Results 11 to 20 of about 147,933 (225)

Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers. [PDF]

PLoS ONE, 2013
Under normal conditions the brain maintains a delicate balance between inputs of reward seeking controlled by neurons containing the D1-like family of dopamine receptors and inputs of aversion coming from neurons containing the D2-like family of dopamine
Gemma Navarro, Estefania Moreno, Jordi Bonaventura, Marc Brugarolas, Daniel Farré, David Aguinaga, Josefa Mallol, Antoni Cortés, Vicent Casadó, Carmen Lluís, Sergi Ferre, Rafael Franco, Enric Canela, Peter J McCormick   +13 more
doaj   +2 more sources

Genetically Determined Measures of Striatal D2 Signaling Predict Prefrontal Activity during Working Memory Performance [PDF]

PLoS ONE, 2010
Background: Variation of the gene coding for D2 receptors (DRD2) has been associated with risk for schizophrenia and with working memory deficits. A functional intronic SNP (rs1076560) predicts relative expression of the two D2 receptors isoforms, D2S ...
Bertolino, Alessandro, Bianco, Luciana Lo, Blasi, Giuseppe, Caforio, Grazia, Di Giorgio, Annabella, Fazio, Leonardo, Gelao, Barbara, Lozupone, Madia, Niccoli-Asabella, Artor, Papp, Audrey, Pisciotta, Nicola Marco, Popolizio, Teresa, Romano, Raffaella, Rubini, Giuseppe, Sadee, Wolfgang, Sambataro, Fabio, Sinibaldi, Lorenzo, Taurisano, Paolo, Ursini, Gianluca   +18 more
core   +11 more sources

A Novel Dopamine Receptor Signaling Unit in Brain: Heterooligomers of D1 And D2 Dopamine Receptors [PDF]

The Scientific World Journal, 2007
The ability of G protein coupled receptors to heterooligomerize and create novel signaling complexes has demonstrated the tremendous potential of these receptors to access diverse signaling cascades, as well as to modulate the nature of the transduced ...
Brian F. O'Dowd, Susan R. George
core   +2 more sources

Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance [PDF]

Molecular Brain, 2011
Dopamine is an important catecholamine neurotransmitter modulating many physiological functions, and is linked to psychopathology of many diseases such as schizophrenia and drug addiction.
George, Susan R, Hasbi, Ahmed, O'Dowd, Brian F   +2 more
core   +5 more sources

Dissociable Effects of Dopamine on Neuronal Firing Rate and Synchrony in the Dorsal Striatum [PDF]

Frontiers in Integrative Neuroscience, 2009
Previous studies showed that dopamine depletion leads to both changes in firing rate and in neuronal synchrony in the basal ganglia. Since dopamine D1 and D2 receptors are preferentially expressed in striatonigral and striatopallidal medium spiny neurons,
John M Burkhardt, John M Burkhardt, Rui M Costa, Rui M Costa, Xin Jin   +4 more
core   +5 more sources

Dopaminergic Presynaptic Modulation of Nigral Afferents: Its Role in the Generation of Recurrent Bursting in Substantia Nigra Pars Reticulata Neurons [PDF]

Frontiers in Systems Neuroscience, 2011
Previous work has shown the functions associated with activation of dopamine presynaptic receptors in some substantia nigra pars reticulata (SNr) afferents: (i) striatonigral terminals (direct pathway) posses presynaptic dopamine D1-class receptors whose
Bargas, José, de Jesús Aceves, José, Galarraga, Elvira, Hernández, Ricardo, Ibañez-Sandoval, Osvaldo, Plata, Víctor, Rueda-Orozco, Pavel E.   +6 more
core   +5 more sources

Dichotomous Dopaminergic Control of Ventral Pallidum Neurons [PDF]

Frontiers in Cellular Neuroscience, 2017
The ventral pallidum (VP) is crucially involved in reward processing. Dopaminergic afferents reach the VP from the ventral tegmental area (VTA). Recent in vivo studies suggest dopamine application increase the firing in the VP.
Clark, Martin, Bracci, Enrico
core   +9 more sources

Dopamine presynaptically and heterogeneously modulates nucleus accumbens medium-spiny neuron GABA synapses in vitro [PDF]

BMC Neuroscience, 2006
BACKGROUND: The striatal complex is the major target of dopamine action in the CNS. There, medium-spiny GABAergic neurons, which constitute about 95% of the neurons in the area, form a mutually inhibitory synaptic network that is modulated by dopamine ...
Feldman, Igor G, Geldwert, Daron, Joyce, Myra P, Norris, J Madison, Rayport, Stephen, Schulman, Joshua J   +5 more
core   +6 more sources

Dopamine signaling in food addiction: role of dopamine D2 receptors

BMB Reports, 2013
Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic dopaminergic pathway. Changes in DA signaling in mesolimbic neurotransmission are widely believed to modify reward-related behaviors and are therefore closely associated with drug addiction.
J. Baik
openaire   +5 more sources

Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson's disease revealed by in vivo PET imaging. [PDF]

Sci Rep
We conducted PET imaging with [18F]FDOPA and dopamine D2/3 receptor ligand [18F]fallypride in aged transgenic rats carrying human pathogenic LRRK2 R1441C or G2019S mutations.
Delgado-Goñi T, Connor-Robson N, Cioroch M, Paisey S, Marshall C, Lane EL, Hauton D, McCullagh J, Magill PJ, Cragg SJ, Mackay CE, Wade-Martins R, Klein JC.   +12 more
europepmc   +2 more sources