Results 141 to 150 of about 111,594 (254)

Comorbidity Between Recurrent Major Depressive Disorder and CADASIL: A Case Report With a Brief Review of Published Cases

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) may underlie mood disorders by directly affecting cerebral vascular function and neural networks, thereby contributing to or worsening mood symptoms.
Yi‐meng Wang, Hong‐ye Yu, Ling Zhang, Chen Hu   +3 more
wiley   +1 more source

Dopamine D2 receptor availability is linked to hippocampal–caudate functional connectivity and episodic memory

Proceedings of the National Academy of Sciences of the United States of America, 2016
L. Nyberg, Nina Karalija, Alireza Salami, M. Andersson, A. Wåhlin, Neda Kaboovand, Ylva Köhncke, J. Axelsson, A. Rieckmann, G. Papenberg, D. Garrett, K. Riklund, M. Lövdén, U. Lindenberger, L. Bäckman   +14 more
semanticscholar   +1 more source

Molecular Mechanisms Explaining Neuroanatomical Subtypes in Major Depressive Disorder: Insights From Cortical Morphometric Inverse Divergence

Human Brain Mapping, Volume 46, Issue 16, November 2025.
MIND‐based clustering identified two MDD subtypes with distinct molecular signatures. ABSTRACT Major depressive disorder (MDD) exhibits substantial neurobiological heterogeneity that complicates treatment selection and mechanistic understanding. While conventional group‐level analyses identify diverse structural alterations, they obscure clinically ...
Yao Ge, Lijuan Chen, Yan Bai, Wei Wei, Yu Shen, Kaixin Li, Mengzhu Wang, Meiyun Wang   +7 more
wiley   +1 more source

Drug‐Related Engrams and Their Role in the Persistence and Recurrence of Drug‐Related Behaviors

Hippocampus, Volume 35, Issue 6, November 2025.
ABSTRACT Memory is a cornerstone of human behavior, and addiction offers a compelling model of its persistence and plasticity. The scope of engram research has rapidly expanded to include addiction‐related phenomena. Addiction‐related memories, like strong aversive memories, are often highly resistant to extinction and can continue to drive relapse ...
M. Cutler, A. Thati, S. L. Grella
wiley   +1 more source

Evidence for Noncanonical Neurotransmitter Activation: Norepinephrine as a Dopamine D2-Like Receptor Agonist

Molecular Pharmacology, 2016
Marta Sánchez-Soto, Alessandro Bonifazi, N. Cai, Michael P. Ellenberger, A. Newman, S. Ferré, Hideaki Yano   +6 more
semanticscholar   +1 more source

Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer

Proceedings of the National Academy of Sciences of the United States of America, 2015
J. Bonaventura, Gemma Navarro, Verònica Casadó-Anguera, Karima Azdad, W. Rea, E. Moreno, Marc Brugarolas, J. Mallol, E. Canela, C. Lluis, Antonio Cortés, N. Volkow, S. Schiffmann, S. Ferré, V. Casadó   +14 more
semanticscholar   +1 more source

Advances in Induced Pluripotent Stem Cell Reprogramming and Its Application in Amyotrophic Lateral Sclerosis: A Review

FASEB BioAdvances, Volume 7, Issue 11, November 2025.
iPSC Development and iPSC Application in ALS. ABSTRACT Since Yamanaka's landmark achievement in reprogramming somatic cells into induced pluripotent stem cells (iPSCs) using the four key transcription factors—OCT4, SOX2, KLF4, and c‐Myc (OSKM)—iPSC technology has made significant strides.
Yingliu Luo, Zhenru Xu, Zunxiong Li
wiley   +1 more source

Management of xylazine toxicity, overdose, dependence, and withdrawal: A systematic review

The American Journal on Addictions, Volume 34, Issue 6, Page 589-602, November 2025.
Abstract Background and Objectives Xylazine, an alpha‐2‐adrenergic agonist, has been increasingly implicated in substance use and overdose crises. However, little is known about its effects on humans. With the growing public health crisis surrounding xylazine, it has become important to recognize and promptly manage symptoms of xylazine toxicity ...
Philipa Owusu‐Antwi, Priya Atodaria, Edmund Appiah‐Kubi, Zainab Shah, Elpidio Marlon Garcia   +4 more
wiley   +1 more source

Structural Basis for D3/D4-Selective Antagonism of Piperazinylalkyl Pyrazole/Isoxazole Analogs. [PDF]

Molecules
Choi KE, Jang SH, Park WK, No KT, Koh HY, Pae AN, Cho NC.   +6 more
europepmc   +1 more source

Role of dopamine D2 receptors in plasticity of stress-induced addictive behaviours

Nature Communications, 2013
Hye-ri Sim, Tae-Yong Choi, Hyo Jin Lee, Eun Young Kang, Sehyoun Yoon, P. Han, Se-Young Choi, J. Baik   +7 more
semanticscholar   +1 more source