Results 241 to 250 of about 42,487 (284)

Molecular characterization of a corticotropin (ACTH) receptor

Molecular and Cellular Endocrinology, 1986
We have used a new methodology to generate a monospecific antiserum to the corticotropin (ACTH) receptor on mouse Y-1 adrenal cells. Using immunoaffinity chromatography the ACTH receptor was purified, and the molecular structure and 125I-ACTH binding characteristics were determined.
K L, Bost, J E, Blalock
openaire   +2 more sources

Antagonists of the Corticotropin Releasing Factor Receptor

2003
Publisher Summary The current understanding of the corticotropin releasing factor (CRF) system implicates two distinct receptors—potentially multiple endogenous ligands and a binding protein—although the superficial view hides more subtle complexities.
John, Saunders, John, Williams
openaire   +2 more sources

Arylamidrazones as Novel Corticotropin Releasing Factor Receptor Antagonists

Journal of Medicinal Chemistry, 2002
The arylamidrazones have been found to be potent corticotropin releasing factor (CRF) receptor antagonists structurally distinct from previously reported CRF1 antagonists. Attempts to modify the arylamidrazone core suggested an important role for the anilino NH moiety.
Wilson, D.M., Termin, A.P., Mao, L., Ramirez-Weinhouse, M.M., Molteni, V., Grootenhuis, P.D.J., Miller, K.M., Keim, S., Wise, G.   +8 more
openaire   +3 more sources

Corticotropin-Releasing Hormone (CRH) Receptors in Brain

1988
Studies with iodine-125-labeled analogues of CRH have identified, characterized, and localized binding sites for CRH in rat and human brain. In addition, we have demonstrated that CRH stimulates cAMP production in various regions of the rat CNS. The significant regional differences in the stoichiometric relationship between receptor number and receptor-
E B, De Souza, G, Battaglia
openaire   +2 more sources

Corticotropin-Releasing Hormone Receptor Antagonists: An Update

2009
The corticotropin-releasing hormone (CRH) family, CRH, CRH-related peptides and their receptors (R) play major roles in coordinating the behavioral, endocrine, autonomic, and immune responses to stress. The wide influence of the CRH system on physiologic processes in both brain and periphery implicates the respective peptides in the pathophysiology of ...
E, Zoumakis, G P, Chrousos
openaire   +2 more sources

Corticotropin Releasing Factor Receptors and Their Ligand Family

Annals of the New York Academy of Sciences, 1999
ABSTRACT:The CRF receptors belong to the VIP/GRF/PTH family of G‐protein coupled receptors whose actions are mediated through activation of adenylate cyclase. Two CRF receptors, encoded by distinct genes, CRF‐R1 and CRF‐R2, and that can exist in two alternatively spliced forms, have been cloned.
M H, Perrin, W W, Vale
openaire   +2 more sources

Characterization of Corticotropin Receptors in Human Adrenocortical Cells*

The Journal of Clinical Endocrinology & Metabolism, 1986
[125I-Tyr23,Phe2,Nle4]ACTH-(1-38) ([125I]ACTH analog), which is equipotent with ACTH, was used to characterize ACTH receptors in human adrenocortical cells. Adrenals were obtained from brain-dead patients at the time of renal harvest with permission. Binding of [125I]ACTH analog to human adrenocortical cells was highly specific, rapid, reversible, and ...
R D, Catalano, L, Stuve, J, Ramachandran
openaire   +2 more sources

[d-Pro5]Corticotropin-releasing factor analogs as selective agonists at corticotropin-releasing factor receptors

European Journal of Pharmacology, 1996
Corticotropin-releasing factor (CRF) acts on at least two types of CRF receptors. To search for selective CRF receptor agonists, 37 ovine CRF analogs, systematically substituted with D-amino acids, were tested for inhibitory activity on edema induced in the pentobarbital-anesthetized rat paw by heat (immersion in 58 degrees C water for 1 min).
E T, Wei, H A, Thomas, J S, Price, T, Kishimoto   +3 more
openaire   +2 more sources

Corticotropin Receptors

Annals of the New York Academy of Sciences, 1987
J, Ramachandran, M, Tsubokawa, K, Gohil
openaire   +2 more sources

Corticotropin-releasing factor receptors: autoradiographic identification.

Research publications - Association for Research in Nervous and Mental Disease, 1986
Our studies on CRF receptors confirm the established role of CRF in regulating pituitary hormone secretion and support a physiological role for endogenous CRF in regulating CNS activity. Studies to characterize CRF receptors and CRF-containing pathways in the brain provide a means for understanding the various functions of this neuropeptide in ...
E B, De Souza, M J, Kuhar
openaire   +1 more source