Differential roles of dopamine D1 and D2 receptors in pain modulation: a review. [PDF]
Huang M +5 more
europepmc +1 more source
Xanomeline and Trospium Chloride: Mechanism of Action, Clinical, and Translational Science
ABSTRACT Xanomeline‐trospium chloride (Cobenfy, formerly KarXT) is a first‐in‐class, oral central M1/M4 muscarinic receptor agonist approved for the treatment of schizophrenia in adults. Cobenfy represents a paradigm shift by avoiding direct dopamine D2 receptor blockade and thus significantly reduces the burden of metabolic, extrapyramidal, and ...
Samantha Avila, Ingrid L. Chen
wiley +1 more source
Characterization of [<sup>3</sup>H]MCL-524, a Potent Dopamine D<sub>2</sub> <sup>high</sup> Receptor Agonist. [PDF]
Subburaju S +3 more
europepmc +1 more source
Summary Background The diagnosis and management of pituitary pars intermedia dysfunction (PPID) in horses includes evaluating abnormal plasma concentrations of adrenocorticotrophic hormone (ACTH). Treatment commonly includes the oral dopamine agonist pergolide mesylate, which suppresses the pathologic overproduction of ACTH.
A. Bracken +5 more
wiley +1 more source
Dopamine Receptor Modulation in Co-Occurring Disorders: Potential of Cariprazine and D3 Receptor Activity. [PDF]
Lynch ST, Mariani JJ, Levin FR.
europepmc +1 more source
Continuous MCP dosing was associated with higher TD prevalence and earlier onset. Intermittent dosing, despite longer cumulative exposure, was associated with lower TD risk. These findings suggest that intermittent regimens may offer a safer MCP therapeutic strategy. ABSTRACT Background Tardive dyskinesia (TD) is an often irreversible movement disorder
Pierantonio Russo +2 more
wiley +1 more source
Dopaminergic-Nitrergic Microcircuitry in the Paraventricular Nucleus: Translational Relevance for Psychiatric Practice. [PDF]
Kong SS, Wei LC.
europepmc +1 more source
Dopaminergic genetic variation and response to social comparative feedback when learning a motor sequence task. [PDF]
Lewis AF, Bohnenkamp R, Stewart JC.
europepmc +1 more source
Striatal remodeling in Parkinson disease. [PDF]
Emerson SD +3 more
europepmc +1 more source
Identification of novel peripherally restricted risperidone-like dopamine D2 receptor antagonists for prolactin-mediated neuroprotection through a multi-stage in silico screening. [PDF]
Kim S, Jo WH, Cha JO, Kim MS.
europepmc +1 more source

