Results 181 to 190 of about 19,155 (223)
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Role of corticotropin-releasing hormone and receptor in the pathogenesis of psoriasis
Medical Hypotheses, 2009Psoriasis is a chronic inflammatory disease characterized by epidermal keratinocytic hyperproliferation and abnormal differentiation. It is one of the most illustrative examples of the close relation between exacerbation of disease and the psychopathologic burden of the patients. However, the mechanism remains poorly understood.
Chunlei, Zhou +4 more
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Brain corticotropin-releasing hormone receptors on neurons and astrocytes
Brain Research, 1992Corticotropin-releasing hormone (CRH) exerts many potent effects within brain and is considered an important brain neuroregulator. CRH acts via receptors that are widely distributed throughout brain which exhibits highest CRH receptor concentrations in extrahypothalamic regions.
L P, Kapcala, J A, Dicke
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Receptors and Actions of Corticotropin-Releasing Hormone in the Primate Pituitary Gland
The Journal of Clinical Endocrinology & Metabolism, 1987Receptors for CRH were identified in the pituitary gland of several primate species, and their binding characteristics were compared to the ability of CRH to elicit ACTH and cAMP responses in vitro. Autoradiographic analysis of the binding of [125I]Tyr-ovine CRH to frozen pituitary sections revealed CRH receptors in the intermediate and anterior lobes ...
M A, Millan +4 more
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Corticotropin-releasing hormone and its receptors; an evaluation at the transcription level in vivo
Peptides, 2001Activation of the hypothalamic-pituitary-adrenal (HPA) axis is the main defining feature of the stress response. The primary mediator of this response is corticotropin-releasing hormone (CRH), a 41-residue peptide acknowledged as the principal hypophysiotropic factor driving stress-induced adrenocorticotropic hormone (ACTH) secretion.
G, Drolet, S, Rivest
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A corticotropin releasing hormone receptor antagonist does not delay parturition in rats
Journal of Perinatal Medicine, 2000To determine the effects of CP-154, 526, a corticotropin releasing hormone (CRH) receptor antagonist, on the length of normal rat gestation.Twenty-four timed-pregnant Sprague-Dawley rats were purchased for this study. The drug and placebo were administered to the animals using an osmotic pump surgically inserted in the dorsal subcutaneous space.
E F, Funai +4 more
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Corticotropin Releasing Hormone, Receptor Regulation and the Stress Response
Trends in Endocrinology & Metabolism, 1998Corticotropin releasing hormone (CRH) coordinates behavioral, autonomic and hormonal responses to stress, including activation of the hypothalamic-pituitary-adrenal (HPA) axis with stimulation of adrenocorticotropin (ACTH) and glucocorticoids.
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Brain oxytocin receptors mediate corticotropin-releasing hormone-induced anorexia
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1991Central administration of corticotropin-releasing hormone (CRH) is known to inhibit food intake and stimulate pituitary oxytocin (OT) secretion in rats. These experiments addressed the possibility that the inhibition of food intake that follows central CRH administration is mediated through oxytocinergic pathways.
B R, Olson +3 more
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Blockade of corticotropin-releasing hormone receptors reduces spontaneous waking in the rat
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1998We have previously hypothesized that corticotropin-releasing hormone (CRH) is involved in the regulation of physiological waking. To further elucidate this role for CRH, we administered intracerebroventricularly into rats two specific CRH-receptor antagonists, α-helical CRH-(9—41) (α-hCRH) or astressin, and determined changes in electroencephalogram ...
Chang, Fang-Chia, Opp, Mark R.
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Archives of Physiology and Biochemistry, 2002
At least two hypothalamic peptides, corticotropin releasing hormone (CRH) and vasopressin (VP), are important in regulating adrenocorticotropin (ACTH) release from the anterior pituitary. Both are secreted in a pulsatile manner and stimulate ACTH secretion by interacting with G protein-coupled receptors (GPCRs), namely the type 1 CRH receptor and V1b ...
D, Mason +3 more
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At least two hypothalamic peptides, corticotropin releasing hormone (CRH) and vasopressin (VP), are important in regulating adrenocorticotropin (ACTH) release from the anterior pituitary. Both are secreted in a pulsatile manner and stimulate ACTH secretion by interacting with G protein-coupled receptors (GPCRs), namely the type 1 CRH receptor and V1b ...
D, Mason +3 more
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G protein-coupled corticotropin-releasing hormone receptors in rat retina
Regulatory Peptides, 1995The presence of corticotropin-releasing hormone (CRH) receptors in rat retinal membranes was investigated by using [125I-Tyro]-ovine CRH ([125I]oCRH) as radioligand. The receptor binding was rapid, reversible, saturable and specific. The [125I]oCRH binding was completely displaced by different CRH-related peptides with a rank order of potency similar ...
OLIANAS, MARIA CONCETTA +1 more
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