Results 61 to 70 of about 751,516 (267)

Dopamine D2 antagonist-induced striatal Nur77 expression requires activation of mGlu5 receptors by cortical afferents

Frontiers in Pharmacology, 2012
Dopamine D2 receptor antagonists modulate gene transcription in the striatum. However, the molecular mechanism underlying this effect remains elusive. Here we used the expression of Nur77, a transcription factor of the orphan nuclear receptor family, as ...
Jérôme eMaheux, Michel eSt-Hilaire, David eVoyer, Emanuele eTirotta, Emiliana eBorrelli, Claude eRouillard, Pierre-Paul eRompré, Daniel eLévesque   +7 more
doaj   +1 more source

Advances in Unraveling the Structure and Sodium‐Ion Storage Behaviors of Hard Carbons: From Basic to Extended Characterization Techniques

Carbon Energy, EarlyView.
This review is devoted to introducing the structures and sodium storage mechanisms of hard carbon materials and analyzing the correlated advanced characterization techniques. The advanced characterization techniques are categorized based on the classification of signal sources.
Jiechang Gao, Dongqi Zhang, Guanglei Qiu, Ye Han, Haijun Zhang, Yajie Liu, Zhixin Tai   +6 more
wiley   +1 more source

Stevia-Derived Diterpenoids as Potential Dopamine D2 Receptor Antagonists for Insomnia and Schizophrenia Therapy: An In Silico Study

Iraqi Journal of Pharmaceutical Sciences
Insomnia is the second most common mental disorder and causes several health risks. Stevia water extract is a popular natural sweetener and promotes health benefits including antioxidant, anti-inflammatory, antimicrobial, antidiabetic, anticancer, anti ...
Sentot Joko Raharjo, Dewi Ratih Tirto Sari, Ernanin Dyah Wijayanti, Yanty Maryanty   +3 more
doaj   +3 more sources

Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance

Molecular Brain, 2011
Dopamine is an important catecholamine neurotransmitter modulating many physiological functions, and is linked to psychopathology of many diseases such as schizophrenia and drug addiction.
Hasbi Ahmed, O'Dowd Brian F, George Susan R   +2 more
doaj   +1 more source

Preservation of dendritic D2 receptor transmission in substantia nigra dopamine neurons with age

Scientific Reports, 2023
Substantia nigra pars compacta (SNc) dopamine neurons are required for voluntary movement and reward learning, and advanced age is associated with motor and cognitive decline.
Eva Troyano-Rodriguez, Harris E. Blankenship, Kylie Handa, Sarah Y. Branch, Michael J. Beckstead   +4 more
doaj   +1 more source

Inclusion Complexations of Levamisole and Cocaine With Molecular Baskets. Fluorescence Displacement Assay for Detection of Cocaine and Its Adulterant Levamisole in Aqueous Media

Chemistry – A European Journal, EarlyView.
Levamisole is a common adulterant found in street‐distributed cocaine. Molecular baskets have been shown to form stable inclusion complexes with both substances. While levamisole inserts its benzene into the basket's cavity, cocaine utilizes its bicyclic ring for encapsulation.
Christopher T. Mortensen, Carson E. Ward, Nitesh Kumar, Logan Willemann, Ryan Lutz, Kailey Hughes, Zheng Zheng, Jovica D. Badjić   +7 more
wiley   +1 more source

In vivo PET quantification of the dopamine transporter in rat brain with [¹⁸F]LBT-999. [PDF]

, 2013
INTRODUCTION: We examined whether [(18)F]LBT-999 ((E)-N-(4-fluorobut-2-enyl)2β-carbomethoxy-3β-(4'-tolyl)nortropane) is an efficient positron emission tomography (PET) tracer for the quantification of the dopamine transporter (DAT) in the healthy rat ...
Sérrière, Sophie, Tauber, Clovis, Chalon, Sylvie, Vercouillie, Johnny, Garreau, Lucette, Guilloteau, Denis, Galineau, Laurant, Deloye, Jean-Bernard   +7 more
core   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

D2-like dopamine receptors mediate the response to amphetamine in a mouse model of ADHD

Neurobiology of Disease, 2007
The mechanisms underlying the effects of psychostimulants in attention deficit hyperactivity disorder (ADHD) are not well understood, but indirect evidence implicates D2 dopamine receptors. Here we dissect the components of dopaminergic neurotransmission
Xueliang Fan, Ellen J. Hess
doaj   +1 more source

Dopamine responsiveness is regulated by targeted sorting of D2 receptors

, 2005
Aberrant dopaminergic signaling is a critical determinant in multiple psychiatric disorders, and in many disease states, dopamine receptor number is altered.
Armstrong, R, Enquist, Johan, Kharazia, Viktor, Armstrong, Randall, Whistler, Jennifer, Bartlett, S E, Waldhoer, Maria, Hopf, F W, Kharazia, V, Mailliard, W S, Lee, J H, Hopf, F. Woodward, Mailliard, William, Gladher, Fredrik, Waldhoer, M, Lee, Josephine, Bonci, Antonello, Whistler, J L, Bartlett, Selena, Lund University., Gladher, F, Bonci, A, Enquist, Johan,   +22 more
core   +1 more source