Kynurenine pathway dysregulation in attention-deficit hyperactivity disorder: Impact on N-methyl-D-aspartate receptors and phasic dopamine maturation. [PDF]
World J Clin PediatrNagamine T.
europepmc +1 more source
Membrane‐aided simultaneous reaction–separation for liquid phase products
AIChE Journal, EarlyView.Abstract Conventionally, reaction and separation are conducted as separate steps in liquid‐phase manufacturing, with products formed during reaction and subsequently separated from unreacted reagents, solvents, and byproducts. Integrating these steps into a simultaneous reaction–separation process can improve efficiency and reduce costs.
Yihan Song +4 more
wiley +1 more source
Cerebellar Abnormalities in the Neuroimaging Spectrum of CLTC‐Related Disorder
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Pathogenic variants in CLTC, which encodes the clathrin heavy chain involved in vesicle‐mediated trafficking in neurons, cause a rare neurodevelopmental disorder associated with variable severity of global developmental delay and intellectual disability and structural brain abnormalities. Although corpus callosum and white matter anomalies are
Daniel Charouf +7 more
wiley +1 more source
Dopamine receptors in ocular surface biology: Current evidence and future directions. [PDF]
Indian J OphthalmolShetty R +6 more
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Trace Elements Genetics: A Potential Role in Treatment‐Resistant Major Psychoses and Related Traits?
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Trace elements are pivotal to key biological processes, with possible effects on psychopathology. We investigated the hypothesis of shared genetic factors between trace elements levels, treatment resistance and related traits. We used genome‐wide summary statistics for trace elements blood concentration, treatment‐resistant depression (TRD ...
Chiara Fabbri +6 more
wiley +1 more source
The Role of Glutamatergic and Dopaminergic Genes in Resistant Schizophrenia: A Systematic Review
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Psychosis is a heterogeneous disorder, with approximately one‐third of patients experiencing treatment resistance, predominantly among individuals diagnosed with Schizophrenia. Treatment‐resistant schizophrenia (TRS) may stem from a distinct biological signature, involving abnormalities in the dopaminergic and glutamatergic systems.
Maria Teresa Moreno‐Calle +3 more
wiley +1 more source
Dopaminergic genetic variation and response to social comparative feedback when learning a motor sequence task. [PDF]
PLoS OneLewis AF, Bohnenkamp R, Stewart JC.
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Association of DPP4 with esophageal stricture progression and the Hippo‐YAP pathway
Animal Models and Experimental Medicine, EarlyView.This study establishes a comprehensive translational platform for esophageal stricture (ES) research by integrating a novel rat model with clinically relevant porcine validation. This study identifies DPP4 as a gene of interest associated with ES following endoscopic submucosal dissection, demonstrating that prophylactic DPP4 inhibition attenuates ...
Rui Wu +5 more
wiley +1 more source
Smoking Abstinence Elicits Hyperalgesia: Neural Mechanism, Clinical Implications, and Pharmacological Managements. [PDF]
CNS Neurosci TherHu SS, Zhang CF, Lkhagvasuren B, Wang D.
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Animal Models and Experimental Medicine, EarlyView.At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu +3 more
wiley +1 more source