Results 41 to 50 of about 151,968 (306)

Molecular dynamics of dopamine at the D2 receptor. [PDF]

Proceedings of the National Academy of Sciences, 1991
A three-dimensional model of the dopamine D2 receptor, assumed to be a target of antipsychotic drug action, was constructed from its amino acid sequence. The model was based on structural similarities within the super-family of guanine nucleotide-binding regulatory (G) protein-coupled neuroreceptors and has seven alpha-helical transmembrane segments ...
Ingebright Sylte, Øyvind Edvardsen, Svein G. Dahl   +2 more
openaire   +3 more sources

Probing the role of the cation–π interaction in the binding sites of GPCRs using unnatural amino acids [PDF]

, 2009
We describe a general application of the nonsense suppression methodology for unnatural amino acid incorporation to probe drug–receptor interactions in functional G protein-coupled receptors (GPCRs), evaluating the binding sites of both the M2 muscarinic
Ballesteros, Cho, D. A. Dougherty, Dougherty, Dougherty, Dougherty, Doupnik, Gallivan, H. A. Lester, Hibert, Hopkins, Huang, Huang, K. S. Bower, Klabunde, Kofuji, Krapivinsky, Lagerstrom, Lu, Lu, M. M. Torrice, Ma, Mark, Nemeth, Nowak, Palczewski, Rasmussen, Schwartz, Warne, Xiu, Zacharias, Zhong   +31 more
core   +3 more sources

In the Blink of an Eye: Relating Positive-Feedback Sensitivity to Striatal Dopamine D2-Like Receptors through Blink Rate

Journal of Neuroscience, 2014
For >30 years, positron emission tomography (PET) has proven to be a powerful approach for measuring aspects of dopaminergic transmission in the living human brain; this technique has revealed important relationships between dopamine D2-like receptors ...
S. Groman, A. James, E. Seu, S. Tran, Taylor A. Clark, S. N. Harpster, M. Crawford, Joanna Burtner, Karen Feiler, R. Roth, J. Elsworth, E. London, J. Jentsch   +12 more
semanticscholar   +1 more source

Pharmacological Evidence That Dopamine Inhibits the Cardioaccelerator Sympathetic Outflow via D2-Like Receptors in Pithed Rats

Journal of Pharmacological Sciences, 2013
It has been suggested that N,N-di-n-propyl-dopamine (dopamine analogue) decreased heart rate in rats through stimulation of dopamine receptors. Nevertheless, the role of prejunctional dopamine D1/2-like receptors or even α2-adrenoceptors to mediate ...
Oscar Alcántara-Vázquez, Ma. Trinidad Villamil-Hernández, Araceli Sánchez-López, David Centurión   +3 more
doaj   +1 more source

Dysfunctional Light-Evoked Regulation of cAMP in Photoreceptors and Abnormal Retinal Adaptation in Mice Lacking Dopamine D4 Receptors [PDF]

, 2002
Dopamine is a retinal neuromodulator that has been implicated in many aspects of retinal physiology. Photoreceptor cells express dopamine D4 receptors that regulate cAMP metabolism.
Grandy, David K., Haque, Rashidul, Harrison, Joseph M., Iuvone, P. Michael, Low, Malcolm J., Nir, Izhak, Rubinstein, Marcelo   +6 more
core   +1 more source

Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands

Nature Communications, 2020
The D2 dopamine receptor (DRD2) is one of the most well-established therapeutic targets for neuropsychiatric and endocrine disorders. Most clinically approved and investigational drugs that target this receptor are known to be subfamily-selective for all
L. Fan, L. Tan, Zhangcheng Chen, Jianzhong Qi, Fen Nie, Zhipu Luo, Jianjun Cheng, Sheng Wang   +7 more
semanticscholar   +1 more source

Could dopamine agonists aid in drug development for anorexia nervosa? [PDF]

, 2014
Anorexia nervosa is a severe psychiatric disorder most commonly starting during the teenage-years and associated with food refusal and low body weight. Typically there is a loss of menses, intense fear of gaining weight, and an often delusional quality ...
Frank, Guido KW
core   +2 more sources

Reduced Insulin Sensitivity Is Related to Less Endogenous Dopamine at D2/3 Receptors in the Ventral Striatum of Healthy Nonobese Humans

International Journal of Neuropsychopharmacology, 2015
Background: Food addiction is a debated topic in neuroscience. Evidence suggests diabetes is related to reduced basal dopamine levels in the nucleus accumbens, similar to persons with drug addiction.
F. Caravaggio, C. Borlido, M. Hahn, Zhe Feng, G. Fervaha*, P. Gerretsen, S. Nakajima, E. Plitman, J. Chung, Y. Iwata, Alan A. Wilson, G. Remington, A. Graff-Guerrero   +12 more
semanticscholar   +1 more source

Two dopamine D2-like receptor genes from the silkworm (Bombyx mori) and their evolutionary history in metazoan

Scientific Reports, 2017
Dopamine is widely distributed in metazoans and is implicated in many physiological functions. Dopaminergic signaling is mediated through two classes of dopamine receptors, D1-like and D2-like.
Ping Chen, Peng Chen, Tian Li, Qi Shen, Deng-Feng Yan, Liang Zhang, Xi Chen, Yan Li, Wei Zhao   +8 more
doaj   +1 more source

5-HT2A Receptors Modulate Dopamine D2-mediated Maternal Effects [PDF]

, 2020
Serotonin 5-HT2A receptors are expressed throughout the mesolimbic and mesocortical dopamine pathways, and manipulation of this receptor system has a profound impact on dopamine functions and dopamine-mediated behaviors.
Gao, Jun
core   +1 more source