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The Physiological Role of Dopamine D2 Receptors

1997
Publisher Summary Interest lies in the study of the physiological activity of D2 receptors that are abundantly expressed in the striatum, substantia nigra, and hypophysis. Two isoforms of this receptor have been described that differ by their coupling characteristics to G-proteins in vitro.
Saiardi, Adolfo   +5 more
openaire   +3 more sources

Main interactions of dopamine and risperidone with the dopamine D2 receptor

Physical Chemistry Chemical Physics, 2021
A comparison between dopamine and risperidone shows that weak non-covalent interactions are relevant in understanding the antipsychotic drug mechanism.
Ana Martínez   +4 more
openaire   +2 more sources

Dopamine D2 receptor signaling dynamics of dopamine D2-neurotensin 1 receptor heteromers

Biochemical and Biophysical Research Communications, 2013
Biochemical, histochemical and coimmunoprecipitation experiments have indicated the existence of antagonistic dopamine D2 (D2R) and neurotensin 1 (NTS1R) receptor-receptor interactions in the dorsal and ventral striatum indicating a potential role of these receptor-receptor interactions in Parkinson's disease and schizophrenia.
Borroto Escuela D. O.   +10 more
openaire   +2 more sources

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