Results 231 to 240 of about 1,196,650 (308)

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Programmed cell death-1: from a T-cell immune checkpoint to a regulator of Natural Killer cell biology. [PDF]

Front Cell Dev Biol
De Franco F, Greppi M, Obino V, Rebaudi F, Goda R, Caffa I, Bozzo M, Melaiu O, Munari E, Vellone VG, Jandus C, Mavilio D, Candiani S, Pesce S, Marcenaro E.   +14 more
europepmc   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Inflammation and Immune Dysregulation Across Respiratory Diseases: From Cellular Mechanisms to Therapeutic Targets. [PDF]

J Inflamm Res
Kumar A, Silveyra P.
europepmc   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Neuroimmune interactions: from molecular mechanisms to therapeutic targets. [PDF]

Mol Biomed
Hao YH, Shi RJ, Tang YL, Liang XH.
europepmc   +1 more source

Extracellular Vesicles from <i>Candida albicans</i> and <i>Aspergillus fumigatus</i> Differentially Integrate PRR and cGAS-STING Signaling to Shape Macrophage Responses. [PDF]

J Fungi (Basel)
Froldi JL, Piraine REA, Tavares LA, Nogueira LFB, Santos P, Almeida F.   +5 more
europepmc   +1 more source

Modulation of TH17 cell activity by REV-ERB agonists: path toward novel treatments for canine meningoencephalitis of unknown origin. [PDF]

npj Vet Sci
Bailey A, Gibson R, Griffett K.
europepmc   +1 more source

Significance of innate immune surveillance in emphysematous pancreatitis. [PDF]

Front Immunol
Zhang W, Wang L, Qin X, Zhang Q, Jin Z.
europepmc   +1 more source