Results 201 to 210 of about 150,460 (322)

Inhibitory effects of dopamine agonists on pain-responsive neurons in the central nucleus of the amygdala. [PDF]

J Neurophysiol
Heuermann RJ, Gereau RW.
europepmc   +1 more source

Atypical onset of obsessive‐compulsive disorder at age 50 following post‐SARS‐COV‐2 syndrome: A case report

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 3, September 2025.
Abstract Background The coronavirus disease 2019 (SARS‐COV‐2) pandemic has been associated with an increased risk of developing or exacerbating obsessive‐compulsive disorder (OCD). This report presents a case of OCD onset in a 50‐year‐old male following recovery from acute SARS‐COV‐2 infection, highlighting the potential neuroinflammatory and ...
Tomoko Sugawara, Rie Ichiki
wiley   +1 more source

Astrocyte in Neurological Disease: Pathogenesis and Therapy

MedComm, Volume 6, Issue 8, August 2025.
This review provides comprehensive overview of astrocytes in neurological disorders. Astrocytes contribute to neurological disorders via A1/A2 polarization, inducing neuroinflammation, synaptic, and BBB dysfunction. Metabolic disturbances in glucose, lipid, and amino acid pathways leading to oxidative stress and mitochondrial damage.
Meihui Huang, Aoyang Long, Lingjia Hao, Zilin Shi, Mengqi Zhang   +4 more
wiley   +1 more source

The manicogenic properties of clozapine: a rare but serious potential adverse effect. [PDF]

J Psychiatry Neurosci
Cholette-Tétrault S, Bakhshi M, Traicu A, Joober R.   +3 more
europepmc   +1 more source

Subtype-specific dysregulation of biogenic amine-related genes and miRNAs in breast cancer: identification of DRD2, HRH2, and HRH4 as potential therapeutic targets in TNBC and HER2+ subtypes. [PDF]

Breast Cancer Res Treat
Sirek A, Sirek T, Nowakowski R, Borawski P, Ossowski P, Mitka-Krysiak K, Zmarzły N, Boroń K, Chalcarz M, Kuraszewska B, Szulik M, Boroń D, Grabarek BO.   +12 more
europepmc   +1 more source

Psilocybin as Transformative Fast‐Acting Antidepressant: Pharmacological Properties and Molecular Mechanisms

Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.
ABSTRACT In the 1950s–60s, serotonergic psychedelic drugs were studied as potential adjuvants to psychotherapy to treat addiction and alcoholism. However, starting in the 70s, preclinical and clinical studies on psychedelics stopped for decades because legislation controlled its recreational use, citing their hallucinogenic and psychotomimetic effects,
Makiath Adebo, Mathilda Bonnet, Ons Laouej, Celine Defaix, Josephine C. McGowan, Florence Butlen‐Ducuing, Denis J. David, Erwan Poupon, Laurent Tritschler, Alain M. Gardier   +9 more
wiley   +1 more source

EC₅₀ images reveal reproducible spatial variation in drug affinity across single- and repeat-dose occupancy studies. [PDF]

J Cereb Blood Flow Metab
Ibrahimy A, Kim SJ, Schmidt ME, Slifstein M, Mannaert E, Andrews RD, Matthews DC, Constantinescu CC, Searle GE, Gunn RN, Rabiner EA, Morris ED.   +11 more
europepmc   +1 more source

Alterations of appetite‐regulating hormones in risperidone treated children and adolescents—a post hoc analysis of the SPACe study

British Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 2090-2094, July 2025.
Weight gain and metabolic disruptions are common in children and adolescents treated with antipsychotics, but the underlying mechanisms are unclear, complicating prevention and treatment. This study examines the impact of risperidone on appetite‐regulating hormones (insulin, leptin and bioleptin) and their relationship to body weight changes over time.
Jiayi Liang, Brenda C. M. de Winter, Rebecca A. Hermans, Sanne M. Kloosterboer, Susanne Kuckuck, Izgi Bayraktar, Liesbeth F. C. van Rossum, Manon H. J. Hillegers, Sander A. A. van den Berg, Birgit C. P. Koch, Bram Dierckx   +10 more
wiley   +1 more source

Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D₂ Receptor. [PDF]

ACS Chem Neurosci
Lim HD, Bartuzi D, Keen AC, Rauffenbart C, Glenn J, Charlton SJ, Lovera S, Sands ZA, Ates A, Wood M, Canals M, Javitch JA, Carlsson J, Lane JR.   +13 more
europepmc   +1 more source

Does Propofol Interact with D2 Dopamine Receptors?

Survey of Anesthesiology, 1994
David G. Lambert, B. L. Appadu, Philip G. Strange   +2 more
openaire   +4 more sources