Chemokine CXCL10 Modulates the Tumor Microenvironment of Fibrosis-Associated Hepatocellular Carcinoma [PDF]
International Journal of Molecular Sciences, 2022 Hepatocellular carcinoma (HCC) constitutes a devastating health burden. Recently, tumor microenvironment-directed interventions have profoundly changed the landscape of HCC therapy. In the present study, the function of the chemokine CXCL10 during fibrosis-associated hepatocarcinogenesis was analyzed with specific focus on its impact in shaping the ...
Maike Baues +2 more
exaly +5 more sources
CXCL10 Chemokine: A Critical Player in RNA and DNA Viral Infections
Viruses, 2022 Chemokines constitute a group of small, secreted proteins that regulate leukocyte migration and contribute to their activation. Chemokines are crucial inflammatory mediators that play a key role in managing viral infections, during which the profile of ...
Noha Mousaad Elemam +2 more
exaly +5 more sources
Chemokine CXCL10 and Coronavirus-Induced Neurologic Disease. [PDF]
Viral Immunol, 2019 Chemokines (chemotactic cytokines) are involved in a wide variety of biological processes. Following microbial infection, there is often robust chemokine signaling elicited from infected cells, which contributes to both innate and adaptive immune responses that control growth of the invading pathogen.
Skinner D, Marro BS, Lane TE.
europepmc +6 more sources
The role of the Th1 chemokine CXCL10 in vitiligo. [PDF]
Ann Transl Med, 2015 Editorial
Antonelli A, Ferrari SM, Fallahi P.
europepmc +3 more sources
Crystal Structures of Oligomeric Forms of the IP-10/CXCL10 Chemokine [PDF]
Structure, 2003 We have determined the structure of wild-type IP-10 from three crystal forms. The crystals provide eight separate models of the IP-10 chain, all differing substantially from a monomeric IP-10 variant examined previously by NMR spectroscopy. In each crystal form, IP-10 chains form conventional beta sheet dimers, which, in turn, form a distinct ...
Daniel E Holloway +2 more
exaly +3 more sources
Long-Term Exposure of Chemokine CXCL10 Causes Bronchiolitis-like Inflammation [PDF]
American Journal of Respiratory Cell and Molecular Biology, 2012 Abstract Chemokines and chemokine receptors have been implicated in the pathogenesis of bronchiolitis. CXCR3 ligands (CXCL10, CXCL9, and CXCL11) were elevated in patients with bronchiolitis obliterans syndrome (BOS) and chronic allorejection.
Dianhua Jiang +2 more
exaly +3 more sources
Protection mediated by chemokine CXCL10 in BALB/c mice infected by Leishmania infantum. [PDF]
Mem Inst Oswaldo Cruz, 2017 Visceral leishmaniasis (VL) caused by Leishmania infantum is characterised by the loss of the ability of the host to generate an effective immune response. Chemokines have a direct involvement in the pathogenesis of leishmaniasis, causing a rapid change in the expression of these molecules during infection by Leishmania.Herein, it was investigated the ...
Figueiredo WME +6 more
europepmc +6 more sources
Disparate Regions of the Human Chemokine CXCL10 Exhibit Broad-Spectrum Antimicrobial Activity against Biodefense and Antibiotic-Resistant Bacterial Pathogens [PDF]
ACS Infectious Diseases, 2023 Matthew A Crawford +2 more
exaly +2 more sources
Indian Journal of Animal Sciences, 2021 The present investigation was aimed to evaluate novel implication of chemokine genes CXCL10 (C-X-C motif chemokine 10) and CCL 8 (C-C motif chemokine 8) genes for use as ideal pregnancy biomarker in dairy buffaloes.
RAJNI KUMARI +9 more
doaj +1 more source
CXCL10/IP-10 Neutralization Can Ameliorate Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats. [PDF]
PLoS ONE, 2017 The role of C-X-C motif chemokine 10 (CXCL10), a pro-inflammatory factor, in the development of acute respiratory distress syndrome (ARDS) remains unclear.
Shan Lang +8 more
doaj +1 more source