Results 171 to 180 of about 49,164 (249)

Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1

The Journal of Physiology, EarlyView.
Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang, Pabitra Hriday Patra, Jinquan Yang   +2 more
wiley   +1 more source

Surface Plasmon Resonance as a Potential Diagnostic Tool for the Detection of CXC Chemokine Receptor 4 (CXCR4) on Extracellular Vesicles. [PDF]

Biosensors (Basel)
Verleye K, Noppen S, Boonen A, Yildizhan Y, Van Loy T, Heens C, Vanderhoydonc F, Pinheiro C, Lins PMP, Bronckaers A, Hendrix A, Swinnen JV, Spasic D, Lammertyn J, Pannecouque C, Schols D.   +15 more
europepmc   +1 more source

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

Development of an Optimized CXCR4-Targeting Theranostic Pair. [PDF]

J Nucl Med
Kwon D, Bloise I, Zhang Z, Colpo N, Wilson R, Tan R, Merkens H, Zeisler J, Lau J, Lin KS, Bénard F.   +10 more
europepmc   +1 more source

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Central role of pericytes across major pulmonary diseases. Conceptual wheel diagram illustrating the central role of lung pericytes across diverse pulmonary disease states. A pericyte positioned at the center expresses canonical markers, including PDGFRβ, CD146, and NG2, and connects radially to five major disease contexts.
Stuti Agarwal, Anuradha Bankar, Vinicio A. de Jesus Perez   +2 more
wiley   +1 more source

Modulation of Chemokine Activity for Enhanced Angiogenesis and Tissue Regeneration in Chronic Wounds. [PDF]

Int J Mol Sci
Adit GN, Srikanth K, Harithpriya K, Ganesan K, Ramkumar KM.   +4 more
europepmc   +1 more source

Sphingosine‐1‐Phosphate Receptor 1 Promotes Ovarian Cancer Tumorsphere Proliferation and Metastasis

International Journal of Cancer, Volume 159, Issue 3, Page 768-781, 1 August 2026.
In high‐grade serous ovarian cancer, malignant ascites frequently arise as ovarian cancer cells shed from the primary tumor and aggregate into tumorspheres, severely limiting treatment success. To date, little is known about the mechanisms governing tumorsphere endurance and metastasis within the ascites once formed.
Núria Gendrau‐Sanclemente, Agnès Figueras, Ferran Medina‐Jover, Juan A. Marín‐Jiménez, Michelle De Leeuw, Tianyu Dai, Marina Moreno‐Mosquera, Andrea Morales, Marc Guiu, Josefina Casas, José Carlos Perales, Roger R. Gomis, Francesc Viñals   +12 more
wiley   +1 more source

The role of DPP4 in viral infections: from receptor biology to antiviral target. [PDF]

Arch Virol
Aguilera-Flores C, Arias CF.
europepmc   +1 more source

Circulating Tumor Cells in Multiple Myeloma: From Peripheral Clues to Central Insights

American Journal of Hematology, Volume 101, Issue 7, Page 1575-1588, July 2026.
CTC offer a minimally invasive widow into systemic myeloma biology, overcoming the sampling bias of bone marrow biopsies. Their prognostic value at diagnosis, potential role in MRD monitoring, and ability to capture clonal evolution highlight them as actionable biomarkers for future precision medicine.
Benjamin Podvin, Bruno Paiva, Irene M. Ghobrial, Salomon Manier   +3 more
wiley   +1 more source

High‐Carbohydrate Diet Enhances Peripheral Nerve Regeneration via Hemoglobin Upregulation in Schwann Cells

Food Frontiers, Volume 7, Issue 4, July 2026.
A short‐term high‐carbohydrate diet enhances peripheral nerve regeneration more effectively than high‐protein or high‐fat diets by upregulating hemoglobin genes in Schwann cells. Increased hemoglobin promotes Schwann cell proliferation and migration, facilitating nerve repair.
Shiying Li, Dong Liu, Lin Yu, Yuanyuan Chen, Fuqian Zhang, Xuchao Yan, Yang Qian, Mingwen Zhang, Tianling Song, Jing Zhang, Guifang Wang, Xin Wang, Chunhong Xue, Chen Chen, Guowei Le, Caiping Wang, Dandan Chu   +16 more
wiley   +1 more source