mixed nature, and hence differ from ‘classic' vertebrate receptors. However, recent evidence indicates that insects also contain distinct nicotinic and muscarinic binding-sites with properties resembling those of vertebrate receptors. The
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Nicotinic cholinergic receptors in brain synaptosomes

Brain Research, 1979
In order to elucidate pharmacological characteristics of nicotinic receptors in the brain, competitive binding of nicotine analogues or cholinergic agents to brain particles was studied utilizing [3H]nicotine. The binding of [3H]nicotine to brain crude nitochondrial or synaptosomal fraction was progressively inhibited by the addition of increasing ...
K, Yoshida, H, Imura
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Modulation of DNA Synthesis by Muscarinic Cholinergic Receptors

Growth Factors, 2001
Acetylcholine muscarinic receptors are a family of five G-protein-coupled receptors widely distributed in the central nervous system and in peripheral organs. Activation of certain subtypes of muscarinic receptors (M1, M3, M5) has been found to modulate DNA synthesis in a number of cell types.
COSTA, Lucio Guido, M. Guizetti, J. Oberdoester, P. Yagle, Paola Costa Mallen, TITA, Beatrice, Federica Bordi, VITALONE, Annabella, PALMERY, Maura, VALERI, Pacifico   +9 more
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[Cholinergic receptors and anesthesia].

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1992
Postsynaptic chemically controlled ion channels are a possible location for the action of anaesthetics. The nicotinic acetylcholine receptor (AcChoR) is a member of a superfamily of chemically controlled ion channels, which have a large number of structural similarities in common.
P H, Tonner, K W, Miller
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