Results 41 to 50 of about 150,460 (322)
Molecular dynamics of dopamine at the D2 receptor. [PDF]
Proceedings of the National Academy of Sciences, 1991 A three-dimensional model of the dopamine D2 receptor, assumed to be a target of antipsychotic drug action, was constructed from its amino acid sequence. The model was based on structural similarities within the super-family of guanine nucleotide-binding regulatory (G) protein-coupled neuroreceptors and has seven alpha-helical transmembrane segments ...
Ingebright Sylte +2 more
openaire +3 more sources
Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression. [PDF]
, 2018 gma σ1 and σ2 receptors are targets of cocaine. Despite sharing a similar name, the two receptors are structurally unrelated and their physiological role is unknown. Cocaine increases the level of dopamine, a key neurotransmitter in CNS motor control and
Aguinaga Andrés, David +6 more
core +1 more source
5-HT2A Receptors Modulate Dopamine D2-mediated Maternal Effects [PDF]
, 2020 Serotonin 5-HT2A receptors are expressed throughout the mesolimbic and mesocortical dopamine pathways, and manipulation of this receptor system has a profound impact on dopamine functions and dopamine-mediated behaviors.
Gao, Jun
core +1 more source
Dopamine elevates and lowers astroglial Ca(2+) through distinct pathways depending on local synaptic circuitry [PDF]
, 2016 Whilst astrocytes in culture invariably respond to dopamine with cytosolic Ca(2+) rises, the dopamine sensitivity of astroglia in situ and its physiological roles remain unknown. To minimize effects of experimental manipulations on astroglial physiology,
Bard, L +6 more
core +1 more source
Distinct regulation of dopamine D2S and D2L autoreceptor signaling by calcium [PDF]
, 2015 D2 autoreceptors regulate dopamine release throughout the brain. Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopamine neurons. Differential roles of these isoforms as autoreceptors are poorly understood.
Buck, David C. +6 more
core +3 more sources
Scientific Reports, 2017 Dopamine is widely distributed in metazoans and is implicated in many physiological functions. Dopaminergic signaling is mediated through two classes of dopamine receptors, D1-like and D2-like.
Ping Chen +8 more
doaj +1 more source
International Journal of Neuropsychopharmacology, 2015 Background: Food addiction is a debated topic in neuroscience. Evidence suggests diabetes is related to reduced basal dopamine levels in the nucleus accumbens, similar to persons with drug addiction.
F. Caravaggio +12 more
semanticscholar +1 more source
Mechanisms underlying the endogenous dopaminergic inhibition of spinal locomotor circuit function in Xenopus tadpoles [PDF]
, 2016 This work was supported by the Biotechnology and Biological Science Research Council (BBSRC) [grant number BB/J01446X/1].Dopamine plays important roles in the development and modulation of motor control circuits.
Picton, Laurence David +1 more
core +1 more source
Fluorescent ligands for dopamine D2/D3 receptors [PDF]
Scientific Reports, 2020 AbstractFluorescent ligands are versatile tools for the study of G protein-coupled receptors. Depending on the fluorophore, they can be used for a range of different applications, including fluorescence microscopy and bioluminescence or fluorescence resonance energy transfer (BRET or FRET) assays.
Allikalt, Anni +7 more
openaire +4 more sources
Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission
Scientific Reports, 2016 In addition to dopamine neuron firing, cholinergic interneurons (ChIs) regulate dopamine release in the striatum via presynaptic nicotinic receptors (nAChRs) on dopamine axon terminals.
Aphroditi A. Mamaligas +2 more
semanticscholar +1 more source