Results 121 to 130 of about 18,708 (168)
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Corticotropin-releasing hormone receptors
Biochemical Society Transactions, 2002Corticotropin-releasing hormone (CRH) and related peptides (urocortins, sauvagine, urotensin) play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two types of G-protein-coupled receptors encoded by separate genes.
E W, Hillhouse +3 more
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Corticotropin releasing hormone receptors: two decades later
Peptides, 2004Hypothalamic corticotropin releasing hormone (CRH) regulates pituitary ACTH secretion and mediates behavioral and autonomic responses to stress, through interaction with type 1 plasma membrane receptors (CRHR1) located in pituitary corticotrophs and the brain.
Greti, Aguilera +3 more
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Regulation of pituitary corticotropin releasing hormone receptors
Peptides, 2001Corticotropin releasing hormone (CRH) stimulates pituitary ACTH secretion through type-1 CRH (CRH1) receptors. Stimulation of the hypothalamic pituitary adrenal (HPA) axis as well as increased corticotroph responsiveness during stress and adrenalectomy are associated with marked pituitary CRH binding downregulation.
G, Aguilera +2 more
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Corticotropin-releasing hormone receptor subtypes and emotion
Biological Psychiatry, 1999Preclinical data indicate that corticotropin-releasing hormone (CRH) has anxiogenic properties and a dysregulation in CRH systems has been suggested to play a role in a variety of stress-related psychiatric disorders, such as anxiety, depression, and eating disorders.
Steckler, T., Holsboer, F.
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Brain oxytocin receptors mediate corticotropin-releasing hormone-induced anorexia
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1991Central administration of corticotropin-releasing hormone (CRH) is known to inhibit food intake and stimulate pituitary oxytocin (OT) secretion in rats. These experiments addressed the possibility that the inhibition of food intake that follows central CRH administration is mediated through oxytocinergic pathways.
B R, Olson +3 more
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Brain corticotropin-releasing hormone receptors on neurons and astrocytes
Brain Research, 1992Corticotropin-releasing hormone (CRH) exerts many potent effects within brain and is considered an important brain neuroregulator. CRH acts via receptors that are widely distributed throughout brain which exhibits highest CRH receptor concentrations in extrahypothalamic regions.
L P, Kapcala, J A, Dicke
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Corticotropin-Releasing Hormone (CRH) Receptors in Brain
1988Studies with iodine-125-labeled analogues of CRH have identified, characterized, and localized binding sites for CRH in rat and human brain. In addition, we have demonstrated that CRH stimulates cAMP production in various regions of the rat CNS. The significant regional differences in the stoichiometric relationship between receptor number and receptor-
E B, De Souza, G, Battaglia
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Corticotropin-Releasing Hormone Receptor Antagonists: An Update
2009The corticotropin-releasing hormone (CRH) family, CRH, CRH-related peptides and their receptors (R) play major roles in coordinating the behavioral, endocrine, autonomic, and immune responses to stress. The wide influence of the CRH system on physiologic processes in both brain and periphery implicates the respective peptides in the pathophysiology of ...
E, Zoumakis, G P, Chrousos
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Corticotropin-releasing hormone receptor (type I) antisense targeting reduces anxiety
Neuroscience, 1998Two brain-derived corticotropin-releasing hormone receptors have been cloned, termed corticotropin-releasing hormone receptors type I and type 2. Antisense oligodeoxynucleotides targeted to the cloned rat and mouse corticotropin-releasing hormone receptors type I messenger RNA reduced the binding of the natural ligand of the corticotropin-releasing ...
Skutella, T. +4 more
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G protein-coupled corticotropin-releasing hormone receptors in rat retina
Regulatory Peptides, 1995The presence of corticotropin-releasing hormone (CRH) receptors in rat retinal membranes was investigated by using [125I-Tyro]-ovine CRH ([125I]oCRH) as radioligand. The receptor binding was rapid, reversible, saturable and specific. The [125I]oCRH binding was completely displaced by different CRH-related peptides with a rank order of potency similar ...
OLIANAS, MARIA CONCETTA +1 more
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