Results 31 to 40 of about 147,933 (225)

Desensitized D2 autoreceptors are resistant to trafficking

Scientific Reports, 2017
Dendritic release of dopamine activates dopamine D2 autoreceptors, which are inhibitory G protein-coupled receptors (GPCRs), to decrease the excitability of dopamine neurons.
Brooks G. Robinson, James R. Bunzow, Jonathan B. Grimm, Luke D. Lavis, Joshua T. Dudman, Jennifer Brown, Kim A. Neve, John T. Williams   +7 more
doaj   +1 more source

Adrenergic agonists induce heterologous sensitization of adenylate cyclase in NS20Y-D2L cells [PDF]

, 2001
Adenylate cyclase activity in NS20Y cells expressing D2L dopamine receptors was examined following chronic treatment with norepinephrine and epinephrine.
Cumbay, Medhane G, Johnston, Christopher A, Vortherms, Timothy A, Watts, Val J   +3 more
core   +1 more source

Bioequivalence and Bioavailability of Receptors Dopamine (D2) and Serotonin in the Action of Antipsychotic Drugs

, 2017
Volume 9 • Issue 2 • 10000e76 J Bioequiv Availab, an open access journal ISSN: 0975-0851 First, who studied of occupancy degree the receptors D2 (D2Rprotein that, in humans, is encoded by the DRD2 gene) it was Farde and colleagues in 1980 who observed ...
Monica BUTNARIU
semanticscholar   +1 more source

Role of D1/D2 dopamin receptors antagonist perphenazine in morphine analgesia and tolerance in rats

Biomolecules & Biomedicine, 2013
While opioid receptors have been implicated in the development of tolerance, the subsequent mechanisms involved in these phenomena have not been completely understood.
Ercan Ozdemir, Ihsan Bagcivan, Sinan Gursoy   +2 more
doaj   +1 more source

Antisera specific for D2 dopamine receptors [PDF]

Biochemical Journal, 1993
Antisera have been raised against two peptides from the sequence of D2 dopamine receptors: peptide 1 from the predicted second extracellular loop and peptide 2 from the predicted third intracellular loop. The antisera recognize specifically a 95 kDa band in Western blots of several bovine brain regions, which corresponds to the denatured D2 dopamine ...
Andrew J. Doherty, Philip G. Strange, Paul L. Chazot   +2 more
openaire   +3 more sources

Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response - a double-blind PET study in schizophrenia [PDF]

, 2007
Blockade of dopamine D2 receptors remains a common feature of all antipsychotics. It has been hypothesized that the extrastriatal (cortical, thalamic) dopamine D2 receptors may be more critical to antipsychotic response than the striatal dopamine D2 ...
AA Lammertsma, AL Nordstrom, Alan A Wilson, B Efron, C Studholme, D Joel, David Mamo, DV Sheehan, GE Alexander, GJ Mogenson, GM Simpson, H Hall, H Olsson, H Olsson, Irina Vitcu, J Arnt, J Arnt, JD Bremner, L de Haan, L Farde, L Farde, LS Pilowsky, M Talvik, Nathalie Ginovart, O Agid, Ofer Agid, P Voorn, R Kessler, RB Chronister, RC Roberts, RM Kessler, Robert B Zipursky, S Houle, S Kapur, S Kapur, S Kapur, S Kapur, S Kapur, S Leucht, S Nyberg, S Nyberg, Shitij Kapur, SN Haber, SR Kay, TR Barnes, V Bigliani, W Guy, X Xiberas, X Xiberas   +48 more
core   +1 more source

Involvement of D1 and D2 dopamine receptors in the antidepressant-like effects of selegiline in maternal separation model of mouse. [PDF]

, 2016
Mother-infant interactions are known to be associated with the psychological well-being of an individual in adulthood. It is well accepted that emotional stress in early life, such as maternal separation (MS), leads to alterations in the ...
Alijanpour, Sakineh., Amini-Khoei, Hossein., Amiri, Shayan., Haj-Mirzaian, Arya., Mehdizadeh, Mehdi., Mohammadi Asl, Ali., Olson, Carl O., Rahimi-Balaei, Maryam., Rastegar, Mojgan., Razmi, Ali., Zarrindast, MohammadReza.   +10 more
core   +1 more source

Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice

Scientific Reports, 2017
The loss of nigrostriatal dopamine neurons in Parkinson’s disease induces a reduction in the number of dendritic spines on medium spiny neurons (MSNs) of the striatum expressing D1 or D2 dopamine receptor.
Dominic Gagnon, S. Petryszyn, M. G. Sánchez, Cyril Bories, J. Beaulieu, Y. Koninck, A. Parent, M. Parent   +7 more
semanticscholar   +1 more source

Tonic inhibition of accumbal spiny neurons by extrasynaptic 4 GABAA receptors modulates the actions of psychostimulants [PDF]

, 2014
Within the nucleus accumbens (NAc), synaptic GABAA receptors (GABAARs) mediate phasic inhibition of medium spiny neurons (MSNs) and influence behavioral responses to cocaine.
Belelli, D, Dixon, C I, Herd, M B, King, S L, Lambert, J J, MacPherson, T, Maguire, E P, Stephens, D N, Swinny, J D   +8 more
core   +1 more source

Dopamine D2 receptors and the circadian clock reciprocally mediate antipsychotic drug-induced metabolic disturbances

npj Schizophrenia, 2017
Antipsychotic drugs are widely prescribed medications, used for numerous psychiatric illnesses. However, antipsychotic drugs cause serious metabolic side effects that can lead to substantial weight gain and increased risk for type 2 diabetes.
Zachary Freyberg, Michael J. McCarthy
doaj   +1 more source