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Dopamine D2 Receptors as Treatment Targets in Schizophrenia
Clinical Schizophrenia & Related Psychoses, 2010The antipsychotic effectiveness of chlorpromazine and haloperidol started a search for their therapeutic targets. The antipsychotic receptor target turned out to be a dopamine receptor, now cloned as the dopamine D2 receptor. The D2 receptor is the common target for antipsychotics.
P. Seeman
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Dopamine D2 receptor signaling dynamics of dopamine D2-neurotensin 1 receptor heteromers
Biochemical and Biophysical Research Communications, 2013Biochemical, histochemical and coimmunoprecipitation experiments have indicated the existence of antagonistic dopamine D2 (D2R) and neurotensin 1 (NTS1R) receptor-receptor interactions in the dorsal and ventral striatum indicating a potential role of these receptor-receptor interactions in Parkinson's disease and schizophrenia.
Ismel Brito +11 more
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Main interactions of dopamine and risperidone with the dopamine D2 receptor
Physical Chemistry Chemical Physics, 2021A comparison between dopamine and risperidone shows that weak non-covalent interactions are relevant in understanding the antipsychotic drug mechanism.
Ana Martínez +4 more
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The Physiological Role of Dopamine D2 Receptors
1997Publisher Summary Interest lies in the study of the physiological activity of D2 receptors that are abundantly expressed in the striatum, substantia nigra, and hypophysis. Two isoforms of this receptor have been described that differ by their coupling characteristics to G-proteins in vitro.
Saiardi Adolfo +5 more
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1992
Dopamine is the dominant catecholamine neurotransmitter in the mammalian brain. It is found throughout the entire central nervous system, but is predominant in the nigrostriatal, mesolimbic, and tuberoinfundibular tracts (Creese et al., 1983). Dopamine exerts its effects through binding to two types of receptor, the D1 and D2 receptors (Kebabian and ...
Hubert H.M. Van Tol +4 more
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Dopamine is the dominant catecholamine neurotransmitter in the mammalian brain. It is found throughout the entire central nervous system, but is predominant in the nigrostriatal, mesolimbic, and tuberoinfundibular tracts (Creese et al., 1983). Dopamine exerts its effects through binding to two types of receptor, the D1 and D2 receptors (Kebabian and ...
Hubert H.M. Van Tol +4 more
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D2 and D4 dopamine receptor polymorphisms and personality [PDF]
American Journal of Medical Genetics, 1998 The relationship of various dimensions of temperament, measured by the Tridimensional Personality Questionnaire (TPQ), to polymorphisms of the D2 dopamine receptor (DRD2) and D4 dopamine receptor (DRD4) genes was determined in 119 healthy Caucasian boys who had not yet begun to consume alcohol and other drugs of abuse.
Terry Ritchie +5 more
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Synthesis and processing of D2 dopamine receptors
Biochemistry, 1993Dopamine receptors belong to a superfamily of neurotransmitter receptors that are functionally coupled to guanine nucleotide binding proteins. In this study, we have used Chinese hamster ovary (CHO) cells stably transfected with the rat D2L receptor, in conjunction with specific anti-peptide antibodies that we have developed, in order to visualize this
David R. Sibley +4 more
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D2 dopamine receptor gene and alcoholism
Journal of Psychiatric Research, 1993An allelic association of the TAQ I A1 D2 dopamine receptor gene polymorphism has been found in homogeneous populations of alcoholics from France.
Didier Castelnau +12 more
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Dopamine D2 Receptors in Signal Transduction and Behavior
Critical Reviews™ in Neurobiology, 1997The dopamine D2 receptor belongs to the family of seven transmembrane domain G-protein-coupled receptors and is highly expressed in the central nervous system and the pituitary gland. The binding of dopamine to the D2 receptor is crucial for the regulation of diverse physiological functions, such as the control of locomotor activity and the synthesis ...
Picetti +5 more
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