Results 21 to 30 of about 39,913 (215)

A Randomized, Sham‐Controlled Trial of Repetitive Transcranial Magnetic Stimulation Targeting M1 and S2 in Central Poststroke Pain: A Pilot Trial

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Central poststroke pain (CPSP), a neuropathic pain condition, is difficult to treat. Repetitive transcranial magnetic stimulation (rTMS) targeted to the primary motor cortex (M1) can alleviate the condition, but not all patients respond. We aimed to assess a promising alternative rTMS target, the secondary somatosensory cortex (S2),
Juhani Ojala, Jukka Vanhanen, Hanna Harno, Pantelis Lioumis, Selja Vaalto, Mari A. Kaunisto, Jukka Putaala, Marko Kangasniemi, Erika Kirveskari, Jyrki P. Mäkelä, Eija Kalso   +10 more
wiley   +1 more source

Two dopamine D2-like receptor genes from the silkworm (Bombyx mori) and their evolutionary history in metazoan

Scientific Reports, 2017
Dopamine is widely distributed in metazoans and is implicated in many physiological functions. Dopaminergic signaling is mediated through two classes of dopamine receptors, D1-like and D2-like.
Ping Chen, Peng Chen, Tian Li, Qi Shen, Deng-Feng Yan, Liang Zhang, Xi Chen, Yan Li, Wei Zhao   +8 more
doaj   +1 more source

Behavior‐ and Cell Type‐Specific Cortico‐Striatal Decoupling in a Parkinson's Disease‐Like Mouse Model

Advanced Science, EarlyView.
Utilizing dual‐site fiber photometry, this study examines cortico‐striatal coupling with cell type resolution, identifying behavior‐ and cell type‐specific cortico striatal decoupling and its dopamine‐dependent mechanism in a Parkinson's disease mouse model.
Xu‐Ran Yao, Yang Liu, Wei‐Tong Zheng, Mao‐Qing Huang, Kai‐Wen He   +4 more
wiley   +1 more source

A Novel Dopamine Receptor Signaling Unit in Brain: Heterooligomers of D1 And D2 Dopamine Receptors

The Scientific World Journal, 2007
The ability of G protein coupled receptors to heterooligomerize and create novel signaling complexes has demonstrated the tremendous potential of these receptors to access diverse signaling cascades, as well as to modulate the nature of the transduced ...
Susan R. George, Brian F. O'Dowd
doaj   +1 more source

Identification of dopamine receptors across the extant avian family tree and analysis with other clades uncovers a polyploid expansion among vertebrates

Frontiers in Neuroscience, 2015
Dopamine is an important central nervous system transmitter that functions through two classes of receptors (D1 and D2) to influence a diverse range of biological processes in vertebrates.
Asher eHaug-Baltzell, Asher eHaug-Baltzell, Erich David Jarvis, Erich David Jarvis, Fiona eMcCarthy, Fiona eMcCarthy, Eric eLyons, Eric eLyons, Eric eLyons   +8 more
doaj   +1 more source

Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons

Biomedicines, 2021
α-synuclein accumulation into dopaminergic neurons is a pathological hallmark of Parkinson’s disease. We previously demonstrated that fatty acid-binding protein 3 (FABP3) is critical for α-synuclein uptake and propagation to accumulate in dopaminergic ...
Ichiro Kawahata, Tomoki Sekimori, Haoyang Wang, Yanyan Wang, Toshikuni Sasaoka, Luc Bousset, Ronald Melki, Tomohiro Mizobata, Yasushi Kawata, Kohji Fukunaga   +9 more
doaj   +1 more source

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

Advanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges   +15 more
wiley   +1 more source

Noninvasive Glucose Detection with Biodegradable Electrodes from Rice Starch Functionalized with a Carbon Quantum Dot/Nickel Oxide Nanocomposite

Analysis &Sensing, EarlyView.
The graphical abstract shows an eco‐friendly approach to fabricating a biodegradable electrochemical sensor. Carbon quantum dot/nickel oxide (CQD/NiO) nanocomposites are synthesized using Aloe arborescens leaf extract, which served as a natural reducing and stabilizing agent.
Nokwanda Ngema, Ryal Atson, Orlette Mkhari, Mahabubur Rahman Chowdhury   +3 more
wiley   +1 more source

Selective blockade of spinal D2DR by levo-corydalmine attenuates morphine tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner

Experimental and Molecular Medicine, 2018
Pain medicine: why blocking dopamine receptors alleviates morphine tolerance By blocking dopamine receptors located in the spinal cord, a compound found in a traditional Chinese herbal medicine may help mitigate tolerance to morphine, a common problem ...
Wen-Ling Dai, Xin-Tong Liu, Yi-Ni Bao, Bing Yan, Nan Jiang, Bo-Yang Yu, Ji-Hua Liu   +6 more
doaj   +1 more source

Amphetamine Promotes Cortical Up State in Part Via Dopamine Receptors

Frontiers in Pharmacology, 2021
Cortical neurons oscillate between Up and Down states during slow wave sleep and general anesthesia. Recent studies show that Up/Down oscillations also occur during quiet wakefulness.
Guofang Shen, Wei-Xing Shi, Wei-Xing Shi
doaj   +1 more source