Results 131 to 140 of about 18,708 (168)
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Cutaneous expression of corticotropin‐releasing hormone (CRH), urocortin, and CRH receptors
The FASEB Journal, 2001ABSTRACT Studies in mammalian skin have shown expression of the genes for corticotropin‐releasing hormone (CRH) and the related urocortin peptide, with subsequent production of the respective peptides. Recent molecular and biochemical analyses have further revealed the presence of CRH receptors (CRH‐Rs). These CRH‐
A, Slominski +6 more
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Human Y-79 retinoblastoma cells express functional corticotropin-releasing hormone receptors
Brain Research, 1992In human Y-79 retinoblastoma cells corticotropin-releasing hormone (CRH) produces a marked and rapid increase of adenylate cyclase activity. The concentration of the peptide producing half-maximal stimulation is 60 nM. The effect of CRH is significantly antagonized by the specific CRH receptor antagonist alpha-helical CHR 9-41 and is mimicked by ...
OLIANAS, MARIA CONCETTA +2 more
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Corticotropin Releasing Hormone, Receptor Regulation and the Stress Response
Trends in Endocrinology & Metabolism, 1998Corticotropin releasing hormone (CRH) coordinates behavioral, autonomic and hormonal responses to stress, including activation of the hypothalamic-pituitary-adrenal (HPA) axis with stimulation of adrenocorticotropin (ACTH) and glucocorticoids.
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Dimerization Between Vasopressin V1b and Corticotropin Releasing Hormone Type 1 Receptors
Cellular and Molecular Neurobiology, 20071. Increasing evidence indicates that guanyl protein coupled receptors (GPCRs), including members of the vasopressin (VP) receptor family can act as homo- and heterodimers. Regulated expression and interaction of pituitary VP V1b receptor (V1bR) and corticotropin releasing hormone receptor type 1 (CRHR1) are critical for hypothalamic pituitary adrenal (
Sharla F, Young +2 more
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Regulation of intermediate pituitary corticotropin-releasing hormone receptors by dopamine.
Endocrinology, 1992It has been shown that chronic cold exposure results in selective CRH receptor up-regulation in the intermediate pituitary. Since the intermediate pituitary is under dopaminergic control, the participation of a dopaminergic mechanism in the effect of cold stress was studied in rats treated with dopaminergic agonists and antagonists.
T, Shiver, M, Familari, G, Aguilera
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Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists
Bioorganic & Medicinal Chemistry Letters, 1999A series of purin-8-ones was prepared and discovered to have excellent binding affinity to the CRH-R1 receptor. Structure-activity studies focused on amine side-chain optimization, urea substitution and pyridyl isostere incorporation. Thus, the highly potent purin-8-ones show promise as a new class of potential anxiolytics and/or antidepressants.
J P, Beck +7 more
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Endotoxin regulates corticotropin-releasing hormone receptor 2 in heart and skeletal muscle
Molecular and Cellular Endocrinology, 1997We tested the effect of endotoxin on the peripheral corticotropin-releasing hormone receptor (CRH-R2), which is highly expressed in the heart. Systemic injection of LPS markedly downregulated CRH-R2 mRNA levels in the heart in a dose and time dependent manner.
K A, Heldwein +4 more
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Corticotropin-Releasing Hormone Receptor Signaling
2003Bhawanjit Brar +2 more
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Presence of corticotropin-releasing-hormone receptor on adrenocortical cells
Experimental and Clinical Endocrinology & Diabetes, 2004HS Willenberg +5 more
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