Results 231 to 240 of about 42,487 (284)

Corticotropin-releasing hormone receptors

Biochemical Society Transactions, 2002
Corticotropin-releasing hormone (CRH) and related peptides (urocortins, sauvagine, urotensin) play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two types of G-protein-coupled receptors encoded by separate genes.
E W, Hillhouse, H, Randeva, G, Ladds, D, Grammatopoulos   +3 more
openaire   +2 more sources

Desensitization of corticotropin-releasing factor receptors

Biochemical and Biophysical Research Communications, 1983
Pretreatment of rat anterior pituitary cells with corticotropin releasing factor (CRF) rapidly and markedly reduced the ability of CRF to restimulate cyclic AMP formation and adrenocorticotropic hormone (ACTH) release. The effect was dependent on the length of time of pretreatment as well as the concentration of CRF.
T, Reisine, A, Hoffman
openaire   +2 more sources

Corticotropin-releasing factor receptors: An overview

Experimental and Clinical Endocrinology & Diabetes, 2009
Corticotropin-releasing factor (CRF) is the primary physiological regulator of basal and stress-induced release of ACTH, beta-endorphin and other POMC-derived peptides from the pituitary and plays a major role in the brain and periphery in coordinating endocrine, electrophysiological, autonomic, behavioral and immune responses to stress.
K D, Dieterich, H, Lehnert, E B, De Souza   +2 more
openaire   +2 more sources

Corticotropin-releasing factor receptor antagonists

Expert Opinion on Therapeutic Patents, 2006
Corticotropin-releasing factor (CRF) coordinates the neural, endocrine and immune responses of the body to stress. Therefore, CRF receptors are important targets for the design of drugs for depression, anxiety and stress-related disorders. Several laboratories have published extensive preclinical and limited clinical research into the role of CRF in ...
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Corticotropin releasing factor receptors

2002
Abstract Throughout life, organisms experience myriad environmental and internal perturbations perceived as ‘stressors’. The diverse strategies used in response to particular stressors are viewed as successful when they restore homeostasis and unsuccessful when they fail to do so and culminate in a disease state.
Marilyn H Perrin, Wylie W Vale
openaire   +1 more source

Corticotropin releasing hormone receptors: two decades later

Peptides, 2004
Hypothalamic corticotropin releasing hormone (CRH) regulates pituitary ACTH secretion and mediates behavioral and autonomic responses to stress, through interaction with type 1 plasma membrane receptors (CRHR1) located in pituitary corticotrophs and the brain.
Greti, Aguilera, Maria, Nikodemova, Peter C, Wynn, Kevin J, Catt   +3 more
openaire   +2 more sources

Regulation of pituitary corticotropin releasing hormone receptors

Peptides, 2001
Corticotropin releasing hormone (CRH) stimulates pituitary ACTH secretion through type-1 CRH (CRH1) receptors. Stimulation of the hypothalamic pituitary adrenal (HPA) axis as well as increased corticotroph responsiveness during stress and adrenalectomy are associated with marked pituitary CRH binding downregulation.
G, Aguilera, C, Rabadan-Diehl, M, Nikodemova   +2 more
openaire   +2 more sources

Studies of corticotropin receptors on rat adipocytes

Archives of Biochemistry and Biophysics, 1983
Synthetic [125I]-Tyr23, Phe2, Nle4-adrenocorticotropin (ACTH)-(1-38) [( 125I]-ACTH analog) with full biological potency and near theoretical specific radioactivity (1800 +/- 75 Ci/mmol) was used to investigate ACTH receptors on isolated rat adipocytes derived from 42-day-old rats.
W, Oelofsen, J, Ramachandran
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Corticotropin Receptors, Cyclic AMP and Steroidogenesis

Endocrine Research, 1984
The detection and characterization of the physiologically relevant receptors for corticotropin (ACTH) in rat adrenocortical cells is described. By the use of a radioligand with full biological potency and high specific radioactivity (1800 +/- 75 Ci/mmol), a single class of receptors with an apparent Kd of 1.41 +/- 0.21 nM was detected and the number of
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Corticotropin-releasing hormone receptor subtypes and emotion

Biological Psychiatry, 1999
Preclinical data indicate that corticotropin-releasing hormone (CRH) has anxiogenic properties and a dysregulation in CRH systems has been suggested to play a role in a variety of stress-related psychiatric disorders, such as anxiety, depression, and eating disorders.
Steckler, T., Holsboer, F.
openaire   +3 more sources