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Current Opinion in Cell Biology, 1991
Cytokines act via receptor-mediated pathways to influence the regulation of both immune and non-immune cells. This review will discuss some of the most important developments over the past year which have contributed to the elucidation of the mechanisms of cell activation by these molecules.
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Cytokines act via receptor-mediated pathways to influence the regulation of both immune and non-immune cells. This review will discuss some of the most important developments over the past year which have contributed to the elucidation of the mechanisms of cell activation by these molecules.
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Trends in Endocrinology & Metabolism, 1994
Cytokines are pleiotropic regulators that control proliferation, differentiation, and other cellular functions. They play a pivotal role in the immune and hematopoietic systems, and subsets of cytokines often exhibit similar biologic activities in common target cells. Recent cloning of genes for the cytokine receptors has provided new insights into the
T, Kitamura, T, Ogorochi, A, Miyajima
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Cytokines are pleiotropic regulators that control proliferation, differentiation, and other cellular functions. They play a pivotal role in the immune and hematopoietic systems, and subsets of cytokines often exhibit similar biologic activities in common target cells. Recent cloning of genes for the cytokine receptors has provided new insights into the
T, Kitamura, T, Ogorochi, A, Miyajima
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Cytokines and Their Receptors: An Overview
Therapeutic Drug Monitoring, 2000Cytokines participate in the induction and effector phases of all immune and inflammatory responses. They are therefore obvious candidates for exploitation as drugs or drug targets to promote, limit, or alter these responses in infection, allergy, autoimmunity, and other disease states.
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Cytokines and their receptor complexes
The FASEB Journal, 1995The 3‐dimensional structures that resulted from X‐ray diffraction and nuclear magnetic resonance analyses of a variety of cytokines are reviewed. These proteins form distinct, well‐defined superfamilies based on the structures of their monomers, even in the absence of significant sequence homology.
D R, Davies, A, Wlodawer
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Keratinocyte Cytokine and Chemokine Receptors
Dermatologic Clinics, 2007Chemokines are a superfamily of small, secreted proteins that regulate cell traffic in homeostatic and inflammatory conditions. Keratinocytes synthesize many chemokines, including members of the CC and CXC subfamilies, such as regulated on activation of normal T-cell expressed and secreted, gamma-interferon inducible protein-10, monokine induced by ...
Tuezuen, Yalcin +3 more
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Nature, 1995
Many cell functions are regulated by members of the cytokine receptor superfamily. Signalling by these receptors depends upon their association with Janus kinases (JAKs), which couple ligand binding to tyrosine phosphorylation of signalling proteins recruited to the receptor complex.
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Many cell functions are regulated by members of the cytokine receptor superfamily. Signalling by these receptors depends upon their association with Janus kinases (JAKs), which couple ligand binding to tyrosine phosphorylation of signalling proteins recruited to the receptor complex.
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Cytokine Receptors of the Lung
American Journal of Respiratory Cell and Molecular Biology, 1991Abstract There has been a dramatic increase in studies on the potential role of cytokines in controlling the processes of inflammation, injury, and repair in the lung. A vast array or network has emerged including all of the cells that produce the various cytokines that have been identified and the target cells that respond to these ...
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Cytokine-Cytokine Receptor Structure
Science, 2005Interleukin-2 (IL-2) is central to the immune response. It forms a complex with three cell surface receptors, IL-2Rα, IL-2Rβ, and IL-2Rγ, to form a complex that signals through activation of downstream tyrosine kinases, JAK3 and STAT. Rickert et al.
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Cytokine Receptors: A New Superfamily of Receptors
1993Publisher Summary This chapter discusses the characteristics that define the structure and composition of the receptors and their ability to bind ligand and transduce signals, known as “signal transduction pathways,” and provides the evidence for oncogenic processes dependent on aberrant cytokine–receptor interactions.
J, Schreurs, D M, Gorman, A, Miyajima
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Strategies to therapeutically modulate cytokine action
Nature reviews. Drug discovery, 2023W. Leonard, Jian-Xin Lin
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