Results 11 to 20 of about 189,065 (308)

Antimicrobial Activity of Chemokine CXCL10 for Dermal and Oral Microorganisms [PDF]

Antibiotics, 2014
CXCL10 (IP-10) is a small 10 kDa chemokine with antimicrobial activity. It is induced by IFN-γ, chemoattracts mononuclear cells, and promotes adhesion of T cells. Recently, we detected CXCL10 on the surface of the skin and in the oral cavity. In the current study, we used broth microdilution and radial diffusion assays to show that CXCL10 inhibits the ...
Grant Holdren, David Rosenthal, Jianyi Yang, Amber Bates, Carol Fischer, Yang Zhang, Nicole Brogden, Kim Brogden   +7 more
semanticscholar   +5 more sources

Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV [PDF]

Journal of Clinical Investigation, 2011
Chronic infection with hepatitis C virus (HCV) is a major public health problem, with nearly 170 million infected individuals worldwide. Current treatment for chronic infection is a combination of pegylated IFN-α2 and ribavirin (RBV); however, this treatment is effective in fewer than 50% of patients infected with HCV genotype 1 or 4.
Casrouge, Armanda, Decalf, Jérémie, Ahloulay, Mina, Lababidi, Cyril, Mansour, Hala, Vallet-Pichard, Anaïs, Mallet, Vincent, Mottez, Estelle, Mapes, James, Fontanet, Arnaud, Pol, Stanislas, Albert, Matthew L.   +11 more
semanticscholar   +6 more sources

Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans [PDF]

International Journal of Inflammation, 2011
Background. The chemokine CXCL10 is specifically upregulated during experimental development of plaque with an unstable phenotype. In this study we evaluated the functional consequences of these findings in mice and humans.Methods and Results. InApoE-/-mice, we induced unstable plaque with using a flow-altering device around the carotid artery.
Segers, D, Lipton, JA, Leenen, PJM, Cheng, C, Tempel, D, Pasterkamp, G, Moll, FL, de Crom, R, Krams, R   +8 more
semanticscholar   +7 more sources

The Inflammatory Chemokine CXCL10 Modulates Synaptic Plasticity and Neuronal Activity in the Hippocampus

European Journal of Inflammation, 2012
Chemokines, a family member of cytokines, have been shown to play a major role in central nervous system inflammation. Among other chemokines, CXCR3 and its ligand CXCL10 are involved in the pathophysiology of several neuroinflammatory conditions.
J.N. Kodangattil, G. Möddel, M. Müller, W. Weber, A. Gorji   +4 more
doaj   +3 more sources

Evaluation of chemokine CXCL10 in human gingival crevicular fluid, saliva, and serum as periodontitis biomarker. [PDF]

J Inflamm Res, 2018
Purpose The aim of this study was to evaluate CXCL10 as a biomarker for periodontitis by determining the CXCL10 levels in saliva, serum, and gingival crevicular fluid (GCF) samples from periodontally healthy control subjects and adult subjects with ...
Aldahlawi S, Youssef AR, Shahabuddin S.
europepmc   +3 more sources

Atorvastatin Reduces Plasma Levels of Chemokine (CXCL10) in Patients with Crohn's Disease

PLoS ONE, 2009
In Crohn's disease high tissue expression and serum levels of chemokines and their receptors are known to correlate with disease activity. Because statins can reduce chemokine expression in patients with coronary diseases, we wanted to test whether this can be achieved in patients with Crohn's disease.We investigated plasma levels of chemokines (CCL2 ...
Olof Grip, Sabina Janciauskiene
semanticscholar   +6 more sources

CXCL10 Is an Agonist of the CC Family Chemokine Scavenger Receptor ACKR2/D6 [PDF]

Cancers, 2021
Atypical chemokine receptors (ACKRs) are important regulators of chemokine functions. Among them, the atypical chemokine receptor ACKR2 (also known as D6) has long been considered as a scavenger of inflammatory chemokines exclusively from the CC family. In this study, by using highly sensitive β-arrestin recruitment assays based on NanoBiT and NanoBRET
Andy Chevigné, Bassam Janji, Max Meyrath, Nathan Reynders, Giulia D’Uonnolo, Tomasz Uchański, Malina Xiao, Guy Berchem, Markus Ollert, Yong-Jun Kwon, Muhammad Zaeem Noman, Martyna Szpakowska   +11 more
openaire   +4 more sources

Bacillus anthracis Peptidoglycan Integrity Is Disrupted by the Chemokine CXCL10 through the FtsE/X Complex. [PDF]

Front Microbiol, 2017
The antimicrobial activity of the chemokine CXCL10 against vegetative cells of Bacillus anthracis occurs via both bacterial FtsE/X-dependent and-independent pathways.
Margulieux KR, Liebov BK, Tirumala VSKKS, Singh A, Bushweller JH, Nakamoto RK, Hughes MA.   +6 more
europepmc   +4 more sources

Pathogen Evasion of Chemokine Response Through Suppression of CXCL10 [PDF]

Frontiers in Cellular and Infection Microbiology, 2019
Clearance of intracellular pathogens, such as Leishmania (L.) major, depends on an immune response with well-regulated cytokine signaling. Here we describe a pathogen-mediated mechanism of evading CXCL10, a chemokine with diverse antimicrobial functions, including T cell recruitment. Infection with L.
Alejandro L. Antonia, Kyle D. Gibbs, Esme D. Trahair, Kelly J. Pittman, Amelia T. Martin, Benjamin H. Schott, Jeffrey S. Smith, Sudarshan Rajagopal, Sudarshan Rajagopal, J. Will Thompson, Richard Lee Reinhardt, Richard Lee Reinhardt, Dennis C. Ko, Dennis C. Ko   +13 more
openaire   +4 more sources

COVID-19 Pulmonary and Olfactory Dysfunctions: Is the Chemokine CXCL10 the Common Denominator?

The Neuroscientist, 2020
COVID-19 is an ongoing viral pandemic that emerged from East Asia and quickly spread to the rest of the world. SARS-CoV-2 is the virus causing COVID-19.
A. Oliviero, F. de Castro, F. Coperchini, L. Chiovato, M. Rotondi   +4 more
semanticscholar   +3 more sources