Results 21 to 30 of about 150,460 (322)

Dopamine receptors antagonistically regulate behavioral choice between conflicting alternatives in C. elegans. [PDF]

PLoS ONE, 2014
Caenorhabditis elegans is a useful model to study the neuronal or molecular basis for behavioral choice, a specific form of decision-making. Although it has been implied that both D1-like and D2-like dopamine receptors may contribute to the control of ...
Daoyong Wang, Yonglin Yu, Yinxia Li, Yang Wang, Dayong Wang   +4 more
doaj   +1 more source

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors

Nature Communications, 2017
Atypical antipsychotic drugs (APDs) have been hypothesized to show reduced extrapyramidal side effects (EPS) due to their rapid dissociation from the dopamine D2 receptor.
D. Sykes, H. Moore, L. Stott, N. Holliday, J. Javitch, J. R. Lane, S. Charlton   +6 more
semanticscholar   +1 more source

Desensitized D2 autoreceptors are resistant to trafficking

Scientific Reports, 2017
Dendritic release of dopamine activates dopamine D2 autoreceptors, which are inhibitory G protein-coupled receptors (GPCRs), to decrease the excitability of dopamine neurons.
Brooks G. Robinson, James R. Bunzow, Jonathan B. Grimm, Luke D. Lavis, Joshua T. Dudman, Jennifer Brown, Kim A. Neve, John T. Williams   +7 more
doaj   +1 more source

Dopamine receptors in a songbird brain. [PDF]

, 2010
Dopamine is a key neuromodulatory transmitter in the brain. It acts through dopamine receptors to affect changes in neural activity, gene expression, and behavior.
Jarvis, ED, Kubikova, L, Wada, K
core   +2 more sources

Role of D1/D2 dopamin receptors antagonist perphenazine in morphine analgesia and tolerance in rats

Biomolecules & Biomedicine, 2013
While opioid receptors have been implicated in the development of tolerance, the subsequent mechanisms involved in these phenomena have not been completely understood.
Ercan Ozdemir, Ihsan Bagcivan, Sinan Gursoy   +2 more
doaj   +1 more source

Bioequivalence and Bioavailability of Receptors Dopamine (D2) and Serotonin in the Action of Antipsychotic Drugs

, 2017
Volume 9 • Issue 2 • 10000e76 J Bioequiv Availab, an open access journal ISSN: 0975-0851 First, who studied of occupancy degree the receptors D2 (D2Rprotein that, in humans, is encoded by the DRD2 gene) it was Farde and colleagues in 1980 who observed ...
Monica BUTNARIU
semanticscholar   +1 more source

Adrenergic agonists induce heterologous sensitization of adenylate cyclase in NS20Y-D2L cells [PDF]

, 2001
Adenylate cyclase activity in NS20Y cells expressing D2L dopamine receptors was examined following chronic treatment with norepinephrine and epinephrine.
Cumbay, Medhane G, Johnston, Christopher A, Vortherms, Timothy A, Watts, Val J   +3 more
core   +1 more source

Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance. [PDF]

PLoS ONE, 2010
Variation of the gene coding for D2 receptors (DRD2) has been associated with risk for schizophrenia and with working memory deficits. A functional intronic SNP (rs1076560) predicts relative expression of the two D2 receptors isoforms, D2S (mainly pre ...
Alessandro Bertolino, Paolo Taurisano, Nicola Marco Pisciotta, Giuseppe Blasi, Leonardo Fazio, Raffaella Romano, Barbara Gelao, Luciana Lo Bianco, Madia Lozupone, Annabella Di Giorgio, Grazia Caforio, Fabio Sambataro, Artor Niccoli-Asabella, Audrey Papp, Gianluca Ursini, Lorenzo Sinibaldi, Teresa Popolizio, Wolfgang Sadee, Giuseppe Rubini   +18 more
doaj   +1 more source

Antisera specific for D2 dopamine receptors [PDF]

Biochemical Journal, 1993
Antisera have been raised against two peptides from the sequence of D2 dopamine receptors: peptide 1 from the predicted second extracellular loop and peptide 2 from the predicted third intracellular loop. The antisera recognize specifically a 95 kDa band in Western blots of several bovine brain regions, which corresponds to the denatured D2 dopamine ...
Andrew J. Doherty, Philip G. Strange, Paul L. Chazot   +2 more
openaire   +3 more sources

Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response - a double-blind PET study in schizophrenia [PDF]

, 2007
Blockade of dopamine D2 receptors remains a common feature of all antipsychotics. It has been hypothesized that the extrastriatal (cortical, thalamic) dopamine D2 receptors may be more critical to antipsychotic response than the striatal dopamine D2 ...
AA Lammertsma, AL Nordstrom, Alan A Wilson, B Efron, C Studholme, D Joel, David Mamo, DV Sheehan, GE Alexander, GJ Mogenson, GM Simpson, H Hall, H Olsson, H Olsson, Irina Vitcu, J Arnt, J Arnt, JD Bremner, L de Haan, L Farde, L Farde, LS Pilowsky, M Talvik, Nathalie Ginovart, O Agid, Ofer Agid, P Voorn, R Kessler, RB Chronister, RC Roberts, RM Kessler, Robert B Zipursky, S Houle, S Kapur, S Kapur, S Kapur, S Kapur, S Kapur, S Leucht, S Nyberg, S Nyberg, Shitij Kapur, SN Haber, SR Kay, TR Barnes, V Bigliani, W Guy, X Xiberas, X Xiberas   +48 more
core   +1 more source