Results 21 to 30 of about 147,933 (225)

Pharmacological blockade of dopamine D1- or D2-receptor in the prefrontal cortex induces attentional impairment in the object-based attention test through different neuronal circuits in mice

Molecular Brain, 2021
Dopamine is a key neurotransmitter that regulates attention through dopamine D1 and D2-receptors in the prefrontal cortex (PFC). We previously developed an object-based attention test (OBAT) to evaluate attention in mice.
Bolati Wulaer, Kazuo Kunisawa, Moeka Tanabe, Aika Yanagawa, Kuniaki Saito, Akihiro Mouri, Toshitaka Nabeshima   +6 more
doaj   +1 more source

D2-Like Receptors Mediate Dopamine-Inhibited Insulin Secretion via Ion Channels in Rat Pancreatic β-Cells

Frontiers in Endocrinology, 2020
Dopamine (DA) has a vital role in the central nervous system and also modulates lipid and glucose metabolism. The present study aimed to investigate the effect of dopamine on insulin secretion and the underlying mechanisms in rat pancreatic β-cells. Data
Mengmeng Liu, Lele Ren, Xiangqin Zhong, Yaqin Ding, Tao Liu, Tao Liu, Zhihong Liu, Zhihong Liu, Xiaohua Yang, Lijuan Cui, Lijuan Cui, Lijun Yang, Yanying Fan, Yunfeng Liu, Yi Zhang, Yi Zhang   +15 more
doaj   +1 more source

Dysregulation of dopamine neurotransmission in the nucleus accumbens in immobilization-induced hypersensitivity

Frontiers in Pharmacology, 2022
Cast immobilization causes sensory hypersensitivity, which is also a symptom of neuropathic pain and chronic pain. However, the mechanisms underlying immobilization-induced hypersensitivity remain unclear.
Yuki Kishikawa, Yuki Kishikawa, Yukie Kawahara, Yoshinori N. Ohnishi, Naoki Sotogaku, Tomoko Koeda, Hiroshi Kawahara, Akinori Nishi   +7 more
doaj   +1 more source

Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats

Nature Neuroscience, 2010
We found that development of obesity was coupled with the emergence of a progressively worsening brain reward deficit. Similar changes in reward homeostasis induced by cocaine or heroin is considered a critical trigger in the transition from casual to ...
Paul M Johnson, P. Kenny
semanticscholar   +2 more sources

REDUCED EXPRESSION OF DOPAMINE D2-RECEPTORS ON PERIPHERAL BLOOD LYMPHOCYTES AS A MARKER FOR PROGRESSION OF SUBCORTICAL COGNITIVE IMPAIRMENTS

Zaporožskij Medicinskij Žurnal, 2013
Introduction. Peripheral blood lymphocytes (PBL) express neurotransmitter and neuropeptide receptors. The dopamine receptors in PBL may reflect the status of homologous brain receptors.
O. A. Levada , I. V. Dobrodub, A. V. Trailin   +2 more
doaj   +1 more source

A Concise Review of the Conflicting Roles of Dopamine-1 versus Dopamine-2 Receptors in Wound Healing

Molecules, 2017
Catecholamines play an important regulatory role in cutaneous wound healing. The exact role of dopamine in human epidermis has yet to be fully elucidated. Current published evidence describes its differential effects on two separate families of G protein
Alexandra R. Vaughn, Michael James Davis, Raja K. Sivamani, Roslyn Rivkah Isseroff   +3 more
doaj   +1 more source

Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum

Nature Communications, 2018
Dopamine D2 receptors (D2Rs) in the nucleus accumbens (NAc) regulate motivated behavior, but the underlying neurobiological mechanisms remain unresolved.
E. Gallo, Jozsef Meszaros, Jeremy Sherman, M. Chohan, E. Teboul, Claire S. Choi, H. Moore, J. Javitch, C. Kellendonk   +8 more
semanticscholar   +1 more source

Dopamine receptors antagonistically regulate behavioral choice between conflicting alternatives in C. elegans. [PDF]

PLoS ONE, 2014
Caenorhabditis elegans is a useful model to study the neuronal or molecular basis for behavioral choice, a specific form of decision-making. Although it has been implied that both D1-like and D2-like dopamine receptors may contribute to the control of ...
Daoyong Wang, Yonglin Yu, Yinxia Li, Yang Wang, Dayong Wang   +4 more
doaj   +1 more source

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors

Nature Communications, 2017
Atypical antipsychotic drugs (APDs) have been hypothesized to show reduced extrapyramidal side effects (EPS) due to their rapid dissociation from the dopamine D2 receptor.
D. Sykes, H. Moore, L. Stott, N. Holliday, J. Javitch, J. R. Lane, S. Charlton   +6 more
semanticscholar   +1 more source

Dopamine receptors in a songbird brain. [PDF]

, 2010
Dopamine is a key neuromodulatory transmitter in the brain. It acts through dopamine receptors to affect changes in neural activity, gene expression, and behavior.
Jarvis, ED, Kubikova, L, Wada, K
core   +2 more sources