Results 121 to 130 of about 21,979 (167)

Characterization of Corticotropin Receptors in Human Adrenocortical Cells*

The Journal of Clinical Endocrinology & Metabolism, 1986
[125I-Tyr23,Phe2,Nle4]ACTH-(1-38) ([125I]ACTH analog), which is equipotent with ACTH, was used to characterize ACTH receptors in human adrenocortical cells. Adrenals were obtained from brain-dead patients at the time of renal harvest with permission. Binding of [125I]ACTH analog to human adrenocortical cells was highly specific, rapid, reversible, and ...
R D, Catalano, L, Stuve, J, Ramachandran
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Corticotropin-releasing hormone receptor subtypes and emotion

Biological Psychiatry, 1999
Preclinical data indicate that corticotropin-releasing hormone (CRH) has anxiogenic properties and a dysregulation in CRH systems has been suggested to play a role in a variety of stress-related psychiatric disorders, such as anxiety, depression, and eating disorders.
Steckler, T., Holsboer, F.
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Corticotropin releasing factor receptors

2002
Abstract Throughout life, organisms experience myriad environmental and internal perturbations perceived as ‘stressors’. The diverse strategies used in response to particular stressors are viewed as successful when they restore homeostasis and unsuccessful when they fail to do so and culminate in a disease state.
Marilyn H Perrin, Wylie W Vale
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Corticotropin-Releasing Hormone (CRH) Receptors in Brain

1988
Studies with iodine-125-labeled analogues of CRH have identified, characterized, and localized binding sites for CRH in rat and human brain. In addition, we have demonstrated that CRH stimulates cAMP production in various regions of the rat CNS. The significant regional differences in the stoichiometric relationship between receptor number and receptor-
E B, De Souza, G, Battaglia
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Arylamidrazones as Novel Corticotropin Releasing Factor Receptor Antagonists

Journal of Medicinal Chemistry, 2002
The arylamidrazones have been found to be potent corticotropin releasing factor (CRF) receptor antagonists structurally distinct from previously reported CRF1 antagonists. Attempts to modify the arylamidrazone core suggested an important role for the anilino NH moiety.
Wilson, D.M., Termin, A.P., Mao, L., Ramirez-Weinhouse, M.M., Molteni, V., Grootenhuis, P.D.J., Miller, K.M., Keim, S., Wise, G.   +8 more
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Corticotropin-Releasing Hormone Receptor Antagonists: An Update

2009
The corticotropin-releasing hormone (CRH) family, CRH, CRH-related peptides and their receptors (R) play major roles in coordinating the behavioral, endocrine, autonomic, and immune responses to stress. The wide influence of the CRH system on physiologic processes in both brain and periphery implicates the respective peptides in the pathophysiology of ...
E, Zoumakis, G P, Chrousos
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Corticotropin releasing hormone receptors: two decades later

Peptides, 2004
Hypothalamic corticotropin releasing hormone (CRH) regulates pituitary ACTH secretion and mediates behavioral and autonomic responses to stress, through interaction with type 1 plasma membrane receptors (CRHR1) located in pituitary corticotrophs and the brain.
Greti, Aguilera, Maria, Nikodemova, Peter C, Wynn, Kevin J, Catt   +3 more
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Role of corticotropin-releasing hormone and receptor in the pathogenesis of psoriasis

Medical Hypotheses, 2009
Psoriasis is a chronic inflammatory disease characterized by epidermal keratinocytic hyperproliferation and abnormal differentiation. It is one of the most illustrative examples of the close relation between exacerbation of disease and the psychopathologic burden of the patients. However, the mechanism remains poorly understood.
Chunlei, Zhou, Xiaojing, Yu, Daxing, Cai, Chunxi, Liu, Chunyang, Li   +4 more
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Brain corticotropin-releasing hormone receptors on neurons and astrocytes

Brain Research, 1992
Corticotropin-releasing hormone (CRH) exerts many potent effects within brain and is considered an important brain neuroregulator. CRH acts via receptors that are widely distributed throughout brain which exhibits highest CRH receptor concentrations in extrahypothalamic regions.
L P, Kapcala, J A, Dicke
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An oxidation resistant radioligand for corticotropin-releasing factor receptors

Peptides, 2001
The methionine residues in Tyr-corticotropin-releasing factor (CRF) and Tyr-sauvagine radioligands are subject to oxidation, which renders them biologically inactive. Therefore [Tyr(0,) Gln(1,) Leu(17)]sauvagine (YQLS), in which the methionine was replaced with leucine was synthesized and labeled with (125)Iodine using chloramine-T.
I Q, Assil, M E, Shomali, A B, Abou-Samra   +2 more
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