ABSTRACT Context Screening morning serum cortisol is used to select patients for ACTH stimulation testing to diagnose adrenal insufficiency (AI) but may be affected by pre‐analytical factors. Careful consideration to discontinue confounding medications beforehand may preclude the need for subsequent stimulation testing.
Christopher J. Symonds +2 more
wiley +1 more source
Mast cell corticotropin-releasing factor receptor 1 contributes to pancreatic cancer pain via mitogen-activated protein kinase/sphingosine kinases type 1 signaling. [PDF]
Zhang Y, Wei K, Tao K, Ma M, Lu Z.
europepmc +1 more source
Heterokairic Genes and the Eco‐Evo‐Devo of Timing
Heterokairic genes as the bridge (Heterokairic Pathways?): Heterokairic genes are heterochronic regulators whose activity is modulated by environmental conditions. External cues (e.g., temperature, nutrition, oxygen, density: yellow box) are sensed (yellow arrows) and converted into endocrine and metabolic signals (purple box and arrow into fish's ...
Leandro Lofeu, Ehsan Pashay Ahi
wiley +1 more source
Correction: Nazarloo et al. Oxytocin, Vasopressin and Stress: A Hormetic Perspective. <i>Curr. Issues Mol. Biol.</i> 2025, <i>47</i>, 632. [PDF]
Nazarloo HP +8 more
europepmc +1 more source
Abstract INTRODUCTION Alzheimer's disease (AD) is a heterogeneous disease with diverse disease progression trajectories and brain pathology. Identifying AD subtypes is essential for understanding AD etiology, heterogeneity, and developing precise treatment. METHODS We applied a subspace‐merging algorithm to integrate multi‐omics data from brain tissues
Ziyan Song +5 more
wiley +1 more source
An exploratory microarray analysis of estrogen-mediated gene expression in central pathways that control energy balance in female rats (Rattus norvegicus). [PDF]
Lang H, Burch K, Sloan D.
europepmc +1 more source
NAD+‒circadian rhythm coupling in dementia
Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang +7 more
wiley +1 more source
Correction: CRF1 and ACTH inhibitors are a promising approach to treat obesity and leptin and insulin resistance. [PDF]
Contreras PH, Falhammar H.
europepmc +1 more source
Increased Numbers of CD4+ T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Ling Shan +5 more
wiley +1 more source

