Results 41 to 50 of about 39,913 (215)
Frontiers in Systems Neuroscience, 2011 Previous work has shown the functions associated with activation of dopamine presynaptic receptors in some substantia nigra pars reticulata (SNr) afferents: i) striatonigral terminals (direct pathway) posses presynaptic dopamine D1-class receptors whose ...
Jose De Jesus Aceves +6 more
doaj +1 more source
Brain Research Bulletin, 2022 Beta band (12–30 Hz) hypersynchrony within the basal ganglia-thalamocortical network has been suggested as a hallmark of Parkinson’s disease (PD) pathophysiology. Abnormal beta band oscillations are found in the pedunculopontine nucleus (PPN) and primary
Xuenan Wang +7 more
doaj +1 more source
Journal of Pediatric Gastroenterology and Nutrition, EarlyView.Abstract Objectives Pediatric intestinal pseudo‐obstruction (PIPO) is a severe bowel motility disorder characterized by impaired propulsion of gastrointestinal contents without mechanical obstruction. PIPO encompasses congenital and acquired disorders, including neuropathies, myopathies, and mesenchymopathies.
Sharon Wolfson +8 more
wiley +1 more source
Frontiers in Pharmacology, 2012 Dopamine D2 receptor antagonists modulate gene transcription in the striatum. However, the molecular mechanism underlying this effect remains elusive. Here we used the expression of Nur77, a transcription factor of the orphan nuclear receptor family, as ...
Jérôme eMaheux +7 more
doaj +1 more source
Movement Disorders Clinical Practice, EarlyView.ABSTRACT Background Classifying abnormal tongue movements is challenging due to their varied presentations and limited visibility compared to other body parts. Accurate identification of the phenomenology guides physical examination and can point to specific diagnoses.
Nathaniel Bendahan +4 more
wiley +1 more source
Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance
Molecular Brain, 2011 Dopamine is an important catecholamine neurotransmitter modulating many physiological functions, and is linked to psychopathology of many diseases such as schizophrenia and drug addiction.
Hasbi Ahmed +2 more
doaj +1 more source
Preservation of dendritic D2 receptor transmission in substantia nigra dopamine neurons with age
Scientific Reports, 2023 Substantia nigra pars compacta (SNc) dopamine neurons are required for voluntary movement and reward learning, and advanced age is associated with motor and cognitive decline.
Eva Troyano-Rodriguez +4 more
doaj +1 more source
Cocaine Sensitization: Modulation by Dopamine D2 Receptors [PDF]
Cerebral Cortex, 2002 Repeated administration of cocaine progressively increases drug-induced locomotor activity. This study examined the role of dopamine D(1)- and D(2)-like receptors in the medial prefrontal cortex (mPFC) in mediating these sensitized behaviors. For initiation experiments, animals received bilateral intra-mPFC injections of either saline, the D(1)-like ...
Chad E, Beyer, Jeffery D, Steketee
openaire +2 more sources
Morphological Changes in Direct Pathway Striatal Neurons in a Rat Model of Tardive Dyskinesia
Movement Disorders, EarlyView.Abstract Background Tardive dyskinesia (TD) and drug‐induced parkinsonism (DIP) arise from prolonged dopamine antagonist use. Although D2 receptor hypersensitivity in the indirect pathway is a proposed mechanism, the role of the direct pathway remains unclear.
Hiroki Hikichi +6 more
wiley +1 more source
Heterodimeric D1-D2 dopamine receptors: a review [PDF]
Biomeditsinskaya Khimiya, 2017 This review summarizes modern data on the structure and functions ofheteromersformed by D1 and D2 dopamine receptors focusing on their role in the mechanisms of drug dependence. This article discusses potential functional significance of heterodimeric D1-D2 dopamine receptorsdue to their localization in the brain as well as unique pharmacological ...
N L, Vekshina +3 more
openaire +2 more sources