Results 171 to 180 of about 41,424 (223)
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1992
Dopamine is the dominant catecholamine neurotransmitter in the mammalian brain. It is found throughout the entire central nervous system, but is predominant in the nigrostriatal, mesolimbic, and tuberoinfundibular tracts (Creese et al., 1983). Dopamine exerts its effects through binding to two types of receptor, the D1 and D2 receptors (Kebabian and ...
Olivier Civelli +4 more
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Dopamine is the dominant catecholamine neurotransmitter in the mammalian brain. It is found throughout the entire central nervous system, but is predominant in the nigrostriatal, mesolimbic, and tuberoinfundibular tracts (Creese et al., 1983). Dopamine exerts its effects through binding to two types of receptor, the D1 and D2 receptors (Kebabian and ...
Olivier Civelli +4 more
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D2 dopamine receptor gene and alcoholism
Journal of Psychiatric Research, 1993An allelic association of the TAQ I A1 D2 dopamine receptor gene polymorphism has been found in homogeneous populations of alcoholics from France.
Stéphane Amadéo +12 more
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Synthesis and processing of D2 dopamine receptors
Biochemistry, 1993Dopamine receptors belong to a superfamily of neurotransmitter receptors that are functionally coupled to guanine nucleotide binding proteins. In this study, we have used Chinese hamster ovary (CHO) cells stably transfected with the rat D2L receptor, in conjunction with specific anti-peptide antibodies that we have developed, in order to visualize this
C, David +4 more
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The dopamine D2 antagonist remoxipride acts in vivo on a subpopulation of dopamine D2 receptors
Neuroscience, 1994Dopamine D2 receptors were inactivated by N-ethoxycarbonyl-2-ethoxy-1,2,-dihydroxy-quinoline (EEDQ) (6 mg/kg i.p.). The reduction in dopamine receptors was monitored by quantitative receptor autoradiography using [125I]iodosulpiride or [3H]raclopride as radioligands.
S O, Ogren, L, Rosén, K, Fuxe
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Dopamine D2 Receptors in Signal Transduction and Behavior
Critical Reviews™ in Neurobiology, 1997The dopamine D2 receptor belongs to the family of seven transmembrane domain G-protein-coupled receptors and is highly expressed in the central nervous system and the pituitary gland. The binding of dopamine to the D2 receptor is crucial for the regulation of diverse physiological functions, such as the control of locomotor activity and the synthesis ...
Picetti +5 more
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Aspects of the structure of the D2 dopamine receptor
Trends in Neurosciences, 1990Significant new information on the D2 dopamine receptor has recently become available from a combination of protein chemical and molecular genetic analyses. Molecular genetic studies have shown the receptor to be a member of the family of receptors that are linked to G proteins and that have structures predicted to contain seven transmembrane domains ...
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Dopamine D2 Receptor and Tourette's Syndrome
Archives of Neurology, 1995I was pleased to see the study by Gelernter et al 1 concerning the role of the dopamine D 2 receptor ( DRD2 ) gene in Tourette syndrome (TS) because the authors so nicely verified our previous studies demonstrating a role the DRD2 gene in TS and because they illustrated some of the issues concerning association vs linkage studies in neuropsychiatric ...
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Olfactory receptor neurons express D2 dopamine receptors
The Journal of Comparative Neurology, 1999The role of the dopamine (DA) in the olfactory bulb (OB) was explored by determining which of the potential target cells express dopamine receptors (DARs). Previously, it was reported that D2-like DAR (D2, D3, and D4 subtypes) radioligand binding is restricted to the outer layers of the OB.
N L, Koster +6 more
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Dopamine D2 Receptor Dimers and Receptor-Blocking Peptides
Biochemical and Biophysical Research Communications, 1996Dopamine D2 receptors exist as dimers in whole cell lysate, crude membranes prepared from human caudate, and following solubilization and immunoprecipitation of the receptor from these tissues. Photoaffinity labelling experiments confirmed that D2 receptors exist either as monomers that are selective targets for spiperone or as dimers that are targets ...
G Y, Ng +6 more
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Modulation of dopamine metabolism in the retina via dopamine D2 receptors
Brain Research, 1990When rats are placed in a lighted environment from the dark retinal DOPAC increases. There is no significant change of retinal dopamine (DA) under either lighting condition. Blockade of aromatic L-amino acid decarboxylase results in a more rapid accumulation of DOPA in the retina of animals in the light than in the dark implying that DA synthesis and ...
M, Hadjiconstantinou +3 more
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