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Dopamine in Health and Disease: Much More Than a Neurotransmitter
Biomedicines, 2021 Dopamine is derived from an amino acid, phenylalanine, which must be obtained through the diet. Dopamine, known primarily to be a neurotransmitter involved in almost any higher executive action, acts through five types of G-protein-coupled receptors ...
Rafael Franco +2 more
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Conformation of dopamine at the dopamine receptor. [PDF]
Proceedings of the National Academy of Sciences, 1978 Tritiated dopamine was used to label the dopamine receptor in membranes isolated from the rat corpus striatum. Scatchard analysis of displacement of [3H]dopamine by nonradioactive dopamine indicated the presence of two binding sites. The similarities in affinity, capacity, and drug specificity of the high-affinity site in the striatal membranes from ...
Duane D. Miller +3 more
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The Role of the Renal Dopaminergic System and Oxidative Stress in the Pathogenesis of Hypertension
Biomedicines, 2021 The kidney is critical in the long-term regulation of blood pressure. Oxidative stress is one of the many factors that is accountable for the development of hypertension.
Waleed N. Qaddumi, Pedro A. Jose
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Dopamine Receptor Signaling [PDF]
Journal of Receptors and Signal Transduction, 2004 The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has shared signaling properties that contribute to the definition of the receptor class, although some differences among subtypes within a class have been identified. D1-like receptor signaling is mediated chiefly by the heterotrimeric G proteins Galphas and Galphaolf ...
Jeremy K. Seamans +2 more
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Decoding the dopamine signal in macaque prefrontal cortex: a simulation study using the Cx3Dp simulator. [PDF]
PLoS ONE, 2013 Dopamine transmission in the prefrontal cortex plays an important role in reward based learning, working memory and attention. Dopamine is thought to be released non-synaptically into the extracellular space and to reach distant receptors through ...
Isabelle Ayumi Spühler, Andreas Hauri
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Evolution of dopamine receptors: phylogenetic evidence suggests a later origin of the DRD2l and DRD4rs dopamine receptor gene lineages [PDF]
PeerJ, 2018 Dopamine receptors are integral membrane proteins whose endogenous ligand is dopamine. They play a fundamental role in the central nervous system and dysfunction of dopaminergic neurotransmission is responsible for the generation of a variety of ...
Juan C. Opazo +3 more
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Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression?
Frontiers in Pharmacology, 2022 Dopamine and its receptors are currently recognized targets for the treatment of several neuropsychiatric disorders, including Parkinson’s disease, schizophrenia, some drug use addictions, as well as depression.
Fangyi Zhao +9 more
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Molecular Brain, 2021 Dopamine is a key neurotransmitter that regulates attention through dopamine D1 and D2-receptors in the prefrontal cortex (PFC). We previously developed an object-based attention test (OBAT) to evaluate attention in mice.
Bolati Wulaer +6 more
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Systemic blockade of dopamine D2-like receptors increases high-voltage spindles in the globus pallidus and motor cortex of freely moving rats. [PDF]
PLoS ONE, 2013 High-voltage spindles (HVSs) have been reported to appear spontaneously and widely in the cortical-basal ganglia networks of rats. Our previous study showed that dopamine depletion can significantly increase the power and coherence of HVSs in the globus ...
Chen Yang +10 more
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Biology, 2021 Dopamine has a variety of physiological roles in the gastrointestinal tract (GI) through binding to Drosophila dopamine D1-like receptors (DARs) and/or adrenergic receptors and has been confirmed as one of the enteric neurotransmitters.
Samar El Kholy +3 more
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