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Dopamine receptor pharmacology
Trends in Pharmacological Sciences, 1994Although antipsychotic drugs originally helped to discover dopamine receptors, the five dopamine receptors presently identified and cloned are facilitating the search for and discovery of more selective antipsychotic and antiparkinson drugs. The D1-like dopamine receptors, D1 and D5, are sensitive to the same drugs as the D1 receptor in native tissues,
P, Seeman, H H, Van Tol
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Multiple receptors for dopamine
Nature, 1979Pharmacological and biochemical criteria can be used to separate those dopamine receptors which are linked to the enzyme adenylyl cyclase and those which are not.
J W, Kebabian, D B, Calne
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Dopamine Receptor and Hypertension
Current Medicinal Chemistry-Cardiovascular & Hematological Agents, 2005Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and reactive oxygen and by interacting with vasopressin, renin-angiotensin, and the sympathetic nervous system. Decreased renal dopamine production and/or impaired dopamine receptor function have been reported in hypertension.
Chunyu, Zeng +3 more
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Dopamine Receptors And Hypertension
Acta Clinica Belgica, 1988Dopamine receptors and ...
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Dopamine receptors and hypertension
Current Hypertension Reports, 2008Dopamine plays an important role in regulating renal function and blood pressure. Dopamine synthesis and dopamine receptor subtypes have been shown in the kidney. Dopamine acts via cell surface receptors coupled to G proteins; the receptors are classified via pharmacologic and molecular cloning studies into two families, D1-like and D2-like.
Anees Ahmad, Banday +1 more
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Dopamine receptors and the dopamine hypothesis of schizophrenia
Synapse, 1987AbstractThe discovery of neuroleptic drugs in 1952 provided a new strategy for seeking a biological basis of schizophrenia. This entailed a search for a primary site of neuroleptic action. The Parkinsonian effects caused by neuroleptics suggested that dopamine transmission may be disrupted by these drugs.
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Dopamine receptor pharmacology
2007Publisher Summary This chapter discusses the basic aspects of dopamine receptor pharmacology and biology. The dopamine receptors, members of the heptahelical G-protein-coupled receptor (GPCR) superfamily, are divided into two subfamilies: the ‘D1-like’ and ‘D2-like’.
Richard B, Mailman, Xuemei, Huang
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Comparative and General Pharmacology, 1971
Abstract 1. 1. This review considers the evidence for specific dopamine receptors in the mammalian peripheral vascular system, the mammalian central nervous system, and in the brain of Helix aspera. 2. 2. From the evidence of structure-activity studies on dog kidney and snail brain it seems that dopamine receptors show a higher degree of ...
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Abstract 1. 1. This review considers the evidence for specific dopamine receptors in the mammalian peripheral vascular system, the mammalian central nervous system, and in the brain of Helix aspera. 2. 2. From the evidence of structure-activity studies on dog kidney and snail brain it seems that dopamine receptors show a higher degree of ...
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Annals of Clinical Psychiatry, 1994
This paper reviews recent developments in dopamine receptor biology, with an emphasis on our recent understanding of the anatomical locations of where various genes for the dopamine receptors are expressed. At least five genes encoding dopamine receptors have been discovered. These five receptors have distinct pharmacological profiles as well as unique
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This paper reviews recent developments in dopamine receptor biology, with an emphasis on our recent understanding of the anatomical locations of where various genes for the dopamine receptors are expressed. At least five genes encoding dopamine receptors have been discovered. These five receptors have distinct pharmacological profiles as well as unique
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Dopamine receptor supersensitivity
Neuroscience & Biobehavioral Reviews, 1995Dopamine (DA) receptor supersensitivity refers to the phenomenon of an enhanced physiological, behavioral or biochemical response to a DA agonist. Literature related to ontogenetic aspects of this process was reviewed. Neonatal 6-hydroxydopamine (6-OHDA) destruction of rat brain DA neurons produces overt sensitization to D1 agonist-induced oral ...
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