Results 171 to 180 of about 147,933 (225)

2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as D₃R-Selective Ligands for 3D-QSAR, Docking and Molecular Dynamics Simulation Studies. [PDF]

Int J Mol Sci
Guo L, Gao Y, Zhang S, Zhao L, Zhao R, Sun P, Pan X, Zhang W.   +7 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Dopamine D2 Receptors as Treatment Targets in Schizophrenia

Clinical Schizophrenia & Related Psychoses, 2010
The antipsychotic effectiveness of chlorpromazine and haloperidol started a search for their therapeutic targets. The antipsychotic receptor target turned out to be a dopamine receptor, now cloned as the dopamine D2 receptor. The D2 receptor is the common target for antipsychotics.
P. Seeman
openaire   +3 more sources

Dopamine D2 receptor signaling dynamics of dopamine D2-neurotensin 1 receptor heteromers

Biochemical and Biophysical Research Communications, 2013
Biochemical, histochemical and coimmunoprecipitation experiments have indicated the existence of antagonistic dopamine D2 (D2R) and neurotensin 1 (NTS1R) receptor-receptor interactions in the dorsal and ventral striatum indicating a potential role of these receptor-receptor interactions in Parkinson's disease and schizophrenia.
Ismel Brito, Ismel Brito, Alexander O. Tarakanov, Fidel Corrales, Luigi F. Agnati, Kjell Fuxe, Wilber Romero-Fernandez, Luca Ferraro, Sergio Tanganelli, Dasiel O. Borroto-Escuela, Annalisa Ravani, Manuel Narváez   +11 more
openaire   +3 more sources

Main interactions of dopamine and risperidone with the dopamine D2 receptor

Physical Chemistry Chemical Physics, 2021
A comparison between dopamine and risperidone shows that weak non-covalent interactions are relevant in understanding the antipsychotic drug mechanism.
Ana Martínez, Ponciano García-Gutiérrez, Rafael A. Zubillaga, Jorge Garza, Rubicelia Vargas   +4 more
openaire   +3 more sources

The Physiological Role of Dopamine D2 Receptors

1997
Publisher Summary Interest lies in the study of the physiological activity of D2 receptors that are abundantly expressed in the striatum, substantia nigra, and hypophysis. Two isoforms of this receptor have been described that differ by their coupling characteristics to G-proteins in vitro.
Saiardi Adolfo, Samad Tarek Abdel, Picetti Roberto, Bozzi Yuri, Baik JaHyun, Borrelli Emiliana   +5 more
openaire   +4 more sources

The Dopamine D2 Receptor

1992
Dopamine is the dominant catecholamine neurotransmitter in the mammalian brain. It is found throughout the entire central nervous system, but is predominant in the nigrostriatal, mesolimbic, and tuberoinfundibular tracts (Creese et al., 1983). Dopamine exerts its effects through binding to two types of receptor, the D1 and D2 receptors (Kebabian and ...
Hubert H.M. Van Tol, Paul R. Albert, Olivier Civelli, James R. Bunzow, David K. Grandy   +4 more
openaire   +2 more sources

D2 and D4 dopamine receptor polymorphisms and personality [PDF]

American Journal of Medical Genetics, 1998
The relationship of various dimensions of temperament, measured by the Tridimensional Personality Questionnaire (TPQ), to polymorphisms of the D2 dopamine receptor (DRD2) and D4 dopamine receptor (DRD4) genes was determined in 119 healthy Caucasian boys who had not yet begun to consume alcohol and other drugs of abuse.
Terry Ritchie, Ernest P. Noble, Tulin Ozkaragoz, Xuxian Zhang, Robert S. Sparkes, Thomas R. Belin   +5 more
openaire   +2 more sources

Synthesis and processing of D2 dopamine receptors

Biochemistry, 1993
Dopamine receptors belong to a superfamily of neurotransmitter receptors that are functionally coupled to guanine nucleotide binding proteins. In this study, we have used Chinese hamster ovary (CHO) cells stably transfected with the rat D2L receptor, in conjunction with specific anti-peptide antibodies that we have developed, in order to visualize this
David R. Sibley, Fishburn Cs, Sara Fuchs, Carol David, Monsma Fj   +4 more
openaire   +3 more sources

Dopamine receptors: from structure to function.

Physiological Reviews, 1998
The diverse physiological actions of dopamine are mediated by at least five distinct G protein-coupled receptor subtypes. Two D1-like receptor subtypes (D1 and D5) couple to the G protein Gs and activate adenylyl cyclase.
C. Missale, S. Nash, S. Robinson, M. Jaber, M. Caron   +4 more
semanticscholar   +1 more source

D2 dopamine receptor gene and alcoholism

Journal of Psychiatric Research, 1993
An allelic association of the TAQ I A1 D2 dopamine receptor gene polymorphism has been found in homogeneous populations of alcoholics from France.
Didier Castelnau, Yves Leclaire, Jean-Claude Champiat, Michel Selin, Mokrane Abbar, Marie Gaelle Leroux, Gilles Waksman, Jacques Mallet, Andree Madec, Stéphane Amadéo, Marie Line Fourcade, Annie Brethome, Jean-Luc Venisse   +12 more
openaire   +3 more sources