Results 41 to 50 of about 147,933 (225)

Preferential binding to dopamine D3 over D2 receptors by cariprazine in patients with schizophrenia using PET with the D3/D2 receptor ligand [11C]-(+)-PHNO

Psychopharmacology, 2016
Second-generation antipsychotics occupy dopamine D2 receptors and act as antagonists or partial agonists at these receptors. While these drugs alleviate positive symptoms in patients with schizophrenia, they are less effective for treating cognitive ...
R. Girgis, M. Slifstein, D. D’Souza, Yih Lee, A. Periclou, P. Ghahramani, I. Laszlovszky, S. Durgam, N. Adham, N. Nabulsi, Yiyun Huang, R. Carson, B. Kiss, M. Kapás, A. Abi-Dargham, A. Rakhit   +15 more
semanticscholar   +1 more source

Probing the role of the cation–π interaction in the binding sites of GPCRs using unnatural amino acids [PDF]

, 2009
We describe a general application of the nonsense suppression methodology for unnatural amino acid incorporation to probe drug–receptor interactions in functional G protein-coupled receptors (GPCRs), evaluating the binding sites of both the M2 muscarinic
Ballesteros, Cho, D. A. Dougherty, Dougherty, Dougherty, Dougherty, Doupnik, Gallivan, H. A. Lester, Hibert, Hopkins, Huang, Huang, K. S. Bower, Klabunde, Kofuji, Krapivinsky, Lagerstrom, Lu, Lu, M. M. Torrice, Ma, Mark, Nemeth, Nowak, Palczewski, Rasmussen, Schwartz, Warne, Xiu, Zacharias, Zhong   +31 more
core   +3 more sources

A comprehensive review on the role of dopamine in the pathophysiology of tardive dyskinesia [PDF]

, 2023
Tardive dyskinesia (TD) is a neurological syndrome characterized by involuntary, repetitive, and unusual movements that primarily impact the orofacial region while also extending to other body parts, encompassing chorea, dystonia, tics, buccolingual ...
Kandasamy, Krishnaveni, Paramanandham, Abinaya, Ramalingam, Kameswaran, Suthi Kumari, Goshika Russel   +3 more
core   +2 more sources

In the Blink of an Eye: Relating Positive-Feedback Sensitivity to Striatal Dopamine D2-Like Receptors through Blink Rate

Journal of Neuroscience, 2014
For >30 years, positron emission tomography (PET) has proven to be a powerful approach for measuring aspects of dopaminergic transmission in the living human brain; this technique has revealed important relationships between dopamine D2-like receptors ...
S. Groman, A. James, E. Seu, S. Tran, Taylor A. Clark, S. N. Harpster, M. Crawford, Joanna Burtner, Karen Feiler, R. Roth, J. Elsworth, E. London, J. Jentsch   +12 more
semanticscholar   +1 more source

Molecular dynamics of dopamine at the D2 receptor. [PDF]

Proceedings of the National Academy of Sciences, 1991
A three-dimensional model of the dopamine D2 receptor, assumed to be a target of antipsychotic drug action, was constructed from its amino acid sequence. The model was based on structural similarities within the super-family of guanine nucleotide-binding regulatory (G) protein-coupled neuroreceptors and has seven alpha-helical transmembrane segments ...
Ingebright Sylte, Øyvind Edvardsen, Svein G. Dahl   +2 more
openaire   +3 more sources

In Vitro and In Vivo Characterization of PCC0104005, a Novel Modulator of Serotonin-Dopamine Activity, as an Atypical Antipsychotic Drug

Scientific Reports, 2018
PCC0104005 is a novel drug candidate for treating schizophrenia that displays high affinity for serotonin, dopamine, and noradrenaline receptors, including partial agonism at dopamine D2, D3, D4, serotonin 5-HT1A, and 5-HT2A receptors and antagonism at 5-
Yanan Xu, Xiaoyin Zhu, Hongbo Wang, Shanyue Sun, Xin Yue, Jingwei Tian   +5 more
doaj   +1 more source

Dopamine D1 and D2 receptor immunoreactivities in the arcuate-median eminence complex and their link to the tubero-infundibular dopamine neurons

European Journal of Histochemistry, 2014
Dopamine D1 and D2 receptor immunohistochemistry and Golgi techniques were used to study the structure of the adult rat arcuate-median eminence complex, and determine the distribution of the dopamine D1 and D2 receptor immunoreactivities therein ...
W. Romero-Fernandez, D.O. Borroto-Escuela, V. Vargas-Barroso, M. Narváez, M. Di Palma, L.F. Agnati, J. Larriva Sahd, K. Fuxe   +7 more
doaj   +1 more source

5-HT2A Receptors Modulate Dopamine D2-mediated Maternal Effects [PDF]

, 2020
Serotonin 5-HT2A receptors are expressed throughout the mesolimbic and mesocortical dopamine pathways, and manipulation of this receptor system has a profound impact on dopamine functions and dopamine-mediated behaviors.
Gao, Jun
core   +1 more source

Molecular modelling of interactions between antipsychotic drugs and receptors mediating antipsychotic effects and important side effects [PDF]

, 2021
Dopamine and serotonin are two neurotransmitters that exert their actions through mediation of dopaminergic and serotonergic receptors respectively. The receptors in focus in the current study, are the dopamine D2 and serotonin 5-HT2A receptors.
Issifou, Halimatu Sadia T.
core  

Two dopamine D2-like receptor genes from the silkworm (Bombyx mori) and their evolutionary history in metazoan

Scientific Reports, 2017
Dopamine is widely distributed in metazoans and is implicated in many physiological functions. Dopaminergic signaling is mediated through two classes of dopamine receptors, D1-like and D2-like.
Ping Chen, Peng Chen, Tian Li, Qi Shen, Deng-Feng Yan, Liang Zhang, Xi Chen, Yan Li, Wei Zhao   +8 more
doaj   +1 more source