Results 81 to 90 of about 2,347,334 (218)

Cholinergic regulation of fear learning and extinction

open access: yesJournal of Neuroscience Research, 2017
Cholinergic activation regulates cognitive function, particularly long‐term memory consolidation. This Review presents an overview of the anatomical, neurochemical, and pharmacological evidence supporting the cholinergic regulation of Pavlovian ...
M. Wilson, J. Fadel
semanticscholar   +1 more source

Structure and dynamics of dynorphin peptide and its receptor [PDF]

open access: yesarXiv, 2019
Dynorphin is a neuropeptide involved in pain, addiction and mood regulation. It exerts its activity by binding to the kappa opioid receptor (KOP) which belongs to the large family of G-protein coupled receptors. The dynorphin peptide was discovered in 1975, while its receptor was cloned in 1993.
arxiv  

Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 1992
The rodent and primate basal forebrain is a target of a family of endogenous peptide signaling molecules, the neurotrophins--nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3--and of the gonadal steroid hormone estrogen, both of ...
C. Toran-Allerand   +6 more
semanticscholar   +1 more source

LOCAL STIMULATION OF α7 CHOLINERGIC RECEPTORS INHIBITS LPS-INDUCED TNF-α RELEASE IN THE MOUSE LUNG

open access: yesShock, 2007
The cholinergic nervous system can inhibit the release of proinflammatory cytokines such as TNF-α from LPS-stimulated macrophages. Acetylcholine, the principal neurotransmitter of the vagus nerve, is the key mediator of this so-called cholinergic anti ...
Ida A. J. Giebelen   +4 more
semanticscholar   +1 more source

The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease.

open access: yesJournal of Neuropathology and Experimental Neurology, 2005
Dysfunction of nerve growth factor (NGF) and its high (TrkA) and low (p75NTR) affinity receptors has been suggested to underlie the selective degeneration of the nucleus basalis (NB) cholinergic cortical projection neurons in end stage Alzheimer disease (
S. Counts, E. Mufson
semanticscholar   +1 more source

Involvement of HCN Channel in Muscarinic Inhibitory Action on Tonic Firing of Dorsolateral Striatal Cholinergic Interneurons

open access: yesFrontiers in Cellular Neuroscience, 2016
The striatum is the most prominent nucleus in the basal ganglia and plays an important role in motor movement regulation. The cholinergic interneurons (ChIs) in striatum are involved in the motion regulation by releasing acetylcholine (ACh) and ...
Zhe eZhao   +8 more
doaj   +1 more source

Protein connectivity in chemotaxis receptor complexes [PDF]

open access: yes, 2015
The chemotaxis sensory system allows bacteria such as Escherichia coli to swim towards nutrients and away from repellents. The underlying pathway is remarkably sensitive in detecting chemical gradients over a wide range of ambient concentrations. Interactions among receptors, which are predominantly clustered at the cell poles, are crucial to this ...
arxiv   +1 more source

Cholinergic Axons Modulate GABAergic Signaling among Hippocampal Interneurons via Postsynaptic α7 Nicotinic Receptors

open access: yesJournal of Neuroscience, 2007
Homopentameric α7 nicotinic receptors have a high affinity for acetylcholine (ACh), are permeable to Ca2+ ions, and are abundant in hippocampal interneurons.
N. Wanaverbecq   +4 more
semanticscholar   +1 more source

Cholinergic modulation of hippocampal network function

open access: yesFrontiers in Synaptic Neuroscience, 2013
Cholinergic septohippocampal projections from the medial septal area to the hippocampus are proposed to have important roles in cognition by modulating properties of the hippocampal network.
Leonor eTeles-Grilo Ruivo, Jack eMellor
doaj   +1 more source

Olfactory Bulb Muscarinic Acetylcholine Type 1 Receptors Are Required for Acquisition of Olfactory Fear Learning

open access: yesFrontiers in Behavioral Neuroscience, 2019
The olfactory bulb (OB) receives significant cholinergic innervation and widely expresses cholinergic receptors. While acetylcholine (ACh) is essential for olfactory learning, the exact mechanisms by which ACh modulates olfactory learning and whether it ...
Jordan M. Ross   +2 more
doaj   +1 more source

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