Results 111 to 120 of about 21,979 (167)

Corticotropin-releasing hormone receptors

Biochemical Society Transactions, 2002
Corticotropin-releasing hormone (CRH) and related peptides (urocortins, sauvagine, urotensin) play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two types of G-protein-coupled receptors encoded by separate genes.
E W, Hillhouse, H, Randeva, G, Ladds, D, Grammatopoulos   +3 more
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Corticotropin-releasing factor receptors: An overview

Experimental and Clinical Endocrinology & Diabetes, 2009
Corticotropin-releasing factor (CRF) is the primary physiological regulator of basal and stress-induced release of ACTH, beta-endorphin and other POMC-derived peptides from the pituitary and plays a major role in the brain and periphery in coordinating endocrine, electrophysiological, autonomic, behavioral and immune responses to stress.
K D, Dieterich, H, Lehnert, E B, De Souza   +2 more
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Studies of corticotropin receptors on rat adipocytes

Archives of Biochemistry and Biophysics, 1983
Synthetic [125I]-Tyr23, Phe2, Nle4-adrenocorticotropin (ACTH)-(1-38) [( 125I]-ACTH analog) with full biological potency and near theoretical specific radioactivity (1800 +/- 75 Ci/mmol) was used to investigate ACTH receptors on isolated rat adipocytes derived from 42-day-old rats.
W, Oelofsen, J, Ramachandran
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Desensitization of corticotropin-releasing factor receptors

Biochemical and Biophysical Research Communications, 1983
Pretreatment of rat anterior pituitary cells with corticotropin releasing factor (CRF) rapidly and markedly reduced the ability of CRF to restimulate cyclic AMP formation and adrenocorticotropic hormone (ACTH) release. The effect was dependent on the length of time of pretreatment as well as the concentration of CRF.
T, Reisine, A, Hoffman
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Molecular characterization of a corticotropin (ACTH) receptor

Molecular and Cellular Endocrinology, 1986
We have used a new methodology to generate a monospecific antiserum to the corticotropin (ACTH) receptor on mouse Y-1 adrenal cells. Using immunoaffinity chromatography the ACTH receptor was purified, and the molecular structure and 125I-ACTH binding characteristics were determined.
K L, Bost, J E, Blalock
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Antagonists of the Corticotropin Releasing Factor Receptor

2003
Publisher Summary The current understanding of the corticotropin releasing factor (CRF) system implicates two distinct receptors—potentially multiple endogenous ligands and a binding protein—although the superficial view hides more subtle complexities.
John, Saunders, John, Williams
openaire   +2 more sources

Corticotropin Receptors, Cyclic AMP and Steroidogenesis

Endocrine Research, 1984
The detection and characterization of the physiologically relevant receptors for corticotropin (ACTH) in rat adrenocortical cells is described. By the use of a radioligand with full biological potency and high specific radioactivity (1800 +/- 75 Ci/mmol), a single class of receptors with an apparent Kd of 1.41 +/- 0.21 nM was detected and the number of
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Regulation of pituitary corticotropin releasing hormone receptors

Peptides, 2001
Corticotropin releasing hormone (CRH) stimulates pituitary ACTH secretion through type-1 CRH (CRH1) receptors. Stimulation of the hypothalamic pituitary adrenal (HPA) axis as well as increased corticotroph responsiveness during stress and adrenalectomy are associated with marked pituitary CRH binding downregulation.
G, Aguilera, C, Rabadan-Diehl, M, Nikodemova   +2 more
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Corticotropin-releasing factor receptor antagonists

Expert Opinion on Therapeutic Patents, 2006
Corticotropin-releasing factor (CRF) coordinates the neural, endocrine and immune responses of the body to stress. Therefore, CRF receptors are important targets for the design of drugs for depression, anxiety and stress-related disorders. Several laboratories have published extensive preclinical and limited clinical research into the role of CRF in ...
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Corticotropin Releasing Factor Receptors and Their Ligand Family

Annals of the New York Academy of Sciences, 1999
ABSTRACT:The CRF receptors belong to the VIP/GRF/PTH family of G‐protein coupled receptors whose actions are mediated through activation of adenylate cyclase. Two CRF receptors, encoded by distinct genes, CRF‐R1 and CRF‐R2, and that can exist in two alternatively spliced forms, have been cloned.
M H, Perrin, W W, Vale
openaire   +2 more sources