Results 141 to 150 of about 39,913 (215)

Loss of Thy1 in Cortico-Striatal Pathways Alters Response to Dopamine and Gabapentin. [PDF]

ASN Neuro
Goletiani C, McEchron MD, Neely E, Connor JR.   +3 more
europepmc   +1 more source

Targeting the hypothalamic a11 nucleus to treat parkinsonian-like nociceptive impairments. [PDF]

NPJ Parkinsons Dis
Charles KA, Bouali-Benazzouz R, Naudet F, Aby F, Fossat P, Benazzouz A.   +5 more
europepmc   +1 more source

Neurons in a Dish: A Review of In Vitro Cell Models for Studying Neurogenesis

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Different in vitro cell models are valuable to study the different steps of neurogenesis, from the proliferation of neural stem and progenitor cells to the maturation of neurons. Pluripotent stem cells (including embryonic stem cells and induced pluripotent stem cells), immortalized human neuroblastoma cell lines (SH‐SY5Y, IMR‐32), and primary brain ...
Mariana Vassal, Ana C. Cruz, Sandra Rebelo, Filipa Martins   +3 more
wiley   +1 more source

Structural Basis for D3/D4-Selective Antagonism of Piperazinylalkyl Pyrazole/Isoxazole Analogs. [PDF]

Molecules
Choi KE, Jang SH, Park WK, No KT, Koh HY, Pae AN, Cho NC.   +6 more
europepmc   +1 more source

Memantine Confers Multi‐Target Protection in a Zebrafish Seizure Model: Attenuating Epileptic Behavior, GluN2A Overexpression, and Oxidative Stress

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Approximately 30% of epilepsy patients do not respond to current medications. In addition, the pharmaceutical industry is reducing its interest in de novo drug discovery for epilepsy. Drug repurposing offers a promising alternative. This study investigated memantine, an Alzheimer's drug, in a zebrafish model of seizures.
Kamila Cagliari Zenki, Eduardo Kalinine, Ben Hur Marins Mussulini, Thainá Garbino dos Santos, Lucia von Mengden, Fábio Klamt, Suelen Baggio, Ana Carolina de Moura, Ana Beatriz Gorini da Veiga, Diogo Losch de Oliveira   +9 more
wiley   +1 more source

Temporally resolved and interpretable machine learning model of GPCR conformational transition. [PDF]

Nat Commun
Manookian B, Mukhaleva E, Gogoshin G, Bhattacharya S, Sivaramakrishnan S, Vaidehi N, Rodin AS, Branciamore S.   +7 more
europepmc   +1 more source

Unveiling the Proteomic Landscape of Extracellular Vesicles: Implications for Neurodegeneration and Neuroprotection

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Extracellular vesicles (EVs) are tiny, membrane‐covered packets that cells naturally release to send molecular information to one another. In the brain, they function as couriers that move proteins, lipids, and other signals between neurons, glial cells, and the blood–brain barrier.
Berenice N. Bernal‐Vicente, Isaac Ponce, Emmanuel Ríos‐Castro, Perla Moreno‐Castilla, Luis B. Tovar‐y‐Romo   +4 more
wiley   +1 more source

Cilazapril and benazepril mitigate neurodegeneration and α-synuclein accumulation in a cellular model of parkinson's disease. [PDF]

Sci Rep
Altunlu O, Hacimuftuoglu A, Okkay IF, Yesilyurt F, Yoruk MA, Ozkaraca M.   +5 more
europepmc   +1 more source

The gatekeepers of growth: The neural roles and regulation of growth hormone‐releasing hormone neurons

Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.
Abstract The neuroendocrine control of growth is mediated by the hypothalamic–pituitary–somatic (HPS) axis. This involves the hypothalamic release of growth hormone‐releasing hormone (GHRH), which stimulates the pituitary secretion of growth hormone (GH).
Bradley B. Jamieson
wiley   +1 more source

The dopamine paradox in glioblastoma oncology: methylxanthine therapy against nicotine-driven pathogenesis. [PDF]

Ann Med Surg (Lond)
Mursaleen M, Tahir M, Suleman MU, Tabassum SN, Khalil U.   +4 more
europepmc   +1 more source