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Corticotropin-releasing factor type 1 receptors in the rat nodose ganglion are involved in the transduction of stress-induced visceral sensory signals to the brain. [PDF]
Mano-Otagiri A +3 more
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Crosstalk between thyroid hormones and the central corticotropin-releasing factor system in Atlantic salmon. [PDF]
Culbert BM, Jenkins E, Bernier NJ.
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Corticotropin-releasing hormone receptors
Biochemical Society Transactions, 2002Corticotropin-releasing hormone (CRH) and related peptides (urocortins, sauvagine, urotensin) play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two types of G-protein-coupled receptors encoded by separate genes.
E W, Hillhouse +3 more
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Regulation of pituitary corticotropin releasing hormone receptors
Peptides, 2001Corticotropin releasing hormone (CRH) stimulates pituitary ACTH secretion through type-1 CRH (CRH1) receptors. Stimulation of the hypothalamic pituitary adrenal (HPA) axis as well as increased corticotroph responsiveness during stress and adrenalectomy are associated with marked pituitary CRH binding downregulation.
G, Aguilera +2 more
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Corticotropin-releasing hormone receptor subtypes and emotion
Biological Psychiatry, 1999Preclinical data indicate that corticotropin-releasing hormone (CRH) has anxiogenic properties and a dysregulation in CRH systems has been suggested to play a role in a variety of stress-related psychiatric disorders, such as anxiety, depression, and eating disorders.
Steckler, T., Holsboer, F.
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Corticotropin-Releasing Hormone Receptor Antagonists: An Update
2009The corticotropin-releasing hormone (CRH) family, CRH, CRH-related peptides and their receptors (R) play major roles in coordinating the behavioral, endocrine, autonomic, and immune responses to stress. The wide influence of the CRH system on physiologic processes in both brain and periphery implicates the respective peptides in the pathophysiology of ...
E, Zoumakis, G P, Chrousos
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Corticotropin releasing hormone receptors: two decades later
Peptides, 2004Hypothalamic corticotropin releasing hormone (CRH) regulates pituitary ACTH secretion and mediates behavioral and autonomic responses to stress, through interaction with type 1 plasma membrane receptors (CRHR1) located in pituitary corticotrophs and the brain.
Greti, Aguilera +3 more
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Corticotropin-Releasing Hormone (CRH) Receptors in Brain
1988Studies with iodine-125-labeled analogues of CRH have identified, characterized, and localized binding sites for CRH in rat and human brain. In addition, we have demonstrated that CRH stimulates cAMP production in various regions of the rat CNS. The significant regional differences in the stoichiometric relationship between receptor number and receptor-
E B, De Souza, G, Battaglia
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