Results 71 to 80 of about 80,664 (276)
The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components [PDF]
, 2014 G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner.
Agnati, Luigi F +12 more
core +4 more sources
Cocaine Sensitization: Modulation by Dopamine D2 Receptors [PDF]
Cerebral Cortex, 2002 Repeated administration of cocaine progressively increases drug-induced locomotor activity. This study examined the role of dopamine D(1)- and D(2)-like receptors in the medial prefrontal cortex (mPFC) in mediating these sensitized behaviors. For initiation experiments, animals received bilateral intra-mPFC injections of either saline, the D(1)-like ...
Chad E, Beyer, Jeffery D, Steketee
openaire +2 more sources
Absence seizures: Update on signaling mechanisms and networks
Epilepsia Open, EarlyView.Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley +1 more source
Heterodimeric D1-D2 dopamine receptors: a review [PDF]
Biomeditsinskaya Khimiya, 2017 This review summarizes modern data on the structure and functions ofheteromersformed by D1 and D2 dopamine receptors focusing on their role in the mechanisms of drug dependence. This article discusses potential functional significance of heterodimeric D1-D2 dopamine receptorsdue to their localization in the brain as well as unique pharmacological ...
N L, Vekshina +3 more
openaire +2 more sources
iNew Medicine, EarlyView.In the freezing of gait in Parkinson's disease, white matter shows decreased local activity but increased functional connectivity. These distinct dysfunctions are uniquely associated with specific neurotransmitter systems (GABA, dopamine, etc.), mapping a new neurochemical basis for this debilitating symptom. ABSTRACT Freezing of gait (FOG) is a severe
Pingping Liu +10 more
wiley +1 more source
Spatial Frequency Selectivity Is Impaired in Dopamine D2 Receptor Knockout Mice
Frontiers in Integrative Neuroscience, 2018 Dopamine is a neurotransmitter implicated in several brain functions, including vision. In the present study, we investigated the impacts of the lack of D2 dopamine receptors on the structure and function of the primary visual cortex (V1) of D2-KO mice ...
Bruno Oliveira Ferreira Souza +4 more
doaj +1 more source
Movement Disorders Clinical Practice, EarlyView.ABSTRACT Background Classifying abnormal tongue movements is challenging due to their varied presentations and limited visibility compared to other body parts. Accurate identification of the phenomenology guides physical examination and can point to specific diagnoses.
Nathaniel Bendahan +4 more
wiley +1 more source
D2-like dopamine receptors mediate the response to amphetamine in a mouse model of ADHD
Neurobiology of Disease, 2007 The mechanisms underlying the effects of psychostimulants in attention deficit hyperactivity disorder (ADHD) are not well understood, but indirect evidence implicates D2 dopamine receptors. Here we dissect the components of dopaminergic neurotransmission
Xueliang Fan, Ellen J. Hess
doaj +1 more source
Dysbindin promotes the post-endocytic sorting of G protein-coupled receptors to lysosomes. [PDF]
PLoS ONE, 2010 Dysbindin, a cytoplasmic protein long known to function in the biogenesis of specialized lysosome-related organelles (LROs), has been reported to reduce surface expression of D2 dopamine receptors in neurons.
Aaron Marley, Mark von Zastrow
doaj +1 more source
Hypotensive Episodes Precede Cognitive Fluctuations in Parkinson's Disease Dementia
Movement Disorders Clinical Practice, EarlyView.Abstract Background Cognitive fluctuations (CFs) are a disabling feature in Parkinson's disease dementia (PDD) and contribute to caregiver burden. The relationship between CFs and neurogenic orthostatic hypotension (nOH), a common autonomic complication in PDD, has not been adequately examined.
Jorge Patino +6 more
wiley +1 more source