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Dimerization and signaling of the chemokine receptors CXCR3 and CCX-CKR
, 2012 openaire +1 more source
Exploring the CXCR3 Chemokine Receptor with Small-Molecule Antagonists and Agonists
, 2014 CXCR3 is a CXC chemokine receptor that, together with its three major ligands, CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (I-TAC), is involved in inflammatory responses, mediated mainly by T cells. In several immune-related diseases, including chronic obstructive pulmonary disease (COPD), inflammatory bowel disease (IBD), rheumatoid arthritis, multiple ...
Wijtmans, M. +6 more
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CXCR3 ligands in disease and therapy
Cytokine and Growth Factor Reviews, 2015 Chemokines, binding their various G protein-coupled receptors, lead the way for leukocytes in health and inflammation. Yet chemokine receptor expression is not limited to leukocytes.
Philippe E Van Den Steen +2 more
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The role of IP-10 and its receptor CXCR3 in early pregnancy
Molecular Immunology, 2021The local immune microenvironment of the uterus plays an important role in a successful pregnancy. IP-10 (CXCL10) has been extensively studied in many immune-related diseases. However, the immune role of IP-10 in early pregnancy has not been fully recognized. This study mainly investigated the role of pro-inflammatory chemokine IP-10 in pregnancy.
Ying, Jiang +5 more
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Conformational analysis of the human chemokine receptor CXCR3
Molecular Immunology, 2017In the last years, some studies showed the patho-genetic role of CXCR3 bound to its ligands in many human inflammatory diseases and cancers. Thus, the blockage of the CXCR3 interaction site to its ligands is seen as a possible therapeutic target for the treatment of cancer.
Raffaele, Raucci +4 more
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Hypertension in mice lacking the CXCR3 chemokine receptor
American Journal of Physiology-Renal Physiology, 2009The CXC chemokine receptor 3 (CXCR3) has been linked to autoimmune and inflammatory disease, allograft rejection, and ischemic nephropathy. CXCR3 is expressed on endothelial and smooth muscle cells. Although a recent study posited that antagonizing of CXCR3 function may reduce atherosclerosis, the role of CXCR3 in controlling physiological vascular ...
Hsiang-Hao, Hsu +11 more
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Chemokine Receptor CXCR3: An Unexpected Enigma
2005CXCR3, the receptor for CXCL9/MIG, CXCL10/IP-10, and CXCL11/I-TAC, is preferentially expressed on activated Th1 T cells and has been predicted to play an important role in their trafficking. However, this simplistic view of the function of CXCR3 and its ligands has not been borne out by studies of disease models, including experimental autoimmune ...
Liping, Liu +3 more
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Development of Photoactivatable Allosteric Modulators for the Chemokine Receptor CXCR3
ChemMedChem, 2016AbstractThe CXCR3 receptor, a class A G protein‐coupled receptor (GPCR), is involved in the regulation and trafficking of various immune cells. CXCR3 antagonists have been proposed to be beneficial for the treatment of a wide range of disorders including but not limited to inflammatory and autoimmune diseases.
Tizita Haimanot Admas +3 more
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The chemokine receptors CXCR4 and CXCR3 in cancer
Current Oncology Reports, 2009Chemokines comprise a superfamily of at least 46 cytokines that were initially described based on their ability to bind to 18 to 22 G protein-coupled receptors to induce the directed migration of leukocytes to sites of inflammation or injury. In addition to mediating cellular migration, chemokine/chemokine receptor pairs have been shown to affect many ...
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