Results 191 to 200 of about 39,913 (215)
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Dopamine D2 Receptor Dimers and Receptor-Blocking Peptides
Biochemical and Biophysical Research Communications, 1996Dopamine D2 receptors exist as dimers in whole cell lysate, crude membranes prepared from human caudate, and following solubilization and immunoprecipitation of the receptor from these tissues. Photoaffinity labelling experiments confirmed that D2 receptors exist either as monomers that are selective targets for spiperone or as dimers that are targets ...
G Y, Ng +6 more
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D2 dopamine receptor involvement in spinal dopamine-produced antinociception
Life Sciences, 1992Experiments were performed on 79 lightly pentobarbital-anesthetized rats. Rats displayed a dose-dependent increase in tail-flick latencies following the injection of dopamine (DA) into the lumbar subarachnoid space through an intrathecal tube. Sulpiride, a D2-subtype receptor antagonist, antagonized the DA-induced analgesia (antinociceptive) effect ...
Q S, Liu, J T, Qiao, N, Dafny
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The Physiological Role of Dopamine D2 Receptors
1997Publisher Summary Interest lies in the study of the physiological activity of D2 receptors that are abundantly expressed in the striatum, substantia nigra, and hypophysis. Two isoforms of this receptor have been described that differ by their coupling characteristics to G-proteins in vitro.
Saiardi Adolfo +5 more
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Dopamine D2 Receptor and Tourette's Syndrome
Archives of Neurology, 1995I was pleased to see the study by Gelernter et al 1 concerning the role of the dopamine D 2 receptor ( DRD2 ) gene in Tourette syndrome (TS) because the authors so nicely verified our previous studies demonstrating a role the DRD2 gene in TS and because they illustrated some of the issues concerning association vs linkage studies in neuropsychiatric ...
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D2 dopamine receptor localization on striatonigral neurons
Neuroscience Letters, 1992Two major pharmacological classes of dopamine receptors exist in the central nervous system. These receptors have been designated as D1 or D2 based upon their differing pharmacology and influence on the cyclic AMP second messenger system. Different genes for the D1 and D2 dopamine receptors have been isolated and are found to be expressed in high ...
M A, Ariano +3 more
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Dopamine D2 Receptor Function Unraveled
Science's STKE, 2004Cortical dopaminergic systems are involved in normal and abnormal cognition. Dopaminergic D2 antagonists are widely used in the treatment of schizophrenia. During the performance of tasks requiring working memory, cells in the frontal cortex discharge in relation to the memory period or in relation to guided memory saccades. Wang
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Dopamine D2/D3 receptor availability and venturesomeness
Psychiatry Research: Neuroimaging, 2011The construct of impulsivity is considered as a major trait of personality. There is growing evidence that the mesolimbic dopamine system plays an important role in the modulation of impulsivity and venturesomeness, the two key components within the impulsivity-construct.
Nina, Bernow +10 more
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Dopamine-D2-receptor-agonists/dopamine-D2-receptor-partial-agonists
Reactions Weekly, 2022openaire +1 more source
Dopamine D1/D2 Receptor Interaction
Psychiatry and Clinical Neurosciences, 1991M, Sasa +4 more
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D2 Dopamine Receptors and Schizophrenia
1991The dopamine hypothesis of schizophrenia postulates that an elevation of the D2 dopamine receptor density could be part of the pathophysiology of the disease. To assess this question, in vivo studies of the D2 receptors have been performed in drug-free schizophrenics using positron emission tomography.
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