Cholinergic cells in the nucleus basalis of mice express the N-methyl-D-aspartate-receptor subunit NR2C and its replacement by the NR2B subunit enhances frontal and amygdaloid acetylcholine levels [PDF]
, 2006 It is known that glutamatergic and cholinergic systems interact functionally at the level of the cholinergic basal forebrain. The N-methyl-D-aspartate receptor (NMDA-R) is a multiprotein complex composed of NR1, NR2 and/or NR3 subunits.
Broide R.S. +11 more
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Undifferentiated and differentiated PC12 cells protected by huprines against injury induced by hydrogen peroxide. [PDF]
PLoS ONE, 2013 Oxidative stress is implicated in the pathogenesis of neurodegenerative disorders and hydrogen peroxide (H2O2) plays a central role in the stress. Huprines, a group of potent acetylcholinesterase inhibitors (AChEIs), have shown a broad cholinergic ...
Marta Pera +5 more
doaj +1 more source
Рациональная фармакотерапия в кардиологии, 2015 Aim. To identify the most promising epitopes that simulate various sites β1-adrenergic and M2-cholinergic receptors, and to evaluate their possible contribution to the development and maintenance of cardiac arrhythmias, particularly idiopathic ...
M. M. Rogova +8 more
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The role of spinal adrenergic receptors on the antinociception of ginsenosides in a rat postoperative pain model [PDF]
Korean Journal of Anesthesiology, 2013 BackgroundThe effect of spinal adrenergic and cholinergic receptors on the anti-nociceptive effect of intrathecal ginsenosides was determined in a rat postoperative pain model.MethodsCatheters were placed into the intrathecal space of male Sprague-Dawley
In Ji Kim +3 more
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The binding of botulinum neurotoxins to different peripheral neurons [PDF]
, 2017 Botulinum neurotoxins are the most potent toxins known. The double receptor binding modality represents one of the most significant properties of botulinum neurotoxins and largely accounts for their incredible potency and lethality.
Rossetto, O.
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Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons
Cerebral Cortex, 2016 Corticostriatal regulation of striatal dopamine (DA) transmission has long been postulated, but ionotropic glutamate receptors have not been localized directly to DA axons.
P. Kosillo +3 more
semanticscholar +1 more source
M1 Receptors Mediate Cholinergic Modulation of Excitability in Neocortical Pyramidal Neurons
Journal of Neuroscience, 2009 ACh release into the rodent prefrontal cortex is predictive of successful performance of cue detection tasks, yet the cellular mechanisms underlying cholinergic modulation of cortical function are not fully understood.
Allan T. Gulledge +4 more
semanticscholar +1 more source
Central cholinergic regulation of respiration: nicotinic receptors
Acta Pharmacologica Sinica, 2009 Nicotinic acetylcholine receptors (nAChRs) are expressed in brainstem and spinal cord regions involved in the control of breathing. These receptors mediate central cholinergic regulation of respiration and effects of the exogenous ligand nicotine on ...
X. Shao, J. Feldman
semanticscholar +1 more source
Frontiers in Cellular Neuroscience, 2016 The striatum is the most prominent nucleus in the basal ganglia and plays an important role in motor movement regulation. The cholinergic interneurons (ChIs) in striatum are involved in the motion regulation by releasing acetylcholine (ACh) and ...
Zhe eZhao +8 more
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A Local Circuit Model of Learned Striatal and Dopamine Cell Responses under Probabilistic Schedules of Reward [PDF]
, 2007 Before choosing, it helps to know both the expected value signaled by a predictive cue and the associated uncertainty that the reward will be forthcoming. Recently, Fiorillo et al.
Bullock, Daniel, Tan, Can Ozan
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