Results 81 to 90 of about 2,364,275 (293)

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders

Exploration, EarlyView.
Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen   +4 more
wiley   +1 more source

Olfactory Bulb Muscarinic Acetylcholine Type 1 Receptors Are Required for Acquisition of Olfactory Fear Learning

Frontiers in Behavioral Neuroscience, 2019
The olfactory bulb (OB) receives significant cholinergic innervation and widely expresses cholinergic receptors. While acetylcholine (ACh) is essential for olfactory learning, the exact mechanisms by which ACh modulates olfactory learning and whether it ...
Jordan M. Ross, Mounir Bendahmane, Max L. Fletcher   +2 more
doaj   +1 more source

Mapping Glial Autophagy Dynamics in an Amyotrophic Lateral Sclerosis Mouse Model Reveals Microglia and Astrocyte Autophagy Dysfunction

Glia, EarlyView.
In SOD1 mice, symptomatic spinal microglia and astrocytes show increased autophagy flux with greater dysfunction and SOD1 inclusions in astrocytes. Dysfunction was transient (end stage glia displayed control comparable levels of autophagy parameters). ABSTRACT Amyotrophic lateral sclerosis (ALS) is defined by motor neuron death.
Nirma D. Perera, Subhavi De Silva, Doris Tomas, Brittany Cuic, Bradley J. Turner   +4 more
wiley   +1 more source

Cholinergic modulation of hippocampal network function

Frontiers in Synaptic Neuroscience, 2013
Cholinergic septohippocampal projections from the medial septal area to the hippocampus are proposed to have important roles in cognition by modulating properties of the hippocampal network.
Leonor eTeles-Grilo Ruivo, Jack eMellor
doaj   +1 more source

Cholinergic Axons Modulate GABAergic Signaling among Hippocampal Interneurons via Postsynaptic α7 Nicotinic Receptors

Journal of Neuroscience, 2007
Homopentameric α7 nicotinic receptors have a high affinity for acetylcholine (ACh), are permeable to Ca2+ ions, and are abundant in hippocampal interneurons.
N. Wanaverbecq, Alexey Semyanov, I. Pavlov, M. Walker, D. Kullmann   +4 more
semanticscholar   +1 more source

Immunomodulatory natural polysaccharide‐based nanoparticles for the treatment of neurodegenerative diseases

Ibrain, EarlyView.
Polysaccharide‐based nanoparticles offer versatile platforms for drug delivery and immune modulation in neurodegenerative diseases. This review highlights their potential in treating Alzheimer's, Parkinson's, and multiple sclerosis, focusing on targeted delivery and neuroinflammation.
Leto‐Aikaterini Tziveleka, Mariafrancesca Cascione, Paolo Pellegrino, Annalisa Bianco, Stefano Leporatti, Valeria De Matteis   +5 more
wiley   +1 more source

The potential role of environmentally associated DNA methylation in childhood acute lymphoblastic leukaemia subtypes

International Journal of Cancer, EarlyView.
What's New? The rarity of acute lymphoblastic leukaemia and lack of available environmental data have made the role of environmental factors in genetic subtypes challenging to investigate. Here, the authors performed a CpG‐level analysis to investigate DNA methylation as an intermediate mechanism between environmental risk exposures and acute ...
Jessica R. Saville, Lisa J. Russell, Kay Padget, Akram Ghantous, Jessica Nordlund, Jill A. McKay   +5 more
wiley   +1 more source

Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission

Cell Reports, 2018
Summary: Ventral tegmental area (VTA) glutamate neurons are important components of reward circuitry, but whether they are subject to cholinergic modulation is unknown.
Yijin Yan, Can Peng, Matthew C. Arvin, Xiao-Tao Jin, Veronica J. Kim, Matthew D. Ramsey, Yong Wang, Sambashiva Banala, David L. Wokosin, J. Michael McIntosh, Luke D. Lavis, Ryan M. Drenan   +11 more
doaj  

Antinociceptive Activity of Methanolic Extract of Clinacanthus nutans Leaves: Possible Mechanisms of Action Involved

Pain Research and Management, 2018
Methanolic extract of Clinacanthus nutans Lindau leaves (MECN) has been proven to possess antinociceptive activity that works via the opioid and NO-dependent/cGMP-independent pathways.
Zainul Amiruddin Zakaria, Mohammad Hafiz Abdul Rahim, Rushduddin Al Jufri Roosli, Mohd Hijaz Mohd Sani, Maizatul Hasyima Omar, Siti Farah Mohd. Tohid, Fezah Othman, Siew Mooi Ching, Arifah Abdul Kadir   +8 more
doaj   +1 more source

Neuropsychiatric symptoms in siblings of children with Tourette syndrome in the EMTICS study

JCPP Advances, EarlyView.
This multicenter study demonstrated that siblings of children with higher YGTSS score showed a higher level of ASD symptoms. We further report that only female siblings of children with high tic symptom severity showed higher inattention and ODD symptoms.
Olga Sidiropoulou, Jennifer Glaus, Julie Hagstrøm, Setareh Ranjbar, Renata Rizzo, EMTICS collaborative group, Pieter J. Hoekstra, Andrea Dietrich, Kerstin J. Plessen   +8 more
wiley   +1 more source